Insulin receptors on leukemia and lymphoma cells

Chen, Po‐Min; Kwan, Siu-hoi; Hwang, Tien-Szu; Chiang, Benjamin N.; Chou, Chen-Kung

doi:10.1182/blood.v62.2.251.251

Cited by 18 publications

(1 citation statement)

References 23 publications

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“…Under normal conditions, healthy cells, including lymphocytes, exhibit low levels of surface insulin receptor (InsR) expression, due to the degradation of InsR following insulin binding [ 109 ]. The upregulation of membrane InsR has been recognized as a tumorigenesis-promoting mechanism in certain solid malignancies and CLL [ 110 ], although corresponding evidence regarding acute leukemias is lacking [ 111 ]. Likewise, IGF-1 receptor in T-ALL is maintained high by Notch signaling [ 112 ], and is induced in B-ALL by HoxA9 overexpression and occasionally in AML, thus promoting leukemogenesis [ 113 , 114 ].…”

Section: Biological Mechanisms Associating Obesity With Leukemiamentioning

confidence: 99%

Obesity and Leukemia: Biological Mechanisms, Perspectives, and Challenges

Tsilingiris,

Vallianou,

Spyrou

et al. 2023

Curr Obes Rep

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Purpose of Review To examine the epidemiological data on obesity and leukemia; evaluate the effect of obesity on leukemia outcomes in childhood acute lymphoblastic leukemia (ALL) survivors; assess the potential mechanisms through which obesity may increase the risk of leukemia; and provide the effects of obesity management on leukemia. Preventive (diet, physical exercise, obesity pharmacotherapy, bariatric surgery) measures, repurposing drugs, candidate therapeutic agents targeting oncogenic pathways of obesity and insulin resistance in leukemia as well as challenges of the COVID-19 pandemic are also discussed. Recent Findings Obesity has been implicated in the development of 13 cancers, such as breast, endometrial, colon, renal, esophageal cancers, and multiple myeloma. Leukemia is estimated to account for approximately 2.5% and 3.1% of all new cancer incidence and mortality, respectively, while it represents the most frequent cancer in children younger than 5 years. Current evidence indicates that obesity may have an impact on the risk of leukemia. Increased birthweight may be associated with the development of childhood leukemia. Obesity is also associated with worse outcomes and increased mortality in leukemic patients. However, there are several limitations and challenges in meta-analyses and epidemiological studies. In addition, weight gain may occur in a substantial number of childhood ALL survivors while the majority of studies have documented an increased risk of relapse and mortality among patients with childhood ALL and obesity. The main pathophysiological pathways linking obesity to leukemia include bone marrow adipose tissue; hormones such as insulin and the insulin-like growth factor system as well as sex hormones; pro-inflammatory cytokines, such as IL-6 and TNF-α; adipocytokines, such as adiponectin, leptin, resistin, and visfatin; dyslipidemia and lipid signaling; chronic low-grade inflammation and oxidative stress; and other emerging mechanisms. Summary Obesity represents a risk factor for leukemia, being among the only known risk factors that could be prevented or modified through weight loss, healthy diet, and physical exercise. Pharmacological interventions, repurposing drugs used for cardiometabolic comorbidities, and bariatric surgery may be recommended for leukemia and obesity-related cancer prevention.

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