2012
DOI: 10.1682/jrrd.2011.04.0076
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Insulin growth factors may explain relationship between spasticity and skeletal muscle size in men with spinal cord injury

Abstract: Abstract-The major objectives of this cross-sectional study were to (1) measure insulin-like growth factor-1 (IGF-1) in individuals with complete spinal cord injury (SCI) and spasticity and (2) determine the relationships between IGF-1 and cross-sectional areas (CSAs) of thigh skeletal muscle groups. Eight individuals with motor complete SCI underwent magnetic resonance imaging to measure the CSA of the whole thigh, knee extensor, and knee flexor skeletal muscle groups and dual-emission X-ray absorptiometry to… Show more

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Cited by 24 publications
(18 citation statements)
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“…49 However, IGF-1 was strongly correlated to muscle size in men with complete SCI. 50 In the present study, lower adiponectin concentration in overweight (9.9 ± 3.1 μg/ml) compared to normal weight premenopausal women (14.4 ± 4.7 μg/ml), with adiponectin inversely related to parameters including BMI, body weight, and truncal fat. In a cross-sectional study in men with SCI, 58 adiponectin ranged from 2.9 to 37.2 μg/ml and was inversely associated with waist circumference and trunk fat, although in another study, 59 it was similar between able-bodied individuals and those with SCI, with this discrepancy being explained by similar body weight and BMI between subjects as well as different assays performed (ELISA versus RIA) across studies.…”
Section: Discussionsupporting
confidence: 46%
“…49 However, IGF-1 was strongly correlated to muscle size in men with complete SCI. 50 In the present study, lower adiponectin concentration in overweight (9.9 ± 3.1 μg/ml) compared to normal weight premenopausal women (14.4 ± 4.7 μg/ml), with adiponectin inversely related to parameters including BMI, body weight, and truncal fat. In a cross-sectional study in men with SCI, 58 adiponectin ranged from 2.9 to 37.2 μg/ml and was inversely associated with waist circumference and trunk fat, although in another study, 59 it was similar between able-bodied individuals and those with SCI, with this discrepancy being explained by similar body weight and BMI between subjects as well as different assays performed (ELISA versus RIA) across studies.…”
Section: Discussionsupporting
confidence: 46%
“…46 The positive relationship between spasticity and muscle size as well as lean mass has recently been explained by the effect of spasticity on the circulating plasma IGF-1. 47 Those with MAS greater than 2 have 44% higher plasma IGF-1 than those with lower MAS. 47 In summary, the above findings suggest that body composition adaptations after SCI occur at cellular, muscular, regional, and whole-body levels.…”
Section: % Of Individuals With Sci Had a Testosterone Level Gorgey mentioning
confidence: 93%
“…[24][25][26] Spasticity may provoke muscular IGF-1 that compensates for the reduced growth hormone-IGF-1 axis after SCI. 7 Although MAS is the most commonly used tool for measuring spasticity in clinical practice and research, the reliability and validity of this scale remain unclear. 27,28 Moreover, the degree of spasticity can vary according to the patient's physical and emotional conditions, even within a single day.…”
Section: Discussionmentioning
confidence: 99%
“…In addition, mechanisms through which severe spasticity ameliorates the derangement of body compositions and glucose homeostasis could be investigated. For example, differences in the expression of glucose transport protein, GLUT4 proteins, 30 IGF-1 concentration 7,29 and muscle fiber type composition 22,23 have been suggested as related mechanisms.…”
Section: Discussionmentioning
confidence: 99%
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