Insulin-Like Growth Factors, Insulin-Like Growth Factor-Binding Proteins, and Endometrial Cancer in Postmenopausal Women: Results from a U.S. Case-Control Study

Abstract

Objective: To assess whether circulating insulin-like growth factor-1 (IGF-1), IGF-2, insulin-like growth factor-binding protein-1 (IGFBP-1), or IGFBP-3 were associated with endometrial cancer in postmenopausal women. Study Design: Between 1987 and 1990, we conducted a case-control study of 405 women with endometrial cancer and 297 matched population-based controls. This analysis included 174 postmenopausal cases and 136 controls. Results: In logistic regression models adjusted for potential confounders, higher IGF-1 levels were not positively associated with endometrial cancer: odds ratio (OR) for the highest tertile versus the lowest tertile = 0.63, 95% confidence interval (CI) = 0.30–1.32. Endometrial cancer was inversely associated with IGF-2 (OR for the highest tertile = 0.35, 95% CI = 0.18–0.69) and IGFBP-3 (OR for the highest tertile = 0.40, 95% CI = 0.21–0.77), and not associated with IGFBP-1. Conclusion: Serum IGF-1, IGF-2, and IGFBP-3, but not IGFBP-1, were inversely associated with endometrial cancer in postmenopausal women. These associations and the potential role of the IGF system in endometrial proliferation and carcinogenesis warrant further research.

The Histone Methyltransferase SETD8 Regulates the Expression of Tumor Suppressor Genes via H4K20 Methylation and the p53 Signaling Pathway in Endometrial Cancer Cells

“…Furthermore, pathway analysis showed that genes significantly altered by SETD8 are involved in several pathways such as the p53 signaling pathway, MAPK signaling pathway, and uptake by IGFBPs. IGFBPs and related proteins are associated with endometrial cancer and may represent a risk factor, supporting our data [ 41 , 42 ]. Additionally, gene ontology analysis indicated that the genes involved in cellular proliferation, angiogenesis, and infection were highly interconnected with p53 in SETD8 knockdown in endometrial cell lines.…”

Multiple databases analyzed the prognosis prediction of renin secretion pathway-related genes in renal clear cell carcinoma and immunotherapy

“…IGFBP3 regulates IGF1 activity by binding to IGF1 and IGFBP3 leads to the recurrence and metastasis of lung cancer ( 14 ). High IGFBP3 expression has been observed in endometrial cancer, stomach cancer, and advanced prostate cancer ( 15 - 17 ) and increases the risk of premenopausal breast and prostate cancers ( 17 , 18 ). Transcription factor 7 like 2 (TCF7L2) is a key regulator of cell development and growth ( 19 , 20 ) and is associated with malignant tumours such as colon cancer and prostate cancer ( 21 , 22 ).…”

Association between IGFBP1 expression and cancer risk: A systematic review and meta-analysis

“…What is more, several studies showed that the results of IGFBP1 expression correlated with risk of cancer were opposite or insignificant [ [14] , [15] , [16] , [17] ], and none of these meta-analyses explored the relationship between IGFBP1 expression and breast cancer and endometrial cancer. To address these issues, we aimed to combine all available evidence to further comprehensively judge the relationship between IGFBP1 expression and various cancers risk in the present meta-analysis [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] ].…”