Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

Λάγιου, Παγώνα; Hsieh, Chung‐Cheng; Lipworth, Loren; Samoli, Evangelia; Okulicz, William C.; Troisi, Rebecca; Xu, Biao; Hall, Per; Ekbom, Anders; Adami, Hans Olov; Trichopoulos, Dimitrios

doi:10.1038/sj.bjc.6605074

Cited by 30 publications

(22 citation statements)

References 31 publications

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“…The hypothesis is supported by the positive association of the cord blood IGF-1 with birth size, which appears to be restricted to daughters of relatively tall mothers [18,35,36]. In contrast to mothers of shorter stature, taller mothers may not impose mechanical constraints on fetal growth, and growth enhancing pregnancy hormones, including IGFs, may therefore be allowed to exercise their effects, and result in a positive association with birth size [34] and subsequently, with breast cancer risk [8,9] in daughters of taller mothers.…”

Section: Discussionmentioning

confidence: 71%

Size at birth and risk of breast cancer: update from a prospective population-based study

et al. 2015

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Birth size variables (birth weight, birth length and head circumference) have been reported to be positively associated with adult breast cancer risk, whereas a possible association of placental weight has not been adequately studied. It has also been suggested that maternal height may modify the association of birth size with adult breast cancer risk, but this has not been studied in detail. We updated a long-term follow-up of 22,931 Norwegian women (average of 51 years of follow up during which 870 women were diagnosed with breast cancer) and assessed placental weight in relation to breast cancer risk, in addition to providing updated analyses on breast cancer risk in relation to birth weight, birth length and head circumference. Placental weight was not associated with risk for breast cancer in adulthood, but there was a positive association of breast cancer risk with birth length (HR 1.13, 95% CI 1.05-1.21, per 2 cm increment), though not with birth weight (HR 1.02, 95% CI 0.95-1.10 per 0.5 kg increment). For birth length, the graded increase in risk was particularly strong among women whose mothers were relatively tall (p for trend, 0.001), compared to the trend among women whose mothers were relatively short (p for trend, 0.221). The results showed a robust and positive association of birth length with breast cancer risk, and may be especially strong in women whose mothers were relatively tall. We found no association of placental weight with risk for breast cancer.

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Section: Discussionmentioning

confidence: 71%

Size at birth and risk of breast cancer: update from a prospective population-based study

et al. 2015

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“…IGF-1 is a hormone that is critically important in growth and development, such that genetic deletion of Igf -1 in mice results in viable pups with lower birth weights [23]. In addition, higher cord blood IGF-1 levels have been positively associated with birth weight [24,25]. Relevant to brain tumors, IGF-1 is required for normal central nervous system development [26], where IGF-1 has been shown to increase malignant glioma cell proliferation in vitro [27].…”

Section: Discussionmentioning

confidence: 99%

Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1

Johnson

Zoellner

Gutmann

2016

Cancer Epidemiology

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Background Individuals with Neurofibromatosis Type 1 (NF1) are strongly predisposed to developing pediatric brain tumors (PBTs), especially optic pathway gliomas (OPGs). Although developmental factors have been implicated in the origins of PBTs in both human and animal studies, associations between early-life factors and PBTs have not been evaluated in individuals with NF1. Our objective was to evaluate associations between peri-gestational characteristics and PBTs in this population. Methods We conducted a cross-sectional study, ascertaining questionnaire and medical record data for 606 individuals <18 years old who enrolled in the NF1 Patient Registry Initiative (NPRI) from 6/9/2011-6/29/2015. One hundred eighty-four individuals had reported PBT diagnoses, including 65 who were identified with OPG diagnoses. Cox proportional hazards regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between PBT and OPG diagnoses and peri-gestational characteristics (prematurity, birth weight, parental age, plurality, family history of NF1, assisted reproductive technology, maternal vitamin supplementation, and parental smoking). Results We observed no significant associations between any of the assessed characteristics and PBTs overall or OPGs with the exception of birth weight. After controlling for potential confounding variables, we observed a significant positive association between birth weight quartile and OPGs with a HR of 3.32 (95% CI 1.39–7.94) for the fourth (≥3915.5 g) compared to the first (≤3020 g) quartile (p for trend = 0.001). Conclusions Consistent with results for PBTs in the general population, these results suggest that higher birth weights increase OPG risk in individuals with NF1.

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“…Racial differences in IGF-1 cord blood concentrations were seen in US whites compared with Chinese neonates [26, 34]; whereas Chinese neonates had higher levels of IGF-2 compared to white neonates. However, others did not find differences in cord IGF-1 concentrations among other racial/ethnic groups in female neonates [21, 24] and a sample of combined female and male neonates [22].…”

Section: Discussionmentioning

confidence: 99%

“…The literature suggests that cord blood IGF-1 concentrations are positively correlated with birth weight and length among taller US white women [34]. Specifically, higher cord IGF-1 and IGFBP-3 concentrations have been correlated with higher birth weight, birth length, head circumference and other anthropometry measures [21, 35–37] whereas lower IGF-1 and IGFBP-3 concentrations are associated with preterm or small for gestational age neonates [37, 38].…”

Section: Discussionmentioning

confidence: 99%

Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates

Agurs‐Collins¹,

Rohrmann

Sutcliffe

et al. 2012

Cancer Causes Control

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Purpose To evaluate whether there is racial variation in venous umbilical cord blood concentrations of sex steroid hormones and the insulin-like growth factor (IGF)-axis between female African-American and white neonates. Methods Maternal and birth characteristics and venous umbilical cord blood samples were collected from 77 African-American and 41 white full-term uncomplicated births at two urban hospitals in 2004 and 2005. Cord blood was measured for testosterone, dehydroespiandrosterone-sulfate (DHEAS), estradiol, sex-steroid hormone binding globulin (SHBG) by immunoassay. IGF-1, IGF-2, and IGF binding protein-3 (IGFBP-3) were measured by ELISA. Crude and multivariable-adjusted geometric mean concentrations were computed for the hormones. Results African-American neonates weighed less at birth (3,228 vs. 3,424 grams, p<0.004) than whites. Birth weight was positively correlated with IGF-1, IGFBP-3 and the molar ratio of IGF1 to IGFBP-3, but inversely correlated with the molar ratio of IGF-2 to IGFBP-3. Adjusted models showed higher testosterone (1.82 vs. 1.47 ng/mL, p=0.006) and the molar ratio of testosterone to SHBG (0.42 vs. 0.30, p=0.03) in African-American compared to white female neonates. IGF-1, IGF-2, and IGFBP-3 were lower in African-American compared to white female neonates, but only the difference for IGF-2 remained significant (496.5 vs. 539.2 ng/mL, p=0.04). Conclusion We provide evidence of racial variation in cord blood testosterone and testosterone to SHBG in African-American compared to white female neonates, and higher IGF-2 in white compared to African-American female neonates. Findings suggest plausible explanations for a prenatal influence on subsequent breast cancer risk and mortality. Further work is needed to confirm these observations.

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Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

Cited by 30 publications

References 31 publications

Size at birth and risk of breast cancer: update from a prospective population-based study

Size at birth and risk of breast cancer: update from a prospective population-based study

Peri-gestational risk factors for pediatric brain tumors in Neurofibromatosis Type 1

Racial variation in umbilical cord blood sex steroid hormones and the insulin-like growth factor axis in African-American and white female neonates

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