Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes

Pascual, Mónica; Larralde, J; Martínez, Joseline

doi:10.1016/0024-3205(95)02067-s

Cited by 15 publications

(9 citation statements)

References 18 publications

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“…Moreover, LBM did not correlate with either urinary GH or serum IGFBP‐3 levels, although LBM exhibited a weakly positive correlation with serum IGF‐I concentration. Experiments in vitro with adipose tissue slices and isolated adipocytes have revealed a lipolytic action of GH and the presence of somatotrophic receptors on the cell membrane as well as an antilipolytic effect of IGF‐I on GH‐induced lipolysis (Goodman, 1965; Gavin et al ., 1973; Goodman & Kostyo, 1981; Pascual et al ., 1995), indicating direct antagonism between GH and IGF‐I on the lipolytic activity of adipocytes. Taken together with these findings, the present data suggest that GH decreases fat mass in a manner independent of the IGF‐I–IGFBP‐3 pathway in acromegaly.…”

Section: Discussionmentioning

confidence: 99%

Bone metabolism and body composition in Japanese patients with active acromegaly

Kaji

Sugimoto

Nakaoka

et al. 2001

Clinical Endocrinology

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The present study revealed that a decrease in percent fat mass and an increase in percent lean body mass were observed in Japanese patients with active acromegaly. Bone mineral density at all sites and bone metabolic markers were also increased in acromegaly. The present findings provide additional evidence that the GH/IGF-I axis might play an important role in the maintenance of bone mass as well as the regulation of body composition in Japanese adults.

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Section: Discussionmentioning

confidence: 99%

Bone metabolism and body composition in Japanese patients with active acromegaly

Kaji

Sugimoto

Nakaoka

et al. 2001

Clinical Endocrinology

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“…In vitro experiments with adipose tissue slices and isolated adipocytes have revealed a lipolytic action of GH and the presence of somatotropic receptors on the cell membrane as well as an anti-lipolytic effect of IGF-I on GH-induced lipolysis (25)(26)(27)(28), indicating a direct antagonistic action between GH and IGF-I on the lipolytic activity of adipocytes. Taken together, the present data suggest that GH negatively regulates fat mass not via the IGF-I-IGFBP-3 pathway and that IGF-I-IGFBP-3 positively regulates fat mass independently of GH.…”

Section: Figurementioning

confidence: 99%

Age-dependent changes in body composition in postmenopausal Japanese women: relationship to growth hormone secretion as well as serum levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3

Sugimoto

Nakaoka²,

Nasu³

et al. 1998

European Journal of Endocrinology

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The present study was performed to investigate the age-dependent changes in body composition and the possible role of growth hormone (GH), insulin-like growth factor (IGF)-I and IGF-binding protein-3 (IGFBP-3) in these changes in postmenopausal Japanese women. A total of 161 Japanese women aged 45-88 years (mean 62) were enrolled in the cross-sectional study. Body composition (bone mineral content (BMC), lean body mass (LBM) and fat) was measured by dual-energy X-ray absorptiometry, and the percentage of BMC, LBM and fat was calculated by dividing each absolute value of body composition by total body mass. Urinary GH concentration divided by creatinine in nocturnal urine samples collected just after waking was used as an index of endogenous GH secretion. Serum levels of IGF-I and IGFBP-3 were measured by RIA. Urinary GH levels as well as serum levels of IGF-I and IGFBP-3 declined with age. BMC, %BMC and LBM also declined with age, while fat mass and %fat did not obviously change with age. Urinary GH levels as well as serum levels of IGF-I and IGFBP-3 correlated positively with BMC, even if age was taken into account. On the other hand, urinary GH correlated negatively with fat and %fat. In contrast, serum levels of IGF-I and IGFBP-3 correlated positively with fat and %fat. LBM did not correlate with either urinary GH or serum IGFBP-3 levels but exhibited a weakly positive correlation with serum IGF-I level. The present study suggests that the GH-IGF-I-IGFBP-3 axis positively regulates bone mass, and that GH and IGF-I-IGFBP-3 inversely regulate fat mass, i.e. GH negatively and IGF-I-IGFBP-3 positively regulates it.

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“…GH also stimulates the renal 25-hydroxyvitamin D-1α-hydroxilase activity, enhancing calcium and phosphorus absorption in the gut [4,5]. Moreover, the presence of somatotrophic receptors on the adipocytes membranes in experiments in vitro has revealed a lipolytic action of GH [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Effects of GH-IGF-I excess and gonadal status on bone mineral density and body composition in patients with acromegaly

et al. 2010

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Insulin-like growth factor I (IGF-I) affects plasma lipid profile and inhibits the lipolytic action of growth hormone (GH) in isolated adipocytes

Cited by 15 publications

References 18 publications

Bone metabolism and body composition in Japanese patients with active acromegaly

Bone metabolism and body composition in Japanese patients with active acromegaly

Age-dependent changes in body composition in postmenopausal Japanese women: relationship to growth hormone secretion as well as serum levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3

Effects of GH-IGF-I excess and gonadal status on bone mineral density and body composition in patients with acromegaly

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