Insulin receptors in largemouth bass (
            <i>Micropterus salmoides</i>
            ): Cloning, characterization, tissue expression profile and transcriptional response to glucose tolerance test

Li, Songlin; Wang, An; Wei, Zehong; Liu, Ruonan; Wang, Dixin; Chen, Naisong

doi:10.1111/are.14919

Cited by 2 publications

(1 citation statement)

References 43 publications

(72 reference statements)

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“…However, serum insulin content decreased to the lowest level at 3 hours and returned to normal level until 48 hours after IPGTT (Liu et al, 2018). In largemouth bass (Micropterus salmoides), intraperitoneal glucose injection at 500 mg glucose/kg body weight increased serum glucose level that reached the peak after 3 hours and returned to normal level after 12 hours following IPGTT, but IPGTT did not affect the gene expression of insulin receptors (Li et al, 2021). In omnivorous fish, such as zebrafish (Danio rerio) GTT at 1000 mg glucose/kg body weight caused a peak serum glucose level after 0.5 hour and returned to normal level after 6 hour post injection (Eames et al, 2010).…”

Section: Introductionmentioning

confidence: 97%

Comparative analysis of glucose and fructose tolerance in two marine fishes: effects on insulin secretion and acute hypoxia tolerance

Ma,

Xu,

Limbu

et al. 2023

Front. Mar. Sci.

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Carbohydrates are a common and economical energy source in animal feeds. However, most fish show a persistent postprandial hyperglycemia after intake of a high-carbohydrate diet. Unfortunately, the mechanism of glucose metabolism in fish is still unclear. In the present study, tiger puffer (Takifugu rubripes) and turbot (Scophthalmus maximus) were intraperitoneally injected or orally administered with glucose or fructose (500 mg/kg body weight) to evaluate the ability of fish to utilize carbohydrates. Afterwards, serum glucose, fructose, pyruvate, insulin levels, and acute hypoxia tolerance were measured. Our results showed increased serum glucose level and then decreased post intraperitoneal injection with glucose, and reached a peak after 0.5 hours in turbot and 1 hour in tiger puffer. Tiger puffer had significantly lower liver glycogen, serum glucose, fructose, pyruvate, and insulin contents than turbot. Glucose and fructose only induced insulin secretion in turbot, but did not change serum insulin level in tiger puffer. Glucose was a stronger stimulator of insulin than fructose in the two marine species. Both intraperitoneal injection and oral fructose intake increased serum glucose level, while intraperitoneal or oral glucose also increased serum fructose level. Intraperitoneal injection of glucose promoted absorption and utilization of glucose in the blood more effectively than oral glucose intake. In addition, turbot and tiger puffer were intolerant to acute hypoxia, whereas supplementation with glucose or fructose improved hypoxia tolerance in the two marine fishes by activating anaerobic glycolysis. Taken together, our results provide important scientific information for understanding the mechanism for glucose and fructose utilization and improving hypoxia tolerance in fish.

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Section: Introductionmentioning

confidence: 97%