Insulin release in response to calcium in the diagnosis of insulinoma

Roy, Bhaskar Kumar; Abuid, Juan; Wendorff, Hermann; Nitiyanant, Wannee; DeRubertis, Frederick R.; Field, James B.

doi:10.1016/0026-0495(79)90071-4

Cited by 15 publications

(2 citation statements)

References 14 publications

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“…The intravenous infusion of calcium brings about a rapid rise of serum insulin levels in patients with insulinoma 10,11. Using the same principle as that operation when we used secretin for the localization of gastrinomas, we used calcium solution as a stimulant for the selective arterial stimulant injection test 6,7.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of selective arterial calcium injection test and secretin test in patients with insulinoma

Imamura

Shimada

Kato

et al. 1994

J Hep Bil Pancr Surg

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Preoperatively, it is sometimes very difficult to localize pancreatic endocrine tumors by conventional imaging techniques. Insulinoma is often solitary and benign, but 10% of insulinomas are multiple and malignant. To perform a curative resection of insulinomas, it is important not to leave any tumor postoperatively. In patients with gastrinomas, the selective arterial secretin injection test has been demonstrated to be useful for the curative resection of gastrinomas, since this test tells us whether there is a gastrinoma in the area of interest. The principle of this test is based on the observation that gastrinomas promptly release gastrin when stimulated by secretin. Following a principle analogous to that underlying the secretin test, we have used calcium solution as a stimulant for insulinoma. This selective arterial calcium injection (SACI) test has been used in Kyoto and in National Institute in Health, Bethesda, USA, NIH since 1990. In three patients with insulinoma, curative resection was performed successfully, based on localization by the SACI test. For the differential diagnosis of insulinoma and B cell hyperplasia, we used the intravenous secretin test in 14 patients who had had episodes of hypoglycemia; the test was useful, showing 75% sensitivity and 100% specificity.

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Section: Discussionmentioning

confidence: 99%

Usefulness of selective arterial calcium injection test and secretin test in patients with insulinoma

Imamura

Shimada

Kato

et al. 1994

J Hep Bil Pancr Surg

View full text Add to dashboard Cite

show abstract

“…Since the development of the immunoassay for insulin, ample knowledge concerning insulin secretion has been accumulated (Williams and Ensinck 1966 Gaeke et al 1975;Roy et al 1979). In the present study, responses of plasma insulin to four stimuli, glucose, tolbutamide, glucagon and arginine, were investigated in the patients with insulinoma and the diagnostic value of each test for the disease was compared.…”

Section: Discussionmentioning

confidence: 99%