Insulin-Like Growth Factors and the Developing and Mature Rat Small Intestine: Receptors and Biological Actions

Young, Graeme P.; Taranto, Tina; Jonas, Helen A.; Cox, Alison; Hogg, Annette; Werther, George A.

doi:10.1159/000200392

Cited by 109 publications

(67 citation statements)

References 24 publications

(28 reference statements)

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“…It stimulates gut epithelial cell proliferation (Chen et al 1991, Steeb et al 1994 and increases gut weight in rats after dexamethasone treatment or partial gut resection . It may also accelerate maturation of gut permeability (McRoberts & Riley 1992) and brush border enzyme maturation in neonatal rats (Young et al 1990, Ma & Xu 1997. Consistent with these findings, we found that IGF-I infusion increased wall thickness in all regions of the gut studied.…”

Section: Discussionsupporting

confidence: 89%

Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep

Kimble¹,

Breier²,

Gluckman³

et al. 1999

Journal of Endocrinology

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Infants with upper gut atresia often have impaired intrauterine growth and gut function. IGF-I is important in fetal growth and is contained in amniotic fluid. We therefore wanted to test the hypothesis that IGF-I infused into fetal gut would reverse the effects of an upper gut obstruction on gut structure and growth in fetal sheep.At 90 days gestation fetuses (n=6 per group) underwent oesophageal ligation, followed by continuous infusion of IGF-I (1-8 µg/day) or saline into the gut beyond the ligation until 137 days. Controls underwent sham ligation only. Oesophageal ligation tended to reduce fetal body and organ weights. IGF-I treatment prevented this reduction and increased body length and spleen weight above those of controls. The decrease in bowel wall thickness induced by oesophageal ligation was also prevented by IGF-I treatment. Amniotic fluid IGF-I concentrations did not change over gestation and were higher in the IGF-I treated group. No change in fetal plasma IGF-I concentrations were detectable. We conclude that enterally administered IGF-I may enhance fetal growth and gut development in utero and that IGF-I in amniotic fluid may play a physiological role in gut development in the fetus.

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Section: Discussionsupporting

confidence: 89%

Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep

Kimble¹,

Breier²,

Gluckman³

et al. 1999

Journal of Endocrinology

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“…In agreement with other studies (Young et al 1990, Heinz-Erian et al 1991, MacDonald 1999, binding capacities of IGF-IIR were consistently higher than those of IGF-IR and IR. As B max values were highest and mRNA expression values were lowest for IGF-IIR, the ratios of B max /mRNA were much higher in IGF-IIR than in IGF-IR and IR.…”

Section: Comparisons and Associations Between Mrna Levels And B Max Osupporting

confidence: 92%

“…Studies on site-specific and on postnatal variations of intestinal IGF-IR, IGF-IIR and IR have been reported in pigs, rabbits and rats (Schober et al 1990, Young et al 1990, Nowak et al 1996, Staley et al 1998. Differences in IGF and insulin receptor numbers at different intestinal sites as found in our calves have been reported in rats (Heinz-Erian et al 1991, Buts et al 1997, FernandezMoreno et al 1997 and are consistent with our previous studies in calves (Baumrucker et al 1994).…”

Section: Igf-ir Igf-iir and Ir Concentrations At The Mrna And Proteimentioning

confidence: 99%

Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves

Georgiev¹,

Georgieva²,

Pfaffl³

et al. 2003

Journal of Endocrinology

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Intestinal development is modified by age and nutrition, mediated in part by insulin-like growth factors (IGF-I, IGF-II) and insulin. We have investigated whether expression of IGF-I, IGF-II and insulin receptors (IGF-IR, IGF-IIR and IR; measured by real-time RT-PCR) and binding capacity (B max ) of IGF-IR, IGF-IIR and IR in the mucosa of the small and large intestine of neonatal calves are modified by age and different feeding regimes.In experiment 1, pre-term (GrP) and full-term (GrN) calves (after 277 and 290 days of pregnancy respectively) were killed immediately after birth before being fed; a further group of full-term calves were fed for 7 days and killed on day 8 of life (GrC 1-3 ). In experiment 2, full-term calves were killed on day 8 after being fed first-colostrum for 7 days (GrC max

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“…In the orally lGF-I-treated rats, the jejunal brush border enzyme activities of maltase, lactase, alkaline phosphatase, and amino peptidase were increasedby 20,20, 50, and 2O%, rcspectively, over the controls (Young et al 1990). Young^-et al (1990) which is synchronized with the highest prevalence of gut-epithelium brush border IGF receptors (Young et al 1990) and rapid gut development in the suckling neonate. Therefore, it could be considered an oversight for Juskevich and Guyer (1990) to suggest that ingested IGF{ is inactive.…”

Section: Bioreactivity Of Milk and Milk Products From Growth' Hormonementioning

confidence: 86%

“…However, Young et al (1990) have shown in suckling rat pups that oral doses of IGF-I atl pg d-l for 6 d [3 orders of magnitude lower than the orally inactive limit for IGF-I stated by Juskevich and Guyer (1990) I were active in the stimulation ofjejunal brush border enzymes, but not in intestinal growth. In the orally lGF-I-treated rats, the jejunal brush border enzyme activities of maltase, lactase, alkaline phosphatase, and amino peptidase were increasedby 20,20, 50, and 2O%, rcspectively, over the controls (Young et al 1990). Young^-et al (1990) which is synchronized with the highest prevalence of gut-epithelium brush border IGF receptors (Young et al 1990) and rapid gut development in the suckling neonate.…”

Section: Bioreactivity Of Milk and Milk Products From Growth' Hormonementioning

confidence: 96%

A review of bovine growth hormone

Burton¹,

McBride²,

Block³

et al. 1994

Can. J. Anim. Sci.

132

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. 74: 16'7-201. Unprecedented numbers of technical papers, abstracts, and short communications have been published in the past decade regarding the effects of exogenous bovine growth hormone on milk production, health, and reproductive efficiency of treated dairy cows. In well-managed dairy herds, exogenous growth hormone increases milk production without altering normal variability in milk composition. This has held true regardless of dairy breed tested, geographical location studied, or feeding management system used. Also consistent across studies is the rapidity of the galactopoietic effect of administered bovine growth hormone, which arises from altered partitioning and use of post-absorptive nutrients and increased synthetic capacity of the mammary gland. Growth hormone and its associated peptide, insulin-like growth factor-I, are now known to provide chronic lipolytic, diabetogenic, and gluconeogenic signals to target tissues culminating in increased mammary gland availability of glucose and nonesterified fatty acids. Together with yet ill-defined effects on mammary secretory tissue, this homeorhetic control of metabolism elicited by exogenous growth hormone is so efficient that treated cows are not more susceptible to metabolic disorders than untreated cows. However, some studies have reported an increased frequency of mastitis in groups of treated cows. This has been attributed mainly to increased milk volume in the mammary glands of treated cows and no convincing data are available that show decreased mammary gland immunity as a result of growth hormone treatments. On the contrary, an expanding body of evidence implicates growth hormone as a key neuroendocrine factor that is required for immunological competence. Trends of decreased reproductive efficiency in cows treated with growth hormone have also been reported, but available data imply that this is probably an indirect effect via prolonged negative energy balance in cows treated in early lactation rather than a direct negative effect on estrous cycling via altered reproductive hormone profiles. The objectives of the present review are to bring into focus and summarize pertinent biological discoveries regarding the treatment of dairy cows with recombinant bovine growth hormone, and to explore areas where additional growth hormone research is needed or warranted.Key words: Growth hormone, somatotropin, dairy cows, insulin-like growth factor-I Burton, J. L., McBride, B. W., Block, E., Glimm, D. et Kennelly,E. 1994. L'horrnone de croissance bovinemais au point bibliographique. Can. J. Anim. Sci. 74: . D'innombrables m6moires techniques, r6sum6s analytiques et communications brdves ont 6t6 publi6s dans la dernidre d6cennie au sujet des effets de I'hormone de croissance bovine exogdne sur la production laitidre, sur la sant6 et sur les fonctions de reproduction des vaches laitidres trait6es. Dans les 6levages laitiers bien conduits, la GH exogbne accroit la production de lait sans modifier la variabilit6 normale de sa composition, et cela inddpendamme...

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Insulin-Like Growth Factors and the Developing and Mature Rat Small Intestine: Receptors and Biological Actions

Cited by 109 publications

References 24 publications

Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep

Enteral IGF-I enhances fetal growth and gastrointestinal development in oesophageal ligated fetal sheep

Insulin-like growth factor and insulin receptors in intestinal mucosa of neonatal calves

A review of bovine growth hormone

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