Insulin-like growth factor-I, liver function, and hypogonadism in rats with experimentally induced cirrhosis

Castilla‐Cortázar, Inma; Quiroga, Jorge; Prìeto, Jesús

doi:10.1053/jhep.2000.7886

Cited by 12 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…alteration that has been previously described in experimental portal hypertension [18,22]. Also, at 60 days of evolution after clamping of portal vein for 15 min and clamping of portal vein for 5 min in rats, a decrease in the relative weight of the testis for each 100 g of body weight has also been found [19].…”

Section: New Methodologiessupporting

confidence: 63%

Chronic Portal Hypertension in the Rat by Triple-Portal Stenosing Ligation

Diéguez

Aller

Nava

et al. 2002

Journal of Investigative Surgery

View full text Add to dashboard Cite

A surgical technique based on the development of a triple stenosing ligation is used to worsen the complications inherent to the prehepatic chronic portal hypertension. The results have been compared with those obtained in rats with a single-portal stenosing ligation. An increase (p <.05) in the body, liver, spleen, and kidney weights as well as a decrease (p <.001) in the testes weight to body weight ratio were produced in both groups of animals. In addition, the variability in the obtained weights, particularly in the liver weight, stands out. The incidence of portosystemic and portohepatic collateral circulation and of the mesenteric venous vasculopathy increases in the animals with triple-portal stenosing ligation. The new proposed technique is a valid alternative to the classic one that used single portal stenosing ligation.

show abstract

Section: New Methodologiessupporting

confidence: 63%

Chronic Portal Hypertension in the Rat by Triple-Portal Stenosing Ligation

Diéguez

Aller

Nava

et al. 2002

Journal of Investigative Surgery

View full text Add to dashboard Cite

show abstract

“…It is also known that IGF‐I stimulates testosterone synthesis and spermatogenesis [22]. Its deficiency could contribute to the development of hypogonadism associated with cirrhosis, as supported by some experimental data in rats [23].…”

Section: Discussionmentioning

confidence: 97%

Association between serum prostate‐specific antigen level, liver function tests and lipid profile in healthy men

et al. 2008

View full text Add to dashboard Cite

who were aged < 60 years and had serum PSA levels of < 4 ng/mL and serum creatinine levels of < 1.4 mg/dL were enrolled between January 2002 and December 2006. Body weight and height were measured, and levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), ALP, TB, FBS, TC, TG, and HDL, and serum PSA were measured. RESULTSThe mean ( SD ) age of the study population was 44.4 (7.90) years and the mean PSA level 0.89 (0.51) ng/mL. In a univariate analysis there were significant interrelations between serum PSA level and age, BMI, AST, ALT, ALP, TB, HDL and FBS ( P < 0.05). The multiple logistic regression analyses using four percentiles (10th, 25th, 75th, 90th percentile) of serum PSA level showed trends that being older was associated with serum PSA level, and that BMI, ALT, HDL and FBS were negatively correlated with serum PSA level. CONCLUSIONSThese results suggest that serum PSA level was significantly influenced by age, BMI, ALT, HDL and FBS. Further studies are needed to confirm our results and to explain the underlying mechanisms. KEYWORDSprostatic neoplasms, prostate-specific antigen, liver function tests, high-density lipid, cholesterol Study Type -Aetiology (individual cohort study) Level of Evidence 2b

show abstract

“…This further inhibits the synthesis of FSH and LH, and, consequently, the synthesis of testosterone itself [ 74 , 75 ]. Moreover, chronic alcohol intake has been associated with the reduced bioavailability of insulin growth factor (IGF)-1, which physiologically stimulates the synthesis of testosterone [ 76 ]. Finally, it is important to mention that NAD is the cofactor of enzymes involved in both EtOH and androgen metabolism.…”

Section: Alcohol Consumption and Male Infertility: Evidence From Animal And Human Studiesmentioning

confidence: 99%

Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review

Finelli

Mottola

Agarwal

2021

IJERPH

View full text Add to dashboard Cite

Alcohol abuse disorder is a serious condition, implicating more than 15 million people aged 12 years and older in 2019 in the United States. Ethanol (or ethyl alcohol) is mainly oxidized in the liver, resulting in the synthesis of acetaldehyde and acetate, which are toxic and carcinogenic metabolites, as well as in the generation of a reductive cellular environment. Moreover, ethanol can interact with lipids, generating fatty acid ethyl esters and phosphatidylethanol, which interfere with physiological cellular pathways. This narrative review summarizes the impact of excessive alcohol consumption on male fertility by describing its metabolism and how ethanol consumption may induce cellular damage. Furthermore, the impact of alcohol consumption on hormonal regulation, semen quality, and genetic and epigenetic regulations is discussed based on evidence from animal and human studies, focusing on the consequences on the offspring. Finally, the limitations of the current evidence are discussed. Our review highlights the association between chronic alcohol consumption and poor semen quality, mainly due to the development of oxidative stress, as well as its genotoxic impact on hormonal regulation and DNA integrity, affecting the offspring’s health. New landscapes of investigation are proposed for the identification of molecular markers for alcohol-associated infertility, with a focus on advanced OMICS-based approaches applied to the analysis of semen samples.

show abstract

Insulin-like growth factor-I, liver function, and hypogonadism in rats with experimentally induced cirrhosis

Cited by 12 publications

References 7 publications

Chronic Portal Hypertension in the Rat by Triple-Portal Stenosing Ligation

Chronic Portal Hypertension in the Rat by Triple-Portal Stenosing Ligation

Association between serum prostate‐specific antigen level, liver function tests and lipid profile in healthy men

Impact of Alcohol Consumption on Male Fertility Potential: A Narrative Review

Contact Info

Product

Resources

About