2001
DOI: 10.1097/00004647-200105000-00003
|View full text |Cite
|
Sign up to set email alerts
|

Insulin-Like Growth Factor-1 Reduces Postischemic White Matter Injury in Fetal Sheep

Abstract: Insulin-like growth factor-1 (IGF-1) is known to be important for oligodendrocyte survival and myelination. In the current study, the authors examined the hypothesis that exogenous IGF-1 could reduce postischemic white matter injury. Bilateral brain injury was induced in near-term fetal sheep by 30 minutes of reversible carotid artery occlusion. Ninety minutes after ischemia, either vehicle (n = 8) or a single dose of 3 microg IGF-1 (n = 9) was infused intracerebroventricularly over 1 hour. White matter change… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

10
98
0
1

Year Published

2002
2002
2014
2014

Publication Types

Select...
8

Relationship

1
7

Authors

Journals

citations
Cited by 105 publications
(109 citation statements)
references
References 47 publications
10
98
0
1
Order By: Relevance
“…Consistent with these concepts, when 1-wk-old rat pups were exposed to an acute hypoxic-ischemic insult, degenerative changes were observed in the preoligodendrocyte detected by antibody to O4 (6). In a recent study (11), a positive correlation was found between the number of PLP mRNA-positive cells and MBP staining in late-gestation fetal sheep subjected to 30 min of bilateral carotid artery occlusion and 96 h of reperfusion. Similar to these findings, we found a dramatic decrease in immunocytochemically detectable MBP along with lesions within the Luxol fast blue-stained deep white matter.…”
Section: Discussionsupporting
confidence: 59%
See 2 more Smart Citations
“…Consistent with these concepts, when 1-wk-old rat pups were exposed to an acute hypoxic-ischemic insult, degenerative changes were observed in the preoligodendrocyte detected by antibody to O4 (6). In a recent study (11), a positive correlation was found between the number of PLP mRNA-positive cells and MBP staining in late-gestation fetal sheep subjected to 30 min of bilateral carotid artery occlusion and 96 h of reperfusion. Similar to these findings, we found a dramatic decrease in immunocytochemically detectable MBP along with lesions within the Luxol fast blue-stained deep white matter.…”
Section: Discussionsupporting
confidence: 59%
“…Although the methodology of Reddy et al (12) might have detected the more severe lesions, it remains possible that the more subtle but consistent lesions that we identified in the deep white matter might have been missed by their analysis. In support of this contention, in a recent study from the same laboratory, when immunohistochemical methods were used to detect the presence and appearance of MBP, a loss of MBP from the white matter was identified in ovine fetuses at 85% gestation that had been exposed to 30 min of bilateral carotid occlusion and 96 h of reperfusion (11).…”
Section: Discussionmentioning
confidence: 85%
See 1 more Smart Citation
“…It was demonstrated by Inoue et al [55] that IGF-I increased the killing capacity and phagocytosis of peritoneal macrophages when they were activated by E coli. IGF-I expression in AMC may also have paracrine functions, such as the modulation of the proliferation and development of the oligodendrocytes and myelination, as it has been considered as an important factor for oligodendrocyte survival and myelination [56,57] . Although the exact function of IGF-II in the developing brain is not clear, its pattern of association with oligodendrocytes and myelin suggests that it may also play a role in myelination [58,59] or in the phagocytic activity of AMC.…”
Section: Nature Of Amcmentioning
confidence: 99%
“…[1][2][3] Although current management is limited to supportive therapy, several strategies to minimize post-asphyxia morbidity are under investigation. [4][5][6][7][8][9][10][11][12] Hypothermia has been investigated in randomized controlled trials with apparent neuroprotective benefit in term infants with HIE. In order to be effective, hypothermia must be initiated within a maximum of 6 h after birth, with earlier initiation being associated with better outcome.…”
Section: Introductionmentioning
confidence: 99%