Insulin Receptor Signaling in Health and Disease

Baghaie, Leili; Bunsick, David A.; Szewczuk, Myron R.

doi:10.3390/biom13050807

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Another significant factor in the initiation of diabetes and post-COVID-19 hypertension is the activation of signaling pathways, such as the Insulin Signaling Pathway and the Oxidative Stress Pathway, 24,25 which play a crucial role in the development of insulin resistance, vascular dysfunction, and endothelial damage ultimately leading to hypertension. 26 In our study, we substantiated these pathways by referencing KEGG 10 as a point of reference.…”

Section: Discussionmentioning

confidence: 99%

A Network Analysis of Molecular Interactions to Study the Development of New-onset Diabetes and Hypertension after COVID-19 Infection Using Bioinformatics Tools

de Oliveira Andrade,

de Oliveira,

de Oliveira

et al. 2023

Preprint

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IntroductionThe association between COVID-19 infection and the development of new-onset diabetes and hypertension is an emerging area of research. However, a comprehensive understanding of the underlying molecular mechanisms is still lacking. Network analysis using bioinformatics tools can provide valuable insights into the complex molecular interactions involved in these conditions after COVID-19 infection.ObjectiveThis study aims to use bioinformatics tools to analyze the network of molecular interactions related to new-onset diabetes and hypertension following COVID-19 infection.MethodsData from publicly available databases were utilized, including gene expression profiles and protein-protein interaction information. Differential expression analysis was performed to identify genes that were differentially expressed in individuals with new-onset diabetes and hypertension after COVID-19 infection compared to healthy controls. A protein interaction network was constructed using bioinformatics tools to explore the functional relationships among the identified differentially expressed genes.ResultsThe network analysis revealed several key proteins and pathways related to the pathogenesis of new-onset diabetes and hypertension after COVID-19 infection. Notably, proteins involved in insulin signaling, glucose metabolism, inflammation, and blood pressure regulation were found to be prominently associated. The signaling pathway and the renin-angiotensin system were identified as key pathways in this context.ConclusionThis study provides insights by showing a network-based perspective on the molecular interactions involved in the development of new-onset diabetes and hypertension after COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

A Network Analysis of Molecular Interactions to Study the Development of New-onset Diabetes and Hypertension after COVID-19 Infection Using Bioinformatics Tools

de Oliveira Andrade,

de Oliveira,

de Oliveira

et al. 2023

Preprint

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show abstract

“…AGEs can be formed both within the body (endogenously) and in foods during cooking or processing (exogenously). In the context of DM2, endogenous AGEs are of particular interest due to their formation involving a series of chemical reactions that result in the irreversible modification of macromolecules due to cross-linking of proteins, cellular dysfunction, oxidative stress, inflammation and activation of other oxidative stress-related pro-oxidative pathways such as that of PKC when AGEs bind to their receptor [ 256 , 257 ].…”

Section: Effect Of Aging Diseases and Their Treatment On The Redox Ba...mentioning

confidence: 99%

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

Rojas-Solé,

Pinilla-González,

Lillo-Moya

et al. 2023

Redox Report

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Increased life expectancy, attributed to improved access to healthcare and drug development, has led to an increase in multimorbidity, a key contributor to polypharmacy. Polypharmacy is characterised by its association with a variety of adverse events in the older persons. The mechanisms involved in the development of age-related chronic diseases are largely unknown; however, altered redox homeostasis due to ageing is one of the main theories. In this context, the present review explores the development and interaction between different age-related diseases, mainly linked by oxidative stress. In addition, drug interactions in the treatment of various diseases are described, emphasising that the holistic management of older people and their pathologies should prevail over the individual treatment of each condition.

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Down-regulation of O-GlcNAcylation alleviates insulin signaling pathway impairment following arsenic exposure via suppressing the AMPK/mTOR-autophagy pathway

Zhang,

Zeng,

Huang

et al. 2024

Toxicology Letters

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Insulin Receptor Signaling in Health and Disease

Abstract: Since the discovery of insulin over 100 years ago, our understanding of the insulin signaling pathway has greatly expanded [...]

Cited by 3 publications

References 6 publications

A Network Analysis of Molecular Interactions to Study the Development of New-onset Diabetes and Hypertension after COVID-19 Infection Using Bioinformatics Tools

A Network Analysis of Molecular Interactions to Study the Development of New-onset Diabetes and Hypertension after COVID-19 Infection Using Bioinformatics Tools

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

Down-regulation of O-GlcNAcylation alleviates insulin signaling pathway impairment following arsenic exposure via suppressing the AMPK/mTOR-autophagy pathway

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