Insulin-like growth factor-binding protein-1 in cervical secretion as a predictor of preterm delivery

Abstract

Pregnant women who are in preterm labor with intact fetal membranes and who have a positive phIGFBP-1 test result in cervical secretion have an increased risk of preterm delivery.

Decreased placental expression of hPGH, IGF-I and IGFBP-1 in pregnancies complicated by fetal growth restriction

“…In a study by the expression of IGF-I and IGFBP-1 gene in the placenta decreases from 35-37 weeks to 38-40 weeks [47]. In pregnancies complicated with preterm delivery decreased levels of IGFBP-1 in placental extracts [48] increased levels of IGFBP-1 in cervical secretion, and the amniotic fluid [49][50][51] and decreased IGFBP-3 concentrations in the maternal circulation [52] have been found. This may reflect changes in the placental expression of these genes, which, however, has not yet been investigated.…”

Insulin-like growth factor-binding protein-1 (IGFBP-1) in cervical secretions as a predictor of preterm delivery

“…The same conclusion was reached by another group [16] who tested the reliability of the Actim Partus test in predicting preterm deliveries. Kekki et al [17] also discussed the high negative predictive value of determining IGFBP-1, and Bittar [18] also tested pregnant women without symptoms of preterm delivery and found that the sensitivity of the test was 83%, positive predictive value 63%, specificity 80%, and negative predictive value 92%. Similar results of high specificity and negative predictive value in asymptomatic pregnant women were shown in other studies published last year [19,20,21,22].…”

Biochemistry testing associated with pregnancy and the newborn period—A lot has changed since you were a baby!

“…IGFBP-1 and phIGFBP-1 can be differentiated by the use of unique antibodies [135]. Consequently, the presence of IGFBP-1 can be used to detect PROM and the presence of phIGFBP-1 to predict preterm labor [136,137]. In addition, measurement of phIGFBP-1 from cervical secretions can also be used to estimate the ripeness of the cervix [138].…”