Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

Fukuda, Ryo; Hirota, Kiichi; Fan, Fan; Jung, Young Do; Ellis, Lee M.; Semenza, Gregg L.

doi:10.1074/jbc.m203781200

Cited by 733 publications

(689 citation statements)

References 37 publications

Supporting

Mentioning

616

Contrasting

Unclassified

Order By: Relevance

“…IGF‐1 induced VEGF expression in colon and prostate cancer directly and/or indirectly mediated by HIF‐1a 56, 57, 58. What is worth noting, previous reports revealed that there existed a positive feedback mechanism between IGF‐1 and HIF‐1 regulating the interaction of tumour and HUVECs and promoting angiogenesis 56, 59, 60. Our results demonstrate that basigin‐2 could positively regulate the secretion of IGF‐1 from microglia.…”

Section: Discussionsupporting

confidence: 55%

Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis

Yin

et al. 2017

J Cellular Molecular Medi

View full text Add to dashboard Cite

Retinal microglia cells contribute to vascular angiogenesis and vasculopathy induced by relative hypoxia. However, its concrete molecular mechanisms in shaping retinal angiogenesis have not been elucidated. Basigin, being involved in tumour neovasculogenesis, is explored to exert positive effects on retinal angiogenesis induced by microglia. Therefore, we set out to investigate the expression of basigin using a well‐characterized mouse model of oxygen‐induced retinopathy, which recapitulated hypoxia‐induced aberrant neovessel growth. Our results elucidate that basigin is overexpressed in microglia, which accumulating in retinal angiogenic sprouts. In vitro, conditioned media from microglia BV2 under hypoxia treatment increase migration and tube formation of retinal capillary endothelia cells, compared with media from normoxic condition. The angiogenic capacity of BV2 is inhibited after basigin knockdown by small interfering RNAs. A new molecular mechanism for high angiogenic capacity, whereby microglia cells release basigin via up‐regulation of PI3K‐AKT and IGF‐1 pathway to induce angiogenesis is unveiled. Collectively, our results demonstrate that basigin from hypoxic microglia plays a pivotal pro‐angiogenic role, providing new insights into microglia‐promoting retinal angiogenesis.

show abstract

Section: Discussionsupporting

confidence: 55%

Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis

Yin

et al. 2017

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Interestingly, several known hypoxia-activated genes, such as those encoding proteins involved in glucose metabolism like Glut1, are also regulated by growth factor signaling and by notch signaling, indicating a crosstalk between those pathways (Zelzer et al, 1998;Vander Heiden et al, 2001;Fukuda et al, 2002;Ciofani and Zuniga-Pflucker, 2005). Therefore, oxygen concentration should be taken into account in the forthcoming studies on cellular differentiation.…”

Section: Discussionmentioning

confidence: 99%

Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation

et al. 2006

View full text Add to dashboard Cite

The transcription factor hypoxia inducible factor 1 (HIF1), an HIF1a-aryl hydrocarbon receptor nuclear translocator (ARNT) dimeric factor, is essential to the cellular response to hypoxia. We described a t(1;12)(q21;p13) chromosomal translocation in human acute myeloblastic leukemia that involves the translocated Ets leukemia (TEL/ETV6) and the ARNT genes and results in the expression of a TEL-ARNT fusion protein.Functional studies show that TEL-ARNT interacts with HIF1a and the complex binds to consensus hypoxia response element. In low oxygen tension conditions, the HIF1a/TEL-ARNT complex does not activate transcription but exerts a dominant-negative effect on normal HIF1 activity. Differentiation of normal human CD34 þ progenitors cells along all the erythrocytic, megakaryocytic and granulocytic pathways was accelerated in low versus high oxygen tension conditions. Murine 32Dcl3 myeloid cells also show accelerated granulocytic differentiation in low oxygen tension in response to granulocyte colony-stimulating factor. Interestingly, stable expression of the TEL-ARNT in 32Dcl3 subclones resulted in impaired HIF1-mediated transcriptional response and inhibition of differentiation enhancement in hypoxic conditions. Taken together, our results underscore the role of oxygen tension in the modulation of normal hematopoietic differentiation, whose targeting can participate in human malignancies.

show abstract

“…47 Hypoxia, via HIF-1a signalling, is the most potent stimulus for induction of VEGF. HIF-1a regulates both hypoxia-and growth factor-induced VEGF expression in tumour cells, and genetic manipulation in human tumour xenograft models has established causal relationships between the level of HIF-1 activity, tumour growth and angiogenesis, 48 although non-HIF-1a-mediated signalling pathways may also be involved. 49 It has recently been shown that upregulation of HIF-1a is an early event in prostate carcinogenesis, which suggests that it may serve as a surrogate marker for detecting premalignant lesions of the prostate.…”

Section: Angiogenesismentioning

confidence: 99%

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade

Woodward

Wachsberger

Burd

et al. 2005

Prostate Cancer Prostatic Dis

View full text Add to dashboard Cite

Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells

Cited by 733 publications

References 37 publications

Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis

Up‐regulated basigin‐2 in microglia induced by hypoxia promotes retinal angiogenesis

Functional analyses of the TEL-ARNT fusion protein underscores a role for oxygen tension in hematopoietic cellular differentiation

Effects of androgen suppression and radiation on prostate cancer suggest a role for angiogenesis blockade

Contact Info

Product

Resources

About