Insulin resistance

Ray, Ahmed El; Asselah, Tarik; Moucari, Rami; Ghannam, Maged El; Taha, Alaa; Saber, Mohamed; Akl, Maha; Atta, Raafat; Shemis, Mohamed; Radwan, Azza Saleh; Ghali, Ayman; Paradis, Valérie; Marcellin, Patrick

doi:10.1097/meg.0b013e32835c9f69

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…In another study of chronic HCV patients [ 56 ], obese patients had a greater risk of advanced fibrosis. Similar results were found by El-Ray et al in Egypt [ 55 ]. The harmful effects of obesity are caused by a state of chronic metabolic inflammation induced in the liver, which may predispose individuals to liver fibrosis and non-alcoholic fatty liver disease.…”

Section: Discussionsupporting

confidence: 92%

“…In our study, patients’ body mass index was significantly associated with the risk of liver fibrosis, as obese HIV-HCV co-infected patients were six times more likely to have ALF. Several studies have shown a strong association between obesity and disease progression in chronic HCV patients [ 54 , 55 , 56 , 57 ]. In a study of an American cohort of chronic HCV patients with available liver biopsies, Younossi et al [ 57 ] highlighted that overweight and obese patients were much more likely to have advanced fibrosis.…”

Section: Discussionmentioning

confidence: 99%

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Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS CO-13 HEPAVIH Cohort)

et al. 2018

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Background: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. Methods: ANRS CO13-HEPAVIH is a French, nationwide, multicenter cohort of HIV-HCV-co-infected patients. Sociodemographic, behavioral, and clinical data including alcohol and coffee consumption were prospectively collected using annual self-administered questionnaires during five years of follow-up. Mixed logistic regression models were performed, relating coffee intake and alcohol consumption to ALF. Results: 1019 patients were included. At the last available visit, 5.8% reported high-risk alcohol consumption, 27.4% reported high coffee intake and 14.5% had ALF. Compared with patients with low coffee intake and high-risk alcohol consumption, patients with low coffee intake and low-risk alcohol consumption had a lower risk of ALF (aOR (95% CI) 0.24 (0.12–0.50)). In addition, patients with high coffee intake had a lower risk of ALF than the reference group (0.14 (0.03–0.64) in high-risk alcohol drinkers and 0.11 (0.05–0.25) in low-risk alcohol drinkers). Conclusions: High coffee intake was associated with a low risk of liver fibrosis even in HIV-HCV co-infected patients with high-risk alcohol consumption.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS CO-13 HEPAVIH Cohort)

et al. 2018

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“…Among their findings, the onset of liver fibrosis ranged between 5 to 15.2 years. While one systematic review of 57 articles estimated that cirrhosis onset after 20 years of chronic HCV infection was 22% for the liver clinic series [77]. Therefore, it seems that HIV/HCV coinfection would shorten the onset of cirrhosis development.…”

Section: Discussionmentioning

confidence: 99%

Important Risk Factors of Liver Cirrhosis in HIV and Hepatitis C Coinfected Patients: A Systematic Review

Mehraeen,

Janfaza,

Shahidi

et al. 2024

TOAIDJ

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Introduction Hepatitis C virus (HCV) is the leading cause of chronic hepatitis and liver fibrosis. Due to shared modes of transmission with human immunodeficiency virus (HIV), HIV-HCV coinfection is also common worldwide. Multiple studies have shown that the rates of liver fibrosis and associated complications increase considerably in this sub-population compared to a single HCV infection. Thus, in this study, we aimed to conduct a systematic review of possible associated important risk factors of accelerated liver cirrhosis among HIV-HCV coinfected subjects. Methods A systematic review of published studies relevant to the main risk factors of liver cirrhosis progression in HIV and hepatitis C coinfected patients was performed using databases of PubMed, Web of Science, Scopus, and Embase were searched using keywords and their combinations. We retrieved all the relevant papers and reports published in English till 27 June 2022, which were examined by applying inclusion/exclusion criteria for data extraction after a two-step screening process. Results The long-term or chronic hepatitis C and HIV coinfection is a substantial risk factor for Cirrhosis. Primary etiologies identified causing fibrosis, and the rapid progression of Cirrhosis in HIV/HCV coinfected patients include high-risk alcohol consumption, chronic elevation of ALT, AST, Aspartate Aminotransferase to Platelet Ratio Index (APRI) and Gamma-glutamyl Transferase (GGT), Body Mass Index (BMI), older age, high HIV and HCV viral loads, lower CD4+ count (<250/mm3), and male gender. Comorbidities such as diabetes, hypertension, hyperlipidemia, and high visceral fat area are suggested etiologies of cirrhosis. Conclusion The results showed that HIV accelerates the progression of HCV-related liver disease independent of its effect on the immune system. This effect is somehow dependent on age, gender, BMI, duration of HIV infection, and CD4 count.

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“…Diabetes mellitus is a significant risk factor for advanced fibrosis in patients with NAFLD [ 29 ]. Insulin resistance is also a major factor associated with NAFLD and significant liver fibrosis [ 30 , 31 ]. NAFLD itself was a multisystem disease and associated with factors that mediate interindividual variations in the development of extrahepatic manifestations including type 2 diabetes mellitus [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic Fat Content and Markers of Hepatic Fibrosis in Obese Children

Zhang

et al. 2016

International Journal of Endocrinology

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Aim. We evaluated both direct and indirect hepatic fibrosis markers in obese children and their relationship with intrahepatic fat (IHF) content. We also aimed to investigate the possible roles of IHF and fibrosis markers in metabolic syndrome (MS). Methods. 189 obese children were divided into simple obese (SOB), simple steatosis (SS), and nonalcoholic steatohepatitis (NASH) groups according to their IHF and blood alanine transaminase (ALT) levels. They were also scored for the MS components. IHF was assessed as a continuous variable by proton magnetic resonance spectroscopy (1H-MRS). In addition, 30 nonobese children were enrolled as controls and their direct hepatic fibrosis markers and IHF were assessed. Results. Age was related to IHF, NFS, and FIB-4. Both NFS and APRI were related to IHF more significantly than the direct markers. In the estimation of liver function impairment, indirect markers had greater AUROC than direct markers. In MS, IHF and all the fibrosis markers showed similar AUROC. Conclusions. Both direct and indirect markers played a valuable role in evaluating MS. Indirect markers were more effective in distinguishing fatty hepatitis. Age is an important factor underlying hepatic steatosis and fibrosis even in children.

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Insulin resistance

Abstract: In CHC-4 patients, IR is highly prevalent and independently associated with age, obesity, SF, and severe steatosis. Management of IR might significantly improve the prognosis of CHC-4 patients.

Cited by 15 publications

References 25 publications

Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS CO-13 HEPAVIH Cohort)

Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS CO-13 HEPAVIH Cohort)

Important Risk Factors of Liver Cirrhosis in HIV and Hepatitis C Coinfected Patients: A Systematic Review

Intrahepatic Fat Content and Markers of Hepatic Fibrosis in Obese Children

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