Insulin-loaded nanoparticles based on acetylated cashew gum/chitosan complexes for oral administration and diabetes treatment

Silva, Eliadna de Lemos Vasconcelos; Oliveira, Antônia Carla de Jesus; Moreira, Lívia Maria Coelho de Carvalho; Silva-Filho, Edson C.; Wanderley, Almir Gonçalves; Soares, Mônica Felts de La Roca; Soares-Sobrinho, José Lamartine

doi:10.1016/j.ijbiomac.2023.124737

Cited by 7 publications

(3 citation statements)

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“…The interactions between mucin and particle surface are highly influenced by the acidic pH of the gastrointestinal tract with enhanced cross-linkages Amine and carboxyl groups promote mucoadhesion whereas PEGylation produces a brush-like conformation that prevents mucin-particle interaction thereby promoting mucopenetration. Other modifications such as acetylation of natural polysaccharides have also been shown to improve interactions of the particles with mucin . Under acidic conditions, protonation of the mucin carboxyls masks electrostatic interactions but exposes hydrophobic domains.…”

Section: Hybrid Mechanisms Of Oral Insulin Formulationsmentioning

confidence: 99%

“…Using the polyelectrolyte complexation method, acetylated cashew gum and chitosan were combined to encapsulate insulin to obtain reduced blood glucose levels in vivo for up to 12 h postadministration. 28 Chitosan derivative made with cholic acid, quaternary ammonium, and hydroxypropyl methylcellulose phthalate (HPMCP) protected the loaded insulin from further degradation in the GI tract, with HPMCP increasing the mucoadhesion of the nanoparticle in the ileum. Moreover, the colic acid groups significantly improved the absorption of the nanoparticles in the ileum and liver.…”

Section: Mucoadhesive (Ma) Formulations For Insulinmentioning

confidence: 99%

“…Other modifications such as acetylation of natural polysaccharides have also been shown to improve interactions of the particles with mucin. 28 Under acidic conditions, protonation of the mucin carboxyls masks electrostatic interactions but exposes hydrophobic domains. PEGylation and amine groups provide the penetration property.…”

Section: Hybrid Mechanisms Of Oral Insulin Formulationsmentioning

confidence: 99%

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Muco-Adhesive and Muco-Penetrative Formulations for the Oral Delivery of Insulin

Paul,

Bhuyan,

Balasoupramanien

et al. 2024

ACS Omega

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Insulin, a pivotal anabolic hormone, regulates glucose homeostasis by facilitating the conversion of blood glucose to energy or storage. Dysfunction in insulin activity, often associated with pancreatic β cells impairment, leads to hyperglycemia, a hallmark of diabetes. Type 1 diabetes (T1D) results from autoimmune destruction of β cells, while type 2 diabetes (T2D) stems from genetic, environmental, and lifestyle factors causing β cell dysfunction and insulin resistance. Currently, insulin therapy is used for most of the cases of T1D, while it is used only in a few persistent cases of T2D, often supplemented with dietary and lifestyle changes. The key challenge in oral insulin delivery lies in overcoming gastrointestinal (GI) barriers, including enzymatic degradation, low permeability, food interactions, low bioavailability, and long-term safety concerns. The muco-adhesive (MA) and muco-penetrative (MP) formulations aim to enhance oral insulin delivery by addressing these challenges. The mucus layer, a hydrogel matrix covering epithelial cells in the GI tract, poses significant barriers to oral insulin absorption. Its structure, composition, and turnover rate influence interactions with insulin and other drug carriers. Some of the few factors that influence mucoadhesion and mucopenetration are particle size, surface charge distribution, and surface modifications. This review discusses the challenges associated with oral insulin delivery, explores the properties of mucus, and evaluates the strategies for achieving excellent MA and MP formulations, focusing on nanotechnologybased approaches. The development of effective oral insulin formulations holds the potential to revolutionize diabetes management, providing patients with a more convenient and patient-friendly alternative to traditional insulin administration methods.

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Section: Hybrid Mechanisms Of Oral Insulin Formulationsmentioning

confidence: 99%

Section: Mucoadhesive (Ma) Formulations For Insulinmentioning

confidence: 99%

Section: Hybrid Mechanisms Of Oral Insulin Formulationsmentioning

confidence: 99%

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