Insulin-like growth factor 1 (IGF1) affects proliferation and differentiation and wound healing processes in an inflammatory environment with p38 controlling early osteoblast differentiation in periodontal ligament cells

Reckenbeil, Jan; Kraus, Dominik; Stark, Helmut; Rath-Deschner, Birgit; Jäger, Andreas; Wenghoefer, Matthias; Winter, Jochen; Götz, Werner

doi:10.1016/j.archoralbio.2016.10.010

Cited by 18 publications

(13 citation statements)

References 47 publications

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“…MDM2 is considered as a negative regulator of p53 [ 5 ]. Amplification of MDM2 genes and/or enhanced expression of MDM2 is observed in a variety of tumors including GCT [ 6 ]. IGF-1, which regulates cell proliferation, plays a key role in osteoblast proliferation and bone formation [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone

Chen

et al. 2018

Journal of Immunology Research

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Background In our previous study, mouse double minute 2 homolog (MDM2), insulin-like growth factor 1 (IGF1), signal transducer and activator of transcription 1 (STAT1), and Rac family small GTPase 1 (RAC1) were correlated with the recurrence of giant cell tumor of bone (GCT). The aim of this study is to use a large cohort study to confirm the involvement of these four genes in GCT recurrence. Methods The expression of these four genes was detected and compared between GCT patients with or without recurrence. The correlation between the expression of these four genes and clinical characteristics was evaluated. Protein-protein interaction (PPI) network was constructed for functional enrichment analysis. Results It showed that the expression levels of MDM2, IGF1, STAT1, and RAC1 in GCT patients with recurrence were significantly higher than those in GCT patients without recurrence (P < 0.05). Multivariate logistic regression analysis suggested that several clinical characteristics may influence prognosis. A PPI network was constructed using the four genes as hub genes. Functional enrichment analysis showed that this network involves many important biological progress mediated by these four genes, including immune response. Conclusion MDM2, IGF1, STAT1, and RAC1 are associated with GCT recurrence, which might serve as biomarkers for GCT recurrence.

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Section: Introductionmentioning

confidence: 99%

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone

Chen

et al. 2018

Journal of Immunology Research

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“…Arginine, proline, leucine, and phenylalanine can enhance the effect of insulin-like growth factor 1 (Liu et al, 2008;Yang et al, 2010) (IGF-1), which can promote the proliferation and differentiation of osteoblasts (Zhang et al, 2012;Reckenbeil et al, 2017). Creatine is mainly synthesized by arginine, glycine and methionine in the liver.…”

Section: Discussionmentioning

confidence: 99%

Unveiling the Pharmacological Mechanisms of Eleutheroside E Against Postmenopausal Osteoporosis Through UPLC-Q/TOF-MS-Based Metabolomics

Hou

You

et al. 2020

Front. Pharmacol.

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Postmenopausal osteoporosis (PMOP) is a common metabolic bone disease in postmenopausal women in the Worldwide, and seriously affects the quality of life of middle-aged and elderly women. Therefore, there is an urgent need to discover a highly effective drug for PMOP treatment. In this study, ultra-high performance liquid tandem quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS) was used to analyze the urine metabolic profiling and potential biomarkers, the relevant metabolic network of PMOP rats, and further to evaluate the intervention effect of Eleutheroside E (EE) against PMOP. Using multivariate statistical analysis combined with UPLC-Q/TOF-MS, a total of 27 biomarkers were identified, which related with 16 metabolic pathways, mainly involving steroidogenesis, beta oxidation of very long chain fatty acids, glutathione metabolism, carnitine synthesis, estrone metabolism, oxidation of branched chain fatty acids, etc. After treatment of EE, these biomarkers were markedly regulated, mainly involving steroid hormone biosynthesis, arachidonic acid metabolism, primary bile acid biosynthesis, indicating that EE had the therapeutic effect on PMOP. This study identified the potential urine metabolic markers and related metabolic pathways of the PMOP, explained the metabolic effect and pharmacological mechanisms of EE against PMOP, and provided a basis for the pharmacological study of EE.

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“…The more deposition of collagen fibers stained by Masson Trichrome in Mix group compared to Dex group at Day 14 also supported the theory that Cr 3+ may restore the DEX-induced IGF-I attenuation and promote skin wound healing process in this study. (Reckenbeil et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…In fact, we have documented Cr3+ has an inhibitory effect on the corticosterone secretion by adrenal gland in ACTH-stimulated rats (King et al, 2016). In addition, Insulin-like growth factor-I (IGF-I) can be helpful on wound healing (Cieszkowski et al, 2017) which associated with proliferation, differentiation as well as wound healing process (Reckenbeil et al, 2017). Likewise, IGF-1 can be suppressed by glucocorticoids (Wolthers et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Trivalent Chromium Restore Dexamethasone-Induced Attenuation Effect of Insulin-Like Growth Factor-1 and Promote Skin Wound Healing in Mice

Hsieh¹

2019

PVJ

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This study was conducted to investigate the effects of Cr 3+ on wound healing in mice. A total of 96 male C57BL6/J mice were randomly assigned to four groups (n=24/group). These mice were divided 4 groups and treated by normal saline, chromium chloride (CrCl3), dexamethasone (Dex) as well as combination of CrCl3 and Dex, respectively. Six mice of each group were sacrificed on day 7, 14, and 21 after skin incision. Skin wound area were measured and collected for histology evaluation, tissue of organs was collected for Cr 3+ concentration determination as well as blood collected for serum IGF-I concentrations determination. Delayed healing was found in Dex group, and an accelerated healing was observed in both Cr groups. In histology, the delayed inflammation process, reepithelization, granulation tissue formation as well as collagen deposition were observed in Dex groups. However, reversed detrimental effects of Dex were observed in Cr groups. The concentrations of IGF-1 in Dex groups revealed significant decrement compared to other groups, but Cr 3+ reversed this effect. Therefore, Cr 3+ accelerated wound healing in surgical wound model of mice through the regulation of hormone concentrations such as IGF-1, meanwhile, the effects could be more prominent when animal is under stress or treated by exogenous glucocorticoids. ©2019 PVJ. All rights reserved Key words:Dexamethasone Healing Insulin-like growth factor-1 Mice Trivalent chromium Wound To Cite This Article: Hsieh YT, Hsu TH, Wang HC, Chen KS and Lee WM, 2019. Trivalent chromium restore dexamethasone-induced attenuation effect of insulin-like growth factor-1 and promote skin wound healing in mice. Pak Vet J, 39(2): 199-204. http://dx.

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Insulin-like growth factor 1 (IGF1) affects proliferation and differentiation and wound healing processes in an inflammatory environment with p38 controlling early osteoblast differentiation in periodontal ligament cells

Cited by 18 publications

References 47 publications

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone

STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone

Unveiling the Pharmacological Mechanisms of Eleutheroside E Against Postmenopausal Osteoporosis Through UPLC-Q/TOF-MS-Based Metabolomics

Trivalent Chromium Restore Dexamethasone-Induced Attenuation Effect of Insulin-Like Growth Factor-1 and Promote Skin Wound Healing in Mice

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