Insulin-like Growth Factor I and Leptin in Umbilical Cord Plasma and Infant Birth Size at Term

Vatten, Lars J.; Nilsen, Stein Tore; Ødegård, Rønnaug; Romundstad, Pål Richard; Austgulen, Rigmor

doi:10.1542/peds.109.6.1131

Cited by 136 publications

(113 citation statements)

References 24 publications

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“…This has been suggested to be a signal of adequate weight gain (20,26). The positive independent correlation of IGF1 with neonatal weight and the lower IGF1 and IGFBP-3 levels in SGA compared with AGA newborns found confirm previous reports by our group (9), and reinforce the postulated role of these peptides in prenatal growth control.…”

Section: Discussionsupporting

confidence: 87%

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Martos‐Moreno¹,

Barrios²,

Pipaón³

et al. 2009

European Journal of Endocrinology

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Objective: To determine the influence of gestational age and fetal growth restriction on the cord blood adipokine profile, IGF1, and ghrelin levels, and their relationship with glucose metabolism. Study design: One hundred and ninety newborns (99 preterm and 91 full term) were studied and, according to their anthropometry at birth, classified as small (SGA) or adequate for gestational age (AGA). Methods: Venous cord blood serum levels of IGF1, IGF binding protein 3 (IGFBP-3), adiponectin, resistin, leptin, soluble leptin receptor (sOB-R), tumoral necrosis factor-a, interleukin 6 (IL-6), total ghrelin, and acylated ghrelin were determined and compared between preterm and full-term, as well as between SGA and AGA, newborns. Correlations with newborn weight, gestational age, and homeostatic model assessment (HOMA) index, as an index of insulin resistance, were determined. Results: Preterm newborns had higher HOMA, sOB-R, resistin, and IL-6 and lower IGF1, IGFBP-3, leptin, and adiponectin levels than full-term newborns. SGA had lower IGF1, IGFBP-3, leptin, IL-6, and adiponectin and higher sOB-R and total ghrelin than AGA newborns. Adiponectin and HOMA showed independent positive and negative correlations with gestational age respectively, but not with neonatal weight. Birth weight was correlated positively with IGF1 and leptin levels and negatively with total ghrelin ones. Conclusions: Our findings suggest that the lack of proper acquisition of adipose tissue by the fetus either due to prematurity or to fetal growth restriction is associated with changes in the cord blood adipokine profile that may contribute to the impairment of glucose metabolism.

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Section: Discussionsupporting

confidence: 87%

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Martos‐Moreno¹,

Barrios²,

Pipaón³

et al. 2009

European Journal of Endocrinology

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“…Entre esses hormônios estão: GH fetal, insulina, somatomedina, hormônios tireoidianos e esteróides sexuais 9 . Estudos recentes sugerem que a leptina também esteja envolvida nesse processo [10][11] .…”

Section: Resultsunclassified

Leptin as a marker of sexual dimorphism in newborn infants

I.M.C.G.¹,

Geloneze²,

Tambascia³

et al. 2004

J Pediatr (Rio J)

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Fonte financiadora: Fundação de Amparo à Pesquisa do Estado de São Paulo -FAPESP.Artigo submetido em 17.12.03, aceito em 26.04.04. AbstractObjective: To determine cord blood leptin levels in newborns appropriate for gestational age, according to gender, birth weight, birth height and ponderal index.Methods: A cross-sectional study was carried out with 132 term newborns appropriate for gestational age (68 females, 64 males), gestational age between 35-42 weeks. Data were collected through interviews with the mothers at the maternity, anthropometrycal study of the newborns, and cord blood estradiol, testosterone and leptin assays obtained immediately after birth.Results: The levels of leptin were significantly higher in females than in males (8.34±0.65 ng/ml versus 6.06±0.71 ng/ml; p = 0.000). The concentrations of estradiol and testosterone did not differ between males and females. Leptin levels were positively correlated with gestational age (r = 0.394, p < 0.01), birth weight (r = 0.466, p < 0.01), birth length (r = 0.335, p < 0.01) and ponderal index (r = 0.326, p < 0.01).Conclusions: Leptin concentration in the umbilical cord is positively correlated with gestational age, birth weight, birth height, and ponderal index, suggesting its participation in the neonatal growth process. In addition, a gender difference with higher levels of leptin in females neonates was observed, suggesting that the sexual dimorphism in relation to body composition already exists in newborns. ResumoObjetivo: Avaliar os níveis de leptina do cordão umbilical em recém-nascidos adequados para a idade gestacional conforme sexo, peso, comprimento e índice ponderal de nascimento.Método: Estudo tipo transversal, envolvendo 132 recém-nascidos adequados para idade gestacional (68 do sexo feminino, 64 do sexo masculino), com idade gestacional de 35-42 semanas. Os dados foram obtidos mediante entrevista com as mães na maternidade, pelo estudo antropométrico dos recém-nascidos e pela dosagem de leptina, estradiol e testosterona no cordão umbilical por meio da coleta imediata após o parto.Resultados: Os recém-nascidos do sexo feminino apresentaram níveis de leptina significativamente maiores que os do sexo masculino (8,34±0,65 ng/ml versus 6,06±0,71 ng/ml; p = 0,000). Os níveis de estradiol e testosterona não variaram conforme o sexo. A leptina se correlacionou positivamente com idade gestacional (r = 0,394, p < 0,01), peso (r = 0,466, p < 0,01), comprimento (r = 0,335, p < 0,01) e índice ponderal (r = 0,326, p < 0,01) dos recém-nascidos.Conclusões: A leptina do cordão umbilical se correlaciona positivamente com idade gestacional, peso, comprimento e índice ponderal do recém-nascido, sugerindo sua participação no processo de crescimento neonatal. Além disso, os recém-nascidos do sexo feminino têm níveis séricos de leptina maiores que os do sexo masculino, sugerindo que o dimorfismo sexual relacionado à composição corporal já possa existir em recém-nascidos. ARTIGO ORIGINAL IntroduçãoA leptina (palavra grega leptos, que significa magro ) é uma p...

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“…9 Recent studies have suggested that leptin may also be involved in this process. [10][11] Leptin levels can be measured in the amniotic fluid or in the umbilical cord after the 25th week of gestation. 5 Amniotic fluid leptin reflects the maternal environment, whereas umbilical cord leptin is derived from the placenta or from fetal tissue.…”

Section: Resultsmentioning

confidence: 99%

Leptina como marcadora do dimorfismo sexual em recém-nascidos

Pardo¹,

Geloneze²,

Tambascia³

et al. 2004

J. Pediatr. (Rio J.)

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Objective: To determine cord blood leptin levels in newborns appropriate for gestational age, according to gender, birth weight, birth height and ponderal index.Methods: A cross-sectional study was carried out with 132 term newborns appropriate for gestational age (68 females, 64 males), gestational age between 35-42 weeks. Data were collected through interviews with the mothers at the maternity, anthropometrycal study of the newborns, and cord blood estradiol, testosterone and leptin assays obtained immediately after birth.Results: The levels of leptin were significantly higher in females than in males (8.34±0.65 ng/ml versus 6.06±0.71 ng/ml; p = 0.000). The concentrations of estradiol and testosterone did not differ between males and females. Leptin levels were positively correlated with gestational age (r = 0.394, p < 0.01), birth weight (r = 0.466, p < 0.01), birth length (r = 0.335, p < 0.01) and ponderal index (r = 0.326, p < 0.01).Conclusions: Leptin concentration in the umbilical cord is positively correlated with gestational age, birth weight, birth height, and ponderal index, suggesting its participation in the neonatal growth process. In addition, a gender difference with higher levels of leptin in females neonates was observed, suggesting that the sexual dimorphism in relation to body composition already exists in newborns.

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Insulin-like Growth Factor I and Leptin in Umbilical Cord Plasma and Infant Birth Size at Term

Cited by 136 publications

References 24 publications

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Influence of prematurity and growth restriction on the adipokine profile, IGF1, and ghrelin levels in cord blood: relationship with glucose metabolism

Leptin as a marker of sexual dimorphism in newborn infants

Leptina como marcadora do dimorfismo sexual em recém-nascidos

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