1989
DOI: 10.1016/s0021-9258(18)63866-9
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Insulin-regulated Glucose Uptake in Rat Adipocytes Is Mediated by Two Transporter Isoforms Present in at Least Two Vesicle Populations

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Cited by 298 publications
(36 citation statements)
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“…Again, there are no striking differences between the two fractions, although the slowest migrating form of SCAMPs/ GTV3 appears somewhat less abundant in the insulin-sensitive vesicles. As is the case in fat cells, GLUT1 (Zorzano et al, 1989;Kandror et al, 1995a) and caveolin (Kandror et al, 1995b) are completely excluded from the GLUT4-containing vesicles in both sucrose fractions (data not shown).…”
Section: Resultsmentioning
confidence: 51%
“…Again, there are no striking differences between the two fractions, although the slowest migrating form of SCAMPs/ GTV3 appears somewhat less abundant in the insulin-sensitive vesicles. As is the case in fat cells, GLUT1 (Zorzano et al, 1989;Kandror et al, 1995a) and caveolin (Kandror et al, 1995b) are completely excluded from the GLUT4-containing vesicles in both sucrose fractions (data not shown).…”
Section: Resultsmentioning
confidence: 51%
“…In a similar manner, cAMP analogues induced a translocation of GLUT4 to the plasma membrane which was of lower magnitude than that promoted by insulin, but which was not linked to a net increase in transport activity, suggesting that cAMP was involved in phosphorylation of and decrease in intrinsic activity of GLUT4 (Kelada et al, 1992). Even though it has been shown that GLUTI is, but to a lesser extent than GLUT4 (Zorzano et al, 1989), also subjected to translocation processes, little information is available on the regulation of this protein by isoprenaline. It has nevertheless been shown that, unlike GLUT4, GLUTI cannot be phosphorylated by isoprenaline (Nishimura et al, 1991).…”
Section: Introductionmentioning
confidence: 82%
“…It remains to be determined whether the primary function of the GTV is for the intracellular sequestration of GLUT4 under basal conditions or to shuttle GLUT4 molecules to the cell surface after exposure to insulin . It has been proposed that GLUT4 constitutes a substantial proportion of GTV protein (up to 15 %) in adipocytes (Zorzano et al , 1989) . By analogy with secretory granules, this could be an indication that a major function of the GTV is related to GLUT4.…”
Section: Discussionmentioning
confidence: 99%
“…GLUTI is expressed in many cell types, including those that do not normally exhibit insulin-sensitive glucose transport (Mueckler et al ., 1985;Birnbaum et al, 1986;Flier et al ., 1987;Fukumoto et al, 1988). Nevertheless, both isoforms undergo insulin-dependent movement to the cell surface in adipocytes (Zorzano et al, 1989;Holman et al ., 1990;Calderhead et al, 1990;Piper et al ., 1991). These .…”
mentioning
confidence: 99%
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