AIM: To assess the effect of postnatal weight gain (WG) characteristics and multiple risk factors on treatment-required retinopathy of prematurity (ROP).
METHODS: The medical records of preterm infants who were followed up for ROP in a tertiary referral center were retrospectively reviewed. Infants were grouped as Treatment(-) (retinal maturation without treatment) and Treatment(+) (treatment required). ROP findings, WG and WG rates at the 4th and 6th weeks, and clinical features were recorded. The best cut-off points for the WG and WG rate were assessed with the area under the receiver operating characteristic curve (AUC). Risk factors were determined by the logistic regression model.
RESULTS: Twenty-eight of 201 preterm infants (13.5%) were in the Treatment(+) group. Birth weight, gestational age, WG, and WG rate at the 4th and 6th weeks were lower, the duration of oxygen therapy and hospitalization was longer, and a history of bronchopulmonary dysplasia (BPD), necrotizing enterocolitis, prolonged mechanical ventilation (MV) and erythrocyte transfusion was more common in the Treatment(+) group (p