Insulin-releasing and insulin-like activity of the traditional anti-diabetic plantCoriandrum sativum(coriander)

Abstract

Coriandrum sativum (coriander) has been documented as a traditional treatment of diabetes. In the present study, coriander incorporated into the diet (62⋅5 g/kg) and drinking water (2⋅5 g/l, prepared by 15 min decoction) reduced hyperglycaemia of streptozotocin-diabetic mice. An aqueous extract of coriander (1 mg/ml) increased 2-deoxyglucose transport (1⋅6-fold), glucose oxidation (1⋅4-fold) and incorporation of glucose into glycogen (1⋅7-fold) of isolated murine abdominal muscle comparable with 10 −8 M-insulin. In acute 20 min tests, 0⋅25-10 mg/ml aqueous extract of coriander evoked a stepwise 1⋅3-5⋅7-fold stimulation of insulin secretion from a clonal B-cell line. This effect was abolished by 0⋅5 mM-diazoxide and prior exposure to extract did not alter subsequent stimulation of insulin secretion by 10 mM-L-alanine, thereby negating an effect due to detrimental cell damage. The effect of extract was potentiated by 16⋅7 mM-glucose and 10 mM-L-alanine but not by 1 mM-3-isobutyl-1-methylxanthine. Insulin secretion by hyperpolarized B-cells (16⋅7 mM-glucose, 25 mM-KCl) was further enhanced by the presence of extract. Activity of the extract was found to be heat stable, acetone soluble and unaltered by overnight exposure to acid (0⋅1 M-HCl) or dialysis to remove components with molecular mass Ͻ 2000 Da. Activity was reduced by overnight exposure to alkali (0⋅1 M-NaOH). Sequential extraction with solvents revealed insulin-releasing activity in hexane and water fractions indicating a possible cumulative effect of more than one extract constituent. These results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in Coriandrum sativum.

Effects of coriander (<i>Coriandrum sativum</i> L.) seed powder and extract on performance of broiler chickens

“…After 24 h maceration at room temperature (37 ºC), the mixture was heated for 30 minutes in a water bath set to 65 ºC. The extract was filtered, concentrated by heating over the water bath (65 ºC), and dried under vacuum (Gray & Flatt, 1999) with a yield of 5.9% (w/w). The extract was stored at 4 ºC and used in the experiment as needed.…”

Antimicrobial and Antifungal Activity of Volatile Extracts of 10 Herb Species against Glomerella cingulata

“…In addition to its use as seasoning, coriander has traditionally been used for its analgesic, aphrodisiac, antirheumatic, anti-inflammatory, diuretic, antispasmodic, circulatory stimulant, and antidiabetic effects (Gray & Flatt, 1999), and more recently for its possible cholesterol-lowering (hypolipidemic) effects (Momin et al, 2012). The essential oil extracted from coriander seeds has been reported to have antimicrobial activity against both gram-negative and gram-positive foodborne pathogenic bacteria, including E. coli O157: H7, L. monocytogenes, S. aureus, B. cereus, Enterococcus faecalis, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii (Alves-Silva et al, 2013), and Candida spp.…”

In vitro free radical scavenging and DNA damage protective property of Coriandrum sativum L. leaves extract

“…Different parts of the plant, including the fruits and the green herbs, are used for medicinal purposes such as dyspeptic complaints and loss of appetite (Blumenthal et al 2000). Pharmacological studies in animals have shown that coriander has anti-diabetic (Swanston-Flatt et al 1990;Gray and Flatt 1999), hypolipidemic, (Chithra and Leelamma 1997; and anti-cancer effects (Chithra and Leelamma 2000). Sedative-hypnotic activity of coriander seeds have been evaluated in scientific studies in mice (Emamghoreishi et al 2005).…”