2012
DOI: 10.1007/s11325-012-0708-0
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Insulin resistance and adipose-derived hormones in young men with untreated obstructive sleep apnea

Abstract: These findings suggest that excess CAF in young men with OSA may contribute to risk for type 2 diabetes indirectly by a degree that would otherwise not be reached through obesity, although further research is needed.

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Cited by 36 publications
(30 citation statements)
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“…While the effect of hypoxia is known to induce compensatory increase in circulating leptin, less well known is the effect of OSA on adiponectin. In agreement with previous studies [21, 23], we have found lower adiponectin in association with OSA severity suggesting that it could be a good disease marker. Hypoxia has been shown to reduce adiponectin levels via disruption of mechanisms that regulate the production and secretion of adiponectin [34, 35].…”
Section: Discussionsupporting
confidence: 93%
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“…While the effect of hypoxia is known to induce compensatory increase in circulating leptin, less well known is the effect of OSA on adiponectin. In agreement with previous studies [21, 23], we have found lower adiponectin in association with OSA severity suggesting that it could be a good disease marker. Hypoxia has been shown to reduce adiponectin levels via disruption of mechanisms that regulate the production and secretion of adiponectin [34, 35].…”
Section: Discussionsupporting
confidence: 93%
“…Nevertheless, other factors such as insulin resistance and hypoxia-induced sympathetic activation may also play significant roles [36, 37]. With regard to insulin resistance, our results are in agreement with previous reports [22, 23, 38] that showed that the association between insulin resistance and OSA could be explained by differences in BMI and other confounding variables (Table 4). However, it is pertinent to noting that insulin resistance is widely prevalent in our subjects as the HOMA-IR results (Table 2) are much higher than reported in previous studies from the same population [29].…”
Section: Discussionsupporting
confidence: 93%
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“…Adiponectin levels are significantly lower in patients with OSAS being related to its severity and arterial oxygen saturation. Hargens et al confirmed that adiponectin levels are lower in the OSAS patients compared to controls [117]. However, two recent works indicate that adiponectin levels are not affected in OSAS.…”
Section: Adiponectin and Obesity-related Diseasesmentioning
confidence: 99%
“…OSA affects 3%∼7% of adult men, 2%∼5% of adult women [1]–[3], and up to 4% of children [4]. OSA is associated with complications in different organ systems, such as cardiovascular morbidities, hypertension, obesity, dyslipidemia, insulin resistance (IR) [5], [6], diabetes [7] and metabolic syndrome [8], [9]. Although the influence of obesity likely exaggerates this risk, recent clinical studies suggest that IR and glucose intolerance are positively associated with OSA, independent of the degree of obesity [10].…”
Section: Introductionmentioning
confidence: 99%