Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury

Slavin, Benjamin R.; Sarhane, Karim A.; Guionneau, Nicholas von; Hanwright, Phillip J.; Qiu, Chenhu; Mao, Hai Quan; Höke, Ahmet; Tuffaha, Sami H.

doi:10.3389/fbioe.2021.695850

Cited by 35 publications

(22 citation statements)

References 105 publications

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“…In this study, we identified IGF1 as a key endogenous signaling molecule secreted by human SFRP4 + stromal cells during the regenerative phase of the menstrual cycle, which regenerates endometrial epithelial organoid formation in vitro, gland formation in vivo and full-thickness endometrial regeneration. This identification provided a promising bioactive molecule for tissue engineering and regenerative medicine treatment of endometrial injury, thin endometria, and intrauterine adhesion, as IGF1 was reported to be functional in the treatment of injury in peripheral Nerve 31 and cartilage reconstruction in Osteoarthritis 32 . In addition to its role in the endometrial epithelia, IGF1 was also shown to promote interleukin 10 (IL10) expression in bone marrow stem cells, which suggests additional functions of IGF1 in immune regulation 33 .…”

Section: Discussionmentioning

confidence: 99%

SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration

Nie

et al. 2022

Cell Discov

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Our understanding of full-thickness endometrial regeneration after injury is limited by an incomplete molecular characterization of the cell populations responsible for the organ functions. To help fill this knowledge gap, we characterized 10,551 cells of full-thickness normal human uterine from two menstrual phases (proliferative and secretory phase) using unbiased single cell RNA-sequencing. We dissected cell heterogeneity of main cell types (epithelial, stromal, endothelial, and immune cells) of the full thickness uterine tissues, cell population architectures of human uterus cells across the menstrual cycle. We identified an SFRP4+ stromal cell subpopulation that was highly enriched in the regenerative stage of the human endometria during the menstrual cycle, and the SFRP4+ stromal cells could significantly enhance the proliferation of human endometrial epithelial organoid in vitro, and promote the regeneration of endometrial epithelial glands and full-thickness endometrial injury through IGF1 signaling pathway in vivo. Our cell atlas of full-thickness uterine tissues revealed the cellular heterogeneities, cell population architectures, and their cell–cell communications during the monthly regeneration of the human endometria, which provide insight into the biology of human endometrial regeneration and the development of regenerative medicine treatments against endometrial damage and intrauterine adhesion.

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Section: Discussionmentioning

confidence: 99%

SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration

Nie

et al. 2022

Cell Discov

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“…Elevation of Igf‐1, a growth hormone and associated with tissue regeneration and repair (Slavin et al, 2021), in CPZ‐fed C57Bl/6 mice coincides with the appearance of OPC, suggesting a protective role for Igf‐1 (Mason et al, 2000). While the source of Igf‐1 was not investigated in that study (Mason et al, 2000), another study revealed that the astrocytic expression of Igf‐1 was associated with remyelination (Schulz et al, 2012).…”

Section: Microglial Role In Myelination Following Cns Injurymentioning

confidence: 99%

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

Sen

Mahns

Coorssen

et al. 2022

Glia

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In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between demyelination and remyelination can trigger progressive degenerative processes. The clearance of myelin debris (phagocytosis) from the site of demyelination by microglia is critically important to achieve adequate remyelination and to slow the progression of the disease. However, how microglia phagocytose the myelin debris, and why clearance is impaired in MS, is not fully known; likewise, the role of the microglia in remyelination remains unclear. Recent studies using cuprizone (CPZ) as an animal model of central nervous system demyelination revealed that the up‐regulation of signaling proteins in microglia facilitates effective phagocytosis of myelin debris. Moreover, during demyelination, protective mediators are released from activated microglia, resulting in the acceleration of remyelination in the CPZ model. In contrast, inadequate microglial activation or recruitment to the site of demyelination, and the production of toxic mediators, impairs remyelination resulting in progressive demyelination. In addition to the microglia‐mediated phagocytosis, astrocytes play an important role in the phagocytic process by recruiting microglia to the site of demyelination and producing regenerative mediators. The current review is an update of these emerging findings from the CPZ animal model, discussing the roles of microglia and astrocytes in phagocytosis and myelination.

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“…Schwann cells play an irreplaceable role during NMJ regeneration since they could guide axons to achieve the original NMJs sites and remyelinate them ( Gordon, 2020 ; Nocera and Jacob, 2020 ). The GH-IGF-1 system has been proven to have the potential to improve outcomes after the nerve injury ( Tuffaha et al, 2016 ; Lopez et al, 2019 ; Slavin et al, 2021 ). Also, it has been demonstrated that during the regeneration period, GH and IGF-1 support SCs myelination and inhibit SCs apoptosis.…”

Section: Neuromuscular Junction Protection Strategies and Their Clini...mentioning

confidence: 99%

Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

Huang

Jiang

2022

Front. Mol. Neurosci.

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Neuromuscular junctions (NMJs) are the key interface between terminal nerves and targeted muscle, which undergo degeneration during denervation periods. Denervation-related NMJs changes limits the recovery level of nerve repair strategies. Insights into mechanisms behind neuromuscular junction degeneration and regeneration, following denervation and reinnervation, are of clinical value. Developing some therapies to maintain or protect structures and functions of NMJs may contribute to a better prognosis. Here, we reviewed previous studies of NMJs focusing on the morphological, functional, and molecular changes after denervation, and if those changes can be reversed after reinnervation. Also, we reviewed about the present probable strategies that have been applied clinically or could still be studied in targeting the neuromuscular junction protection or regeneration improvement.

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Insulin-Like Growth Factor-1: A Promising Therapeutic Target for Peripheral Nerve Injury

Cited by 35 publications

References 105 publications

SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration

SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration

The roles of microglia and astrocytes in phagocytosis and myelination: Insights from the cuprizone model of multiple sclerosis

Denervation-Related Neuromuscular Junction Changes: From Degeneration to Regeneration

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