Insulin Lispro Lowers Postprandial Glucose in Prepubertal  Children With Diabetes

Deeb, Larry C.; Holcombe, John H.; Brunelle, Rocco L.; Zalani, Sunita; Brink, Stuart; Jenner, M.; Kitson, Hilary; Perlman, Kusiel; Spencer, Martha L.

doi:10.1542/peds.108.5.1175

Cited by 74 publications

(86 citation statements)

References 13 publications

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“…A further 15 studies were excluded from this analysis. Of these, five were performed with patients with type 2 diabetes [23,24,25,26,27], three were performed with children [28,29,30], one with adolescents [31], one with children and adults [32], one with pregnant type 1 diabetic patients [33], two with patients with gestational diabetes [34,35] and two duplicate publications did not provide further information on prespecified outcome measures [36,37]. We ultimately identified 27 randomised controlled trials that compared SAI analogues with regular insulin using either CSII or IIT as injection regimens.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis of short-acting insulin analogues in adult patients with type 1 diabetes: continuous subcutaneous insulin infusion versus injection therapy

Siebenhofer¹,

Plank²,

Berghold

et al. 2004

Diabetologia

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Aims/hypothesis. This study aimed to compare the effect of treatment with short-acting insulin (SAI) analogues versus structurally unchanged short-acting insulin (regular insulin) on glycaemic control and on the risk of hypoglycaemic episodes in type 1 diabetic patients using different insulin treatment strategies. Methods. We performed a meta-analysis of 27 randomised controlled trials that compared the effect of SAI analogues with regular insulin in patients with type 1 diabetes mellitus. The treatments were administered either via continuous subcutaneous insulin infusion (CSII) or by conventional intensified insulin therapy (IIT) with short-acting insulin injections before meals and basal insulin administered once or twice daily in most cases. Results. HbA 1 c levels were reported for 20 studies. For studies using CSII, the weighted mean difference between values obtained using SAI analogues and regular insulin was −0.19% (95% CI: −0.27 to − 0.12), whereas the corresponding value for injection studies was −0.08% (95% CI: −0.15 to −0.02). For the analysis of overall hypoglycaemia, we used the results from nine studies that reported the mean frequency of hypoglycaemic episodes per patient per month. For studies using CSII, the standardised mean difference between SAI analogues and regular insulin was −0.07 (95% CI: −0.43 to 0.28), whereas for IIT studies the corresponding value was −0.04 (95% CI: −0.24 to 0.16). Conclusions/interpretation. Taking into consideration the low quality of the trials included, we can conclude that use of a short-acting insulin analogue in CSII therapy provides a small, but statistically significant improvement in glycaemic control compared with regular insulin. An even smaller effect was obtained with the use of ITT. The rate of overall hypoglycaemic episodes was not significantly reduced with short-acting insulin analogues in either injection regimen.

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Section: Resultsmentioning

confidence: 99%

Meta-analysis of short-acting insulin analogues in adult patients with type 1 diabetes: continuous subcutaneous insulin infusion versus injection therapy

Siebenhofer¹,

Plank²,

Berghold

et al. 2004

Diabetologia

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“…The number of patients in each study ranged from 7 to 1008. Of the 48 crossover studies, 19,20,24,25,30,32,33,35,[37][38][39][42][43][44][45]47,48,51,55,56,58,[62][63][64][65][66][67][69][70][71][72][73][74]78,79,[81][82][83]85,87,89,93,96,[100][101][102]121 most lacked or did not mention a washout period. All studies were of open-label design.…”

Section: Study Characteristics and Methodologic Qualitymentioning

confidence: 99%

Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis

Singh

Ahmad²,

Lal³

et al. 2009

Canadian Medical Association Journal

222

154

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“…Dosing with lispro after meals allows a care provider to more accurately titrate the insulin doses for an erratic eater, with the goal of matching actual food intake and insulin more closely and minimizing the potential for hypoglycemia. Other studies have shown that in the child with more predictable eating habits, premeal insulin dosing results in lower postprandial blood glucose values (65).…”

Section: Basal Bolus Insulin Regimensmentioning

confidence: 97%

Care of Children and Adolescents With Type 1 Diabetes

Klingensmith²,

et al. 2005

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Insulin Lispro Lowers Postprandial Glucose in Prepubertal Children With Diabetes

Cited by 74 publications

References 13 publications

Meta-analysis of short-acting insulin analogues in adult patients with type 1 diabetes: continuous subcutaneous insulin infusion versus injection therapy

Meta-analysis of short-acting insulin analogues in adult patients with type 1 diabetes: continuous subcutaneous insulin infusion versus injection therapy

Efficacy and safety of insulin analogues for the management of diabetes mellitus: a meta-analysis

Care of Children and Adolescents With Type 1 Diabetes

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