Insulin growth factor (IGF) 1, IGF-binding proteins and ovarian cancer risk: A systematic review and meta-analysis

Gianuzzi, Ximena; Palma-Ardiles, Gabriela; Hernández-Fernández, Wendy; Pasupuleti, Vinay; Hernández, Adrian V.; Pérez‐López, Faustino R.

doi:10.1016/j.maturitas.2016.08.012

Cited by 28 publications

(20 citation statements)

References 40 publications

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“…The small sample size, and accordingly few cancer-related deaths, limits the ability to perform further adjustments than for age, making it difficult to further assess the significance of the strong correlation between IGFBP-1 and IGF-1 in this study. Signorello et al 27 demonstrated a positive association between IGFBP-1 and prostate cancer and Gianuzzi et al 28 reported on high IGFBP-1 levels in patients with ovarian cancer. The levels of IGFBP-1 may vary depending on the type of tumours.…”

Section: Discussionmentioning

confidence: 99%

Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

Ritsinger

Brismar

Mellbin

et al. 2018

Diabetes and Vascular Disease Research

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Section: Discussionmentioning

confidence: 99%

Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

Ritsinger

Brismar

Mellbin

et al. 2018

Diabetes and Vascular Disease Research

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“…The IGF1/PI3K/NFκB/Erk pathway was found to be upregulated in ovarian specimens of patients demonstrating relative resistance compared with those demonstrating sensitivity (33). Furthermore, high circulating IGF-1 levels have been correlated with decreased OC risk, and overall and progression-free survival were significantly prolonged in patients with higher serum IGF1 levels (34)(35)(36). However, the underlying reason for the abnormality of IGF1 in OC patients remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Upregulation of IGF1 by tumor-associated macrophages promotes the proliferation and migration of epithelial ovarian cancer cells

Liu

Wang

et al. 2017

Oncol Rep

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Abstract. Ovarian cancer (OC), of which epithelial ovarian cancer (EOC) is the most common, is the deadliest gynecological tumor because of the difficulties in detection at early stages, and metastasis and chemoresistance at advanced stages. Tumor-associated macrophages (TAMs) differentiate through alternative pathways and play important roles in tumor growth and metastasis. However, the underlying mechanism remains unclear. Here, we established a mouse TAM model using bone marrow monocytes and conditioned medium (CM) of TAMs to culture ID8 mouse EOC cells. The results showed that TAM CM accelerated the proliferation and migration of ID8 cells. In a previous study, gene chip analysis showed that human TAMs expressed significantly higher levels of insulinlike growth factor-1 (IGF1) than undifferentiated M0 myeloid cells. In the present study, we observed that the IGF1 level was higher in human EOC specimens than that in benign ovarian tumor specimens, and further analysis showed that a higher level of IGF1 was related to more advanced clinical stage and liver metastasis. Therefore, we hypothesized that TAMs may accelerate the proliferation and migration of EOC cells by upregulating IGF1. As expected, increased IGF1 expression at both the mRNA and protein levels was observed in ID8 cells cultured with TAM CM, whereas blockade of the IGF1 pathway in ID8 cells with an IGF1 neutralizing antibody effectively reversed the promotion of proliferation and migration. Finally, we inhibited the phosphorylation of insulin-like growth factor-1 receptor (IGF1R) and its downstream molecules Akt and Erk with the IGF1R inhibitor linsitinib, and observed that the treatment effectively suppressed the proliferation and migration of ID8 cells exposed to TAM CM. Thus, we demonstrated that TAMs may promote the growth and metastasis of EOC via the activation of the IGF1 pathway; thus, targeting the IGF1 pathway may be promising for EOC therapy.

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“…Critically, the availability of free and bioactive IGF-1 is modified, primarily, by concentrations of IGF-1 binding proteins (IGFBP) [14]. Evidence of associations between IGFBP and IGF-1 levels and cancer phenotypes at the population level have been reported in the literature [21–25]. The links between dietary carbohydrates and cancer risk are hypothesized to involve mechanisms that directly implicate players in insulin-mediated pathways across various tissue types as well as through modulation of IGF-1 bioactivity [26–28].…”

Section: Mechanistic Frameworkmentioning

confidence: 99%

Carbohydrate Nutrition and the Risk of Cancer

et al. 2019

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Purpose of Review This review summarizes a selection of epidemiologic research assessing the associations between carbohydrate intake and cancer incidence and survival. Evidence for plausible biological mechanisms is also considered. Recent Findings The mechanistic paradigm explaining the relationship between carbohydrates and cancer risk has been contested by numerous observational studies. Summary Carbohydrates have conventionally been ascribed a deleterious role in the field of cancer research due to previous preclinical findings. A breadth of studies suggests that complex carbohydrate intake is inversely associated with risk of a number of cancer types. Data from studies assessing simple carbohydrates and cancer risk are mixed. Furthermore, recommendations for subsequent studies are framed.

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Insulin growth factor (IGF) 1, IGF-binding proteins and ovarian cancer risk: A systematic review and meta-analysis

Cited by 28 publications

References 40 publications

Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

Elevated levels of insulin-like growth factor-binding protein 1 predict outcome after acute myocardial infarction: A long-term follow-up of the glucose tolerance in patients with acute myocardial infarction (GAMI) cohort

Upregulation of IGF1 by tumor-associated macrophages promotes the proliferation and migration of epithelial ovarian cancer cells

Carbohydrate Nutrition and the Risk of Cancer

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