Insulin-like growth factor-1 short-period therapy stimulates bone marrow cells in obese swiss mice

Oliveira, Gustavo P.; Andrade, Daniela Caldas de; Nascimento, Ana Lúcia Rosa; Cortez, Erika; Carvalho, Simone; Stumbo, Ana Carolina; Garcia-Souza, Érica Patrícia; Moura, Aníbal Sanchez; Carvalho, Laís de; Thole, Alessandra Alves

doi:10.1007/s00441-020-03357-9

Cell Tissue Res

2021

DOI: 10.1007/s00441-020-03357-9

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Insulin-like growth factor-1 short-period therapy stimulates bone marrow cells in obese swiss mice

Gustavo P. Oliveira

Daniela Caldas de Andrade

Ana Lúcia Rosa Nascimento

et al.

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2024

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Cited by 2 publications

References 40 publications

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IGF signaling pathway in bone and cartilage development, homeostasis, and disease

Ruan,

Jin,

Sun

et al. 2024

The FASEB Journal

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The skeleton plays a fundamental role in the maintenance of organ function and daily activities. The insulin‐like growth factor (IGF) family is a group of polypeptide substances with a pronounced role in osteoblast differentiation, bone development, and metabolism. Disturbance of the IGFs and the IGF signaling pathway is inextricably linked with assorted developmental defects, growth irregularities, and jeopardized skeletal structure. Recent findings have illustrated the significance of the action of the IGF signaling pathway via growth factors and receptors and its interactions with dissimilar signaling pathways (Wnt/β‐catenin, BMP, TGF‐β, and Hh/PTH signaling pathways) in promoting the growth, survival, and differentiation of osteoblasts. IGF signaling also exhibits profound influences on cartilage and bone development and skeletal homeostasis via versatile cell–cell interactions in an autocrine, paracrine, and endocrine manner systemically and locally. Our review summarizes the role and regulatory function as well as a potentially integrated gene network of the IGF signaling pathway with other signaling pathways in bone and cartilage development and skeletal homeostasis, which in turn provides an enlightening insight into visualizing bright molecular targets to be eligible for designing effective drugs to handle bone diseases and maladies, such as osteoporosis, osteoarthritis, and dwarfism.

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IGF signaling pathway in bone and cartilage development, homeostasis, and disease

Ruan,

Jin,

Sun

et al. 2024

The FASEB Journal

View full text Add to dashboard Cite

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Are the Properties of Bone Marrow-Derived Mesenchymal Stem Cells Influenced by Overweight and Obesity?

Zong

Bundkirchen

Neunaber

et al. 2023

IJMS

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Bone marrow-derived mesenchymal stem cells (BMSCs) are promising candidates for cell-based therapies. Growing evidence has indicated that overweight/obesity can change the bone marrow microenvironment, which affects some properties of BMSCs. As the overweight/obese population rapidly increases, they will inevitably become a potential source of BMSCs for clinical application, especially when receiving autologous BMSC transplantation. Given this situation, the quality control of these cells has become particularly important. Therefore, it is urgent to characterize BMSCs isolated from overweight/obese bone marrow environments. In this review, we summarize the evidence of the effects of overweight/obesity on the biological properties of BMSCs derived from humans and animals, including proliferation, clonogenicity, surface antigen expression, senescence, apoptosis, and trilineage differentiation, as well as the underlying mechanisms. Overall, the conclusions of existing studies are not consistent. Most studies demonstrate that overweight/obesity can influence one or more characteristics of BMSCs, while the involved mechanisms are still unclear. Moreover, insufficient evidence proves that weight loss or other interventions can rescue these qualities to baseline status. Thus, further research should address these issues and prioritize developing methods to improve functions of overweight- or obesity-derived BMSCs.

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Insulin-like growth factor-1 short-period therapy stimulates bone marrow cells in obese swiss mice

Cited by 2 publications

References 40 publications

IGF signaling pathway in bone and cartilage development, homeostasis, and disease

IGF signaling pathway in bone and cartilage development, homeostasis, and disease

Are the Properties of Bone Marrow-Derived Mesenchymal Stem Cells Influenced by Overweight and Obesity?

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