Insulin-induced Lipoatrophy in a Patient on Insulin Analogue Therapy: a Case Report

Yanachkova, Vesselina; Staynova, Radiana

doi:10.3897/folmed.62.e50166

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The main reasons for patient refusal were inconvenient of insulin treatment (51.6%) and fear of injection (48.2%) (9). Due to the long course of disease, patients receiving insulin injections generally ignore the injection site rotation strategy and often reuse needles, which leads to subcutaneous fat hypertrophy (10)(11)(12)(13)(14)(15). This, in turn, affects glycemic control, resulting in unexplained hypoglycemia and a significant increase in blood glucose change levels (11,16,17), which leads to an increase in insulin costs (18).…”

Section: Discussionmentioning

confidence: 99%

The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals

Pan

Zhang

et al. 2022

Front. Endocrinol.

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The absorption of needle-free fast-acting insulin injected into different body parts of healthy male subjects was studied in an attempt to provide clinical guidance for diabetic patients who take needle-free insulin injections in terms of providing reference in the clinical guidance regarding the correct use of needle-free insulin injections among diabetic patients. This randomized, open-label, cross-over trial was conducted on eight healthy adult male volunteers, in which the skin thickness at three injection sites (abdomen, upper arm, and thigh), the time to peak, peak rate, and area under the glucose infusion rate (GIR) curve of plasma insulin were measured through the hyperinsulin-normal glucose clamp test after the injection of insulin aspart with a needle-free syringe at three different sites to analyze the correlation between insulin absorption index at different injection sites and skin thickness. The values of the skin thickness of the abdomen, upper arm, and thigh measured by ultrasonic wave were 2.45 ± 0.34 mm, 2.18 ± 0.50 mm, and 1.93 ± 0.55 mm, respectively. There was a significant difference in the skin thickness of the abdomen and thigh (P = 0.014). The hyperinsulin-normal glucose clamp model was successfully established for each subject. Approximately 0–2 h after injection of insulin aspart with needle-free syringes, the area under the GIR-time curve of the abdomen, upper arm, and thigh was 29,400.75 ± 2,645.00 ml, 30,230.50 ± 4,937.87 ml, and 30,179.63 ± 6,188.57 ml, respectively. There was no significant difference in the area under the GIR curve between any two injection sites (P >0.05). The time to peak of GIR at different injection sites was 38.68 ± 13.57 min in the abdomen, 40.86 ± 12.70 min in the upper arm, and 37.03 ± 13.29 min in the thigh, respectively, in which no significant difference was found between each of them (P >0.05). The GIR curve after injection at the three different sites was consistent with each other. There was no significant difference in insulin absorption after the injection of insulin aspartate into the abdomen, upper arm, and thigh with a needleless syringe in healthy male adult volunteers, and there was no correlation between skin thickness at the injection site and insulin absorption. Injection sites did not affect the absorption of insulin in needle-free injections.

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Section: Discussionmentioning

confidence: 99%

The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals

Pan

Zhang

et al. 2022

Front. Endocrinol.

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“…However, at present, nurses have insufficient insulin injection knowledge in clinical practice and are not skilled in insulin injection (Grassi et al, 2014 ; Misnikova et al, 2017 ; Song et al, 2018 ). Inappropriate injection may lead to subcutaneous fat hyperplasia (Conwell et al, 2008 ; Pickup et al, 2014 ), fat atrophy (Breznik et al, 2013 ; Holstein et al, 2010 ; Yanachkova & Staynova, 2020 ) and pain (Hanberger et al, 2021 ), reducing insulin absorption and affecting blood glucose control. Wu et al ( 2021 ) have conducted a cross‐sectional study on the insulin injection knowledge, attitude and behaviour of nurses in different medical institutions in various provinces and cities in China.…”

Section: Introductionmentioning

confidence: 99%

Insulin injection knowledge, attitude and behaviour of nurses: A cross‐sectional study in Guangdong Province

et al. 2023

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Aim To understand the insulin injection knowledge, attitude and behaviour of nurses and their influencing factors in Guangdong Province. Design Cross‐sectional study. Methods A total of 19,853 nurses from 82 hospitals in 15 cities in Guangdong, China, participated in this study. The scores of the nurses' insulin injection knowledge, attitude and behaviour were determined through a questionnaire, and multivariate regression analysis was used to evaluate the influencing factors of insulin injection in different dimensions. STROBE. Results Among all nurses involved in this study, 22.3% of nurses had good knowledge, 75.9% of nurses had good attitude and 92.7% of nurses had good behaviour. Pearson's correlation analysis showed that knowledge, attitude scores and behaviour scores were significantly correlated. The influencing factors of knowledge, attitude and behaviour included gender, age, education, nurse level, work experience, type of ward, diabetes nursing certification, position held and most recent insulin administration.

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Type 1 Diabetes Mellitus and Lipohypertrophy - Impact of the Intervention on Glycemic Control via Patient’s Examination and Retraining on Change of Infusion Set

et al. 2023

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Insulin-induced Lipoatrophy in a Patient on Insulin Analogue Therapy: a Case Report

Cited by 4 publications

References 9 publications

The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals

The Absorption of Needle-Free Insulin Aspart Through Jet Injector in Different Body Parts of Healthy Individuals

Insulin injection knowledge, attitude and behaviour of nurses: A cross‐sectional study in Guangdong Province

Type 1 Diabetes Mellitus and Lipohypertrophy - Impact of the Intervention on Glycemic Control via Patient’s Examination and Retraining on Change of Infusion Set

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