Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Frantsiyants, Elena M.; Бандовкина, В. А.; Kaplieva, Irina V.; Surikova, Ekaterina I.; Pogorelova, Yulia A.; Pogorelova, Yu. A.; Trepitaki, Lidia K.; Cheryarina, Natalia D.; Kotieva, I. M.; Morozova, M. I.

doi:10.20538/1682-0363-2022-3-112-119

Bûll. sib. med.

2022

DOI: 10.20538/1682-0363-2022-3-112-119

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Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Elena M. Frantsiyants¹,

В. А. Бандовкина²,

Irina V. Kaplieva³

et al.

Abstract: Persistent hyperglycemia resulting from diabetes mellitus causes microvascular lesions and long-term diabetic complications, such as nephropathy.The aim of the study was to analyze the levels of insulin-like growth factors (IGFs), their carrier proteins (IGFBP), and markers of kidney tissue damage (IL-18, L-FABP, cystatin C, NGAL, and KIM-1) in male rats with diabetes mellitus, tumor growth, and their combination.Materials and methods. The study included white outbred male rats (n = 32) weighing 180–220 g. The… Show more

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Insulin-like growth factors and their transfer protein in the blood of patients with primary and recurrent soft tissue sarcomas

Goroshinskaya

Kaplieva

Sagatelyan

et al. 2022

jour

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Introduction. Soft tissue sarcomas (STS) are rare diseases but their characteristic tendency for recurrence and high mortality dictate the need for the search for prognostic biomarkers for identification of patients with the risk of recurrence. In this context, the system of insulin-like growth factors (IGF) and their insulin-like growth factor-binding proteins (IGFBP) is of interest because it was shown that disruption of the IGF system regulation leads to cancer cell proliferation and migration and chemotherapy resistance.The study objective is to investigate the levels of the IGF system components in blood of patients with primary and recurrent STS.Materials and methods. In total, 54 patients with STS, T2bN0M0, were examined: 12 men and 12 women with primary STS, 10 men and 20 women with recurrent STS, as well as healthy donors (10 men and 10 women). Mean patient age was 63.1 ± 0.9 years. In blood sampled prior to treatment, the levels of insulin-like growth factor 1 (IGF1), insulin-like growth factor 2 (IGF2) and insulin-like growth factor-binding protein 2 (IGFBP2) were measured by ELISA using Mediagnost kits (Germany). Statistical analysis was performed using Statistica 10 software and non-parametric Mann-Whitney test.Results. In primary STS, the levels of IGF1 in men with G3–4 tumors and all women decreased 14- and 20-fold, respectively, compared to healthy donors. Additionally, an insignificant decrease of IGF2 level in men and a decrease of IGF1/IGF2 ratio by the factor of 8.8 in men with G3–4 tumors and by the factor of 24.3 in women were observed. In recurrences, IGF1 level decreased by 40 % in men and by 78–85.5 % in women, while IGF2 level in men with G3–4 tumors decreased by 19 %, in women increased by 21–58 % compared to donors. In women with primary STS and recurrences of G3–4 tumors, IGFBP2 was also elevated. In men with G3–4 tumors, changes in IGFBP2 levels were less significant and had an opposite trend compared to women.Conclusion. STS recurrence is accompanied by imbalance of IGF system components in blood, especially in patients of both sexes with G3–4 tumors. Correlation between increased IGFBP2 level in STS and clinical characteristics of the disease, especially in recurrence, suggest prognostic significance of this molecule.

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Insulin-like growth factors and their transfer protein in the blood of patients with primary and recurrent soft tissue sarcomas

Goroshinskaya

Kaplieva

Sagatelyan

et al. 2022

jour

Self Cite

View full text Add to dashboard Cite

show abstract

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Insulin-like growth factors and their carrier proteins in kidneys of rats with experimental diabetes, malignant tumor, and their combination

Cited by 1 publication

References 26 publications

Insulin-like growth factors and their transfer protein in the blood of patients with primary and recurrent soft tissue sarcomas

Insulin-like growth factors and their transfer protein in the blood of patients with primary and recurrent soft tissue sarcomas

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