Insulin-Like Growth Factor1 Preserves Gastric Pacemaker Cells and Motor Function in Aging via ERK1/2 Activation

Nguyen, Vy Truong Thuy; Taheri, Negar; Choi, Egan L.; Kellogg, Todd A.; Linden, David R.; Hayashi, Yujiro

doi:10.1016/j.jcmgh.2023.06.002

Cited by 3 publications

(4 citation statements)

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“…A study in humans has shown a decrease of approximately 13% in gastric ICC per decade [ 16 ]. Similarly, a decline in gastric ICC has been observed in chronologically aged mice and mice lacking the anti-aging protein α-Klotho ( klotho mice, a progeria model) [ 17 , 18 ]. The age-related decline in ICC is correlated with gastric dysfunction, specifically impaired fundic relaxation and decreased gastric compliance, rather than delayed gastric emptying [ 17 , 18 , 19 ].…”

Section: Agingmentioning

confidence: 99%

“…Similarly, a decline in gastric ICC has been observed in chronologically aged mice and mice lacking the anti-aging protein α-Klotho ( klotho mice, a progeria model) [ 17 , 18 ]. The age-related decline in ICC is correlated with gastric dysfunction, specifically impaired fundic relaxation and decreased gastric compliance, rather than delayed gastric emptying [ 17 , 18 , 19 ]. These changes occur without any loss of enteric neurons in the stomachs of progeric klotho mice [ 18 ].…”

Section: Agingmentioning

confidence: 99%

“…These changes occur without any loss of enteric neurons in the stomachs of progeric klotho mice [ 18 ]. The age-associated decline in ICC stem cells or progenitors (ICC-SC) plays a significant role in the loss of ICC and the associated gastric dysfunctions [ 17 ]. The decline in ICC-SC with age is linked to the suppression of the extracellular signal-regulated kinase (ERK)1/2 signaling pathway.…”

Section: Agingmentioning

confidence: 99%

“…The decline in ICC-SC with age is linked to the suppression of the extracellular signal-regulated kinase (ERK)1/2 signaling pathway. Reduced cyclin D1 (CCND1) and increased cyclin-dependent kinase inhibitor 2B (CDKN1B, also known as p27 Kip 1 ) downregulate the proliferation and self-renewal of ICC-SC by interfering with entry into the cell cycle [ 17 ]. Recently, activation of ERK signaling by the nutrient-sensing hormone insulin-like growth factor 1 (IGF1) has been shown to mitigate age-related reductions in ERK phosphorylation, the loss of ICC/ICC-SC, impaired gastric compliance, and reduced food intake [ 18 ].…”

Section: Agingmentioning

confidence: 99%

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The Crucial Role of the Interstitial Cells of Cajal in Neurointestinal Diseases

Choi,

Taheri,

Tan

et al. 2023

Biomolecules

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Neurointestinal diseases result from dysregulated interactions between the nervous system and the gastrointestinal (GI) tract, leading to conditions such as Hirschsprung’s disease and irritable bowel syndrome. These disorders affect many people, significantly diminishing their quality of life and overall health. Central to GI motility are the interstitial cells of Cajal (ICC), which play a key role in muscle contractions and neuromuscular transmission. This review highlights the role of ICC in neurointestinal diseases, revealing their association with various GI ailments. Understanding the functions of the ICC could lead to innovative perspectives on the modulation of GI motility and introduce new therapeutic paradigms. These insights have the potential to enhance efforts to combat neurointestinal diseases and may lead to interventions that could alleviate or even reverse these conditions.

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