Insulin receptor signaling for the proliferation of pancreatic β-cells: Involvement of Ca<sup>2+</sup>second messengers, IP<sub>3</sub>, NAADP and cADPR

Shawl, Asif Iqbal; Park, Kwang‐Hyun; Kim, Uh-Hyun

doi:10.4161/isl.1.3.9646

Cited by 28 publications

(24 citation statements)

References 19 publications

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“…That the mechanisms for NAADP uptake and release are present only in the glucose metabolism-related cells, adipocytes, and pancreatic islets but not the acinar cells suggests that NAADP could be utilized specifically and selectively for glucose homeostasis. Indeed, we and others have shown previously that NAADP is the Ca 2ϩ messenger responsible for mediating the autocrine effects of insulin in islets (36) and ␤-cells (13). These data, together with our current demonstration of its release from these cells and its activity of stimulation of insulin secretion, further document its physiological role in amplifying the insulin signals.…”

Section: Discussionsupporting

confidence: 56%

“…Cyclic ADP-ribose is formed by the cyclization of NAD, whereas NAADP is synthesized by a base exchange reaction that replaces the nicotinamide group of NADP with nicotinic acid (6 -9). The base exchange reaction for NAADP synthesis requires acidic pH (10), consistent with NAADP targeting the lysosome-like acidic organelles (3,(11)(12)(13).…”

Section: Nicotinic Acid Adenine Dinucleotide Phosphate (Naadp)mentioning

confidence: 99%

“…6C). We and others have observed that treatment of pancreatic islets or ␤-cells with insulin can stimulate insulin production, resulting in an increase in cellular insulin content (13,36). Immunochemistry staining revealed that the NAADP treatment increases the number of insulin-positive islets as compared with those of the control group (Fig.…”

Section: Administration Of Naadp Ameliorates Glucose Tolerance Insulmentioning

confidence: 99%

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Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

Park

Kim

Shawl

et al. 2013

Journal of Biological Chemistry

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Background: External application of a Ca 2ϩ -mobilizing messenger, NAADP, to ␤-cells activates intracellular Ca 2ϩ changes and stimulates insulin secretion. Results: NAADP is transported into adipocytes and ␤-cells in a glucose-dependent manner and is also released from pancreatic islets upon stimulation by high glucose. Conclusion: NAADP functions in an auto-/paracrine manner to regulate glucose homeostasis. Significance: NAADP can be exploited as a potential antidiabetic agent.

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Section: Discussionsupporting

confidence: 56%

Section: Nicotinic Acid Adenine Dinucleotide Phosphate (Naadp)mentioning

confidence: 99%

Section: Administration Of Naadp Ameliorates Glucose Tolerance Insulmentioning

confidence: 99%

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Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

Park

Kim

Shawl

et al. 2013

Journal of Biological Chemistry

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“…However, cGMP-independent cADPR synthesis had also been found in the eggs [130]. In mammalian cells, both cGMP- [110,[131][132][133] and cAMP-dependent [134][135][136][137] cADPR-synthesis have been reported. Likewise, in lymphokine-activated killer cells, NAADP synthesis is stimulated by both cAMP and cGMP [110].…”

Section: Membrane Topology and Regulation Of Cd38mentioning

confidence: 99%

Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling

Lee

2011

Sci. China Life Sci.

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The concept advanced by Berridge and colleagues that intracellular Ca 2+ -stores can be mobilized in an agonist-dependent and messenger (IP 3 )-mediated manner has put Ca 2+ -mobilization at the center stage of signal transduction mechanisms. During the late 1980s, we showed that Ca 2+ -stores can be mobilized by two other messengers unrelated to inositol trisphosphate (IP 3 ) and identified them as cyclic ADP-ribose (cADPR), a novel cyclic nucleotide from NAD, and nicotinic acid adenine dinucleotide phosphate (NAADP), a linear metabolite of NADP. Their messenger functions have now been documented in a wide range of systems spanning three biological kingdoms. Accumulated evidence indicates that the target of cADPR is the ryanodine receptor in the sarco/endoplasmic reticulum, while that of NAADP is the two pore channel in endolysosomes.As cADPR and NAADP are structurally and functionally distinct, it is remarkable that they are synthesized by the same enzyme. They are thus fraternal twin messengers. We first identified the Aplysia ADP-ribosyl cyclase as one such enzyme and, through homology, found its mammalian homolog, CD38. Gene knockout in mice confirms the important roles of CD38 in diverse physiological functions from insulin secretion, susceptibility to bacterial infection, to social behavior of mice through modulating neuronal oxytocin secretion. We have elucidated the catalytic mechanisms of the Aplysia cyclase and CD38 to atomic resolution by crystallography and site-directed mutagenesis. This article gives a historical account of the cADPR/NAADP/CD38-signaling pathway and describes current efforts in elucidating the structure and function of its components.cyclic ADP-ribose, cADPR, NAADP, nicotinic acid adenine dinucleotide phosphate, CD38, ADP-ribosyl cyclase, Calcium mobilization and signaling Citation:Lee H C. Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling. Sci China Life Sci, 2011Sci, , 54: 699 -711, doi: 10.1007 In 1983, Berridge and colleagues published a study showing that agonists, such as carbachol, can activate Ca 2+ release from non-mitochondrial Ca 2+ stores and the effect is mediated by a Ca 2+ messenger, inositol 1,4,5-trisphosphate (IP 3 ) [1]. The targeted Ca 2+ stores were later identified as the endoplasmic reticulum (ER), which has since been shown to be the major intracellular Ca 2+ stores. This seminal study ushered in the current field of Ca 2+ signaling as we know it and has made the field center stage. IP 3 is derived from a phospholipid, phosphatidyl inositol 4,5-bisphosphate, present on the cytoplasmic side of the plasma membrane. Agonist binding to its specific receptor leads to activation of phospholipase C and the hydrolysis of the phospholipid, releasing the head group that is IP 3 . The structure of IP 3 is shown in Figure 1. It has three phosphates on the inositol ring. Both the number of phosphates and the position of the phosphates are critical to the binding of IP 3 to its receptor in the ER. The space-filling model of IP 3 shown in Figu...

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“…Ins(1,4,5)P 3 is produced by activated phospholipase C (PLC), whereas cADPR and NAADP are produced by ADP-ribosyl cyclase (ADPRcyclase). [7][8][9] Although CD38 has been known as a mammalian prototype of ADPR-cyclase, some studies of tissues from CD38 knockout mice show equal or higher levels of NAADP as compared with wild-type tissues. 10 We have also shown…”

Section: Introductionmentioning

confidence: 99%

Involvement of actin filament in the generation of Ca²⁺mobilizing messengers in glucose-induced Ca²⁺signaling in pancreatic β-cells

Shawl

Park

Kim

et al. 2012

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Insulin receptor signaling for the proliferation of pancreatic β-cells: Involvement of Ca²⁺second messengers, IP₃, NAADP and cADPR

Cited by 28 publications

References 19 publications

Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling

Involvement of actin filament in the generation of Ca²⁺mobilizing messengers in glucose-induced Ca²⁺signaling in pancreatic β-cells

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Insulin receptor signaling for the proliferation of pancreatic β-cells: Involvement of Ca2+second messengers, IP3, NAADP and cADPR

Cited by 28 publications

References 19 publications

Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

Autocrine/Paracrine Function of Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) for Glucose Homeostasis in Pancreatic β-Cells and Adipocytes

Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling

Involvement of actin filament in the generation of Ca2+mobilizing messengers in glucose-induced Ca2+signaling in pancreatic β-cells

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Insulin receptor signaling for the proliferation of pancreatic β-cells: Involvement of Ca²⁺second messengers, IP₃, NAADP and cADPR

Involvement of actin filament in the generation of Ca²⁺mobilizing messengers in glucose-induced Ca²⁺signaling in pancreatic β-cells