2009
DOI: 10.1152/ajpregu.00463.2009
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Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats

Abstract: Van Mieghem T, van Bree R, Van Herck E, Deprest J, Verhaeghe J. Insulin-like growth factor-II regulates maternal hemodynamic adaptation to pregnancy in rats. Am J Physiol Regul Integr Comp Physiol 297: R1615-R1621, 2009. First published September 23, 2009 doi:10.1152/ajpregu.00463.2009.-The relationship between maternal plasma volume (PV) expansion and fetal growth is well established, but the underlying mechanisms remain unclear. Here, we examined the influence of maternal body weight and fetoplacental mass… Show more

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Cited by 16 publications
(22 citation statements)
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“…Protein restriction leads to an expansion of the junctional zone, a decrease in the size of the labyrinth zone, and an increase in the surface area comprising the trophoblast-fetal interface [80]. In contrast, feeding pregnant rats a diet that promotes obesity is associated with decreased placental size, including reductions in both junctional and labyrinth zone volumes [81]. Similarly a high fat diet also decreases the size of the junctional zone but not the placental labyrinth zone [82].…”
Section: The Rat As An Experimental System For Investigating Hemomentioning
confidence: 99%
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“…Protein restriction leads to an expansion of the junctional zone, a decrease in the size of the labyrinth zone, and an increase in the surface area comprising the trophoblast-fetal interface [80]. In contrast, feeding pregnant rats a diet that promotes obesity is associated with decreased placental size, including reductions in both junctional and labyrinth zone volumes [81]. Similarly a high fat diet also decreases the size of the junctional zone but not the placental labyrinth zone [82].…”
Section: The Rat As An Experimental System For Investigating Hemomentioning
confidence: 99%
“…Similarly a high fat diet also decreases the size of the junctional zone but not the placental labyrinth zone [82]. The size of the junctional zone may be positively linked to circulating insulin-like growth factor (IGF) 2 levels [81]. In summary, it appears that within certain limits the developing placenta can respond to nutrient availability by adjusting allocation of trophoblast cells to the junctional zone compartment (uterine-trophoblast interface).…”
Section: The Rat As An Experimental System For Investigating Hemomentioning
confidence: 99%
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“…Maternal IGF-II infusion induces morphological changes in the guinea-pig placenta with Lz expansion and an increased surface area for nutrient transfer, which are not seen with IGF-I treatment near term (Sferruzzi-Perri et al 2006). Furthermore, effects of IGF on placental phenotype may be species specific as IGF-II administration promotes the development of the Jz, not the Lz, in rats (Van Mieghem et al 2009). …”
Section: Insulin-like Growth Factors (Igfs)mentioning
confidence: 99%
“… The changes in maternal circulating concentrations of IGF‐I ( A ) and IGF‐II ( B ) during pregnancy expressed as a percentage of the non‐pregnant state (represented as the dashed line) with respect to the stage of pregnancy The data presented are from the following references: Gargosky et al 1990; Giudice et al 1993; Nason et al 1996; Wallace et al 1997; Sohlstrom et al 1998; Farmer et al 2000; Perry et al 2002; Weber et al 2007; de Boo et al 2008; Van Mieghem et al 2009. …”
Section: Maternal Igf Concentrationsmentioning
confidence: 99%