Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women

Gunter, Marc J.; Hoover, Donald R.; Yu, Herbert; Wassertheil‐Smoller, Sylvia; Rohan, Thomas E.; Manson, JoAnn E.; Howard, Barbara V.; Wylie‐Rosett, Judith; Anderson, Garnet L.; Ho, Gloria Y.F.; Kaplan, Robert C.; Li, Jixin; Xue, Xiaonan; Harris, Tiffany G.; Burk, Robert D.; Strickler, Howard D.

doi:10.1158/0008-5472.can-07-2946

Cited by 197 publications

(199 citation statements)

References 44 publications

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“…OCC hormones may also suppress of insulin like growth factor I and synthesis or secretion of bile acids, which are inversely associated with the risk of CRC [28].…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Risk Associated with Reproductive Factors among Turkish Women

Baran¹,

PÄ±nar²,

Åahin³

2016

Reprod Syst Sex Disord

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Purpose: Our aim was to investigate the association between the female reproductive factors and colorectal cancer risk (CRC).Methods: This descriptive and cross-sectional study was conducted with 196 women (50 years old and older) at Ankara Keçiören Training and Research Hospital (AKEAH), Maternity Polyclinic during June 16-July 30 2014 in Turkey. A Survey Form was used in data collection.Results: Mean age of women who were included in the research scope was 57.2 ± 7.9. It was determined that 85.7% of women were not informed about CRC screening methods and 86.2% did not have CRC screening test. 83.6% of women were at low risk group for CRC, and approximately two out of five persons (16.4%) were in moderate risk group. We observed that presence of gynecological cancer; bowel disease, chronic disease and family history of bowel disease were associated with CRC risk (p<0.05). We observed no statistically significant associations between use of oral contraceptive and hormone therapy, menarche age, age at first birth, parity, menopausal age (p>0.05). Conclusion:This study supports the assumption that there might be an association between reproductive factors and risk of CRC. Wider screening of risk factors should be explored in further.

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“…OCC hormones may also suppress of insulin like growth factor I and synthesis or secretion of bile acids, which are inversely associated with the risk of CRC [28].…”

Section: Discussionmentioning

confidence: 99%

Colorectal Cancer Risk Associated with Reproductive Factors among Turkish Women

Baran¹,

PÄ±nar²,

Åahin³

2016

Reprod Syst Sex Disord

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“…IR is a condition in which the body produces sufficient insulin to take up and use glucose, but the sensitivity to this insulin is impaired or selective, thus causing pancreatic b-cells to upregulate insulin production as a compensatory mechanism, which results in hyperinsulinemia. There are several studies linking hyperinsulinemia and the risk and/or aggressiveness of colorectal, pancreatic, liver, esophageal, breast, and endometrial cancers (Gunter et al 2008, Arcidiacono et al 2012, Inoue & Tsugane 2012, Qiu et al 2012, Zhan et al 2013. Thyroid nodules follow the same trend (Rezzonico et al 2008).…”

Section: Ir and The Role Of Igf1mentioning

confidence: 99%

Obesity and thyroid cancer

Marcello,

Cunha,

Batista

et al. 2014

Endocrine Related Cancer

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Many studies have provided observational data on the association of obesity and thyroid cancers, but only few of them propose mechanisms that would permit a better understanding of the causal molecular mechanisms of this association. Considering that there is an increasing incidence of both obesity and thyroid cancers, we need to summarize and link recent studies in order to characterize and understand the contribution of obesity-related factors that might affect thyroid cancer development and progression. Adipose tissue is involved in many vital processes, including insulin sensitivity, angiogenesis, regulation of energy balance, activation of the complement system, and responses such as inflammation. Although these processes have their own molecular pathways, they involve the same molecules through which obesity and adipose tissue might exert their roles in carcinogenesis, not only affecting MAPK and PI3K or even insulin pathways, but also recruiting local inflammatory responses that could result in disease formation and progression. This review describes five important issues that might explain the link between excessive weight and thyroid cancer: thyroid hormones, insulin resistance, adipokines, inflammation, and sexual hormones.

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“…A small number of prospective epidemiologic studies have looked at IGF-I and IGFBP-3 as risk factors for of colorectal cancer (7)(8)(9)(10)(11)(12)(13)(14). These studies have generally indicated an increased risk of disease with higher concentrations of IGF-I, although only two of these results (7,9) were statistically significant.…”

Section: Introductionmentioning

confidence: 99%

“…These studies have generally indicated an increased risk of disease with higher concentrations of IGF-I, although only two of these results (7,9) were statistically significant. For IGFBP-3, the picture is considerably less clear with two studies showing strong inverse associations (7,9), whereas most others produced results suggestive of positive associations between IGFBP-3 concentration and incident colorectal cancer (7)(8)(9)(10)(11)(12)(13)(14). Only one study has looked prospectively at colorectal adenomas, and although Giovannucci and colleagues (7) found no evidence that elevated IGF-I or IGFBP-3 were associated with nonadvanced adenomas, they did observe strong associations between each of these serum measures and advanced adenoma.…”

Section: Introductionmentioning

confidence: 99%

Serum Concentrations of Insulin-Like Growth Factor and Insulin-Like Growth Factor Binding Protein 3 and Recurrent Colorectal Adenomas

Flood¹,

Mai²,

Pfeiffer³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Insulin-like growth factor I (IGF-I) and its primary binding protein, IGFBP-3, have been associated with colorectal cancer incidence in prior epidemiologic studies. High concentrations of IGF-I generally result in increasing risk and high concentrations of IGFBP-3 in decreasing risk. Only one prior study of IGF-I and IGFBP-3 and adenoma recurrence has been reported. We assayed fasting serum from 375 subjects with and 375 subjects without a recurrent adenoma during the course of the Polyp Prevention Trial to determine baseline concentrations of IGF-I and IGFBP-3. To estimate relative risk of adenoma recurrence over the course of 4 years of follow-up for each of these serum measures, we calculated odds ratios (OR) and 95% confidence intervals (CI) using multivariable logistic regression models adjusting for age, gender, body mass index, intervention group, aspirin, smoking, ethnicity, and education. For both IGF-I and IGFBP-3, we found trends indicating decreased risk for subjects in the high compared with the low quartile (for IGF-I: OR, 0.65; 95% CI 0.41-1.01; for IGFBP-3: OR, 0.66; 95% CI, 0.42-1.05). The associations were even greater for advanced adenomas (for IGF-I: OR, 0.51; 95% CI, 0.21-1.29; for IGFBP-3: OR, 0.32; 95% CI, 0.13-0.82). These results showed an unexpected null association, or even the suggestion of a reduction in risk for recurrent adenoma, with not just high IGFBP-3 concentration but also with high levels of IGF-I. Why IGF-I would decrease risk of recurrent adenoma (as distinct from incident adenoma or colorectal cancer) is not clear. (Cancer Epidemiol Biomarkers Prev 2008;17(6):1493 -8)

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Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women

Cited by 197 publications

References 44 publications

Colorectal Cancer Risk Associated with Reproductive Factors among Turkish Women

Colorectal Cancer Risk Associated with Reproductive Factors among Turkish Women

Obesity and thyroid cancer

Serum Concentrations of Insulin-Like Growth Factor and Insulin-Like Growth Factor Binding Protein 3 and Recurrent Colorectal Adenomas

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