Insulin induces phosphorylation of the AMPA receptor subunit GluR1, reversed by ZIP, and over‐expression of Protein Kinase M zeta, reversed by amyloid beta

Adzovic, Linda; Domenici, Luciano

doi:10.1111/jnc.12947

Cited by 37 publications

(27 citation statements)

References 49 publications

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“…It is thought to be more powerful in destructing the physiology of learning and memory. Thus, it is thought that soluble Aβ oligomers could be the "initiation factor" of AD in the early stages of AD pathology [3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Cerebrospinal Fluid With The Intake of Xixin Decoction on Hippocampal Neuron Apoptosis Induced by Aβ1-42

Yong-chang¹,

Meng²,

Wang³

et al. 2017

J Aging Sci

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Objective: To study the protective effects of cerebrospinal fluid with the intake of Xixin Decoction (CSF) on Aβ 1-42-induced apoptosis in rat hippocampal neurons. Methods:Hippocampal neurons were extracted from Wistar newborn rats and cultured in vitro. Cultured neurons were divided into the following groups: the normal control group, the Aβ model group, the low concentration treatment group, the medium concentration treatment group, and the high concentration treatment group. We analyzed cell viability using an MTT assay. Cell apoptosis was observed using transmission electron microscopy, and the rate of cell apoptosis was measured with flow cytometry using Annexin V/PI double staining kit. The gene expression and protein expression levels of Caspase-9, Bcl-2, and Bax in cells were measured using Real-time PCR, Western blot, and immunofluorescence techniques.Results: cerebrospinal fluid with the intake of Xixin Decoction was found to improve the survival rate of cells, improve cell morphology during apoptosis, and reduce the number of apoptotic cells. Compared with the control group, the expression levels of Caspse-9 and Bax were increased in the model group, while the Bcl-2 expression level was decreased. In addition, the expression levels of Caspase-9 and Bax were found to be reduced in each treatment group, compared with the model group. It was also quite evident that Bcl-2 expression levels were increased (P<0.05 or P<0.01). Conclusion:cerebrospinal fluid with the intake of Xixin Decoction exhibits a significant protective effect on cells against Aβ 1-42 -induced apoptosis. Importantly, we demonstrate a dose-effect relationship, with the effects of cerebrospinal fluid with the intake of Xixin Decoction at a density of 20% showing the most significant results.

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Section: Discussionmentioning

confidence: 99%

Protective Effects of Cerebrospinal Fluid With The Intake of Xixin Decoction on Hippocampal Neuron Apoptosis Induced by Aβ1-42

Yong-chang¹,

Meng²,

Wang³

et al. 2017

J Aging Sci

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“…The mechanisms are complex. It is found that insulin can activate α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid (AMPA) receptors and leads to increased hippocampal long-term potentiation (LTP; Adzovic and Domenici, 2014). Another mechanism involving insulin modulated cognition is via inflammation pathway.…”

Section: Gut Dysbacteriosis Contributes To DCImentioning

confidence: 99%

The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment

Zhou

Zhu

2017

Front. Aging Neurosci.

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Progressive cognitive dysfunction is a central characteristic of diabetic encephalopathy (DE). With an aging population, the incidence of DE is rising and it has become a major threat that seriously affects public health. Studies within this decade have indicated the important role of risk factors such as oxidative stress and inflammation on the development of cognitive impairment. With the recognition of the two-way communication between gut and brain, recent investigation suggests that “microbiota-gut-brain axis” also plays a pivotal role in modulating both cognition function and endocrine stability. This review aims to systemically elucidate the underlying impact of diabetes on cognitive impairment.

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“…). AMPARs also appear to influence β‐amyloid‐related processing: recently a new intracellular insulin signalling pathway was described involving glutamate R1 subunit‐containing AMPARs which influenced the production and accumulation of β‐amyloid (Adzovic and Domenici ). AMPAR up‐regulation has been proposed to be a link to locomotor sensitization and enhanced drug seeking behaviour (Boudreau et al .…”

Section: Amino Acid‐mediated Transmission Signalling and Pathobiologymentioning

confidence: 99%

Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future

Beart

2016

Journal of Neurochemistry

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This 'Past to Future' Review as part of the 60th anniversary year of the Journal of Neurochemistry focuses on synaptic transmission and associated signalling, and seeks to identify seminal progress in neurochemistry over the last 10 years which has advanced our understanding of neuronal communication in brain. The approach adopted analyses neurotransmitters on a case by case basis (i.e. amino acids, monoamines, acetylcholine, neuropeptides, ATP/purines and gasotransmitters) to highlight novel findings that have changed the way we view each type of transmitter, to explore commonalities and interactions, and to note how new insights have changed the way we view the biology of degenerative, psychiatric and behavioural conditions. Across all transmitter systems there was remarkable growth in the identification of targets likely to provide therapeutic benefit and which undoubtedly was driven by the elucidation of circuit function and new vistas of synaptic signalling. There has been an increasing trend to relate signalling to disease, notably for Alzheimer's and Parkinson's disease and related conditions, and which has occurred for each transmitter family. Forebrain circuitry and tonic excitatory control have been the centre of great attention yielding novel findings that will impact upon cognitive, emotional and addictive behaviours. Other impressive insights focus on gasotransmitters integrating activity as volume transmitters. Exciting developments in how serotonin, cholinergic, l-glutamate, galanin and adenosine receptors and their associated signalling can be beneficially targeted should underpin the development of new therapies. Clearly integrated, multifaceted neurochemistry has changed the way we view synaptic signalling and its relevance to pathobiology. Highlighted are important advances in synaptic signalling over the last decade in the Journal of Neurochemistry. Across all transmitter systems elucidation of circuit function, and notably molecular insights, have underpinned remarkable growth in the identification of targets likely to provide therapeutic benefit in neuropathologies. Another commonality was wide interest in forebrain circuitry and its tonic excitatory control. Increasingly observations relate to signalling in disease and behavioural conditions. This article is part of the 60th Anniversary special issue.

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Insulin induces phosphorylation of the AMPA receptor subunit GluR1, reversed by ZIP, and over‐expression of Protein Kinase M zeta, reversed by amyloid beta

Cited by 37 publications

References 49 publications

Protective Effects of Cerebrospinal Fluid With The Intake of Xixin Decoction on Hippocampal Neuron Apoptosis Induced by Aβ1-42

Protective Effects of Cerebrospinal Fluid With The Intake of Xixin Decoction on Hippocampal Neuron Apoptosis Induced by Aβ1-42

The Impact of Microbiota-Gut-Brain Axis on Diabetic Cognition Impairment

Synaptic signalling and its interface with neuropathologies: snapshots from the past, present and future

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