Insulin resistance and body composition in preterm born children during prepubertal ages

Darendelıler, Feyza; Baş, Firdevs; Bundak, Rüveyde; Çoban, Asuman; Sancakli, Ozlem; Eryilmaz, Sema; Kucukemre, Banu; Dişçi, Rian; Gökçay, Gülbin; Aki, Semih; İnce, Zeynep; Eskiyurt, Nurten

doi:10.1111/j.1365-2265.2007.03119.x

Cited by 46 publications

(61 citation statements)

References 43 publications

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“…As has been shown in the previous report (20), insulin was significantly higher in term SGA children than in term AGA children (PZ0.003) and higher than in preterm SGA children (P!0.001). Preterm SGA and preterm AGA children had similar insulin levels.…”

Section: Resultssupporting

confidence: 66%

“…In fact, insulin level was one of the major determinants of ghrelin levels in our study. We, along with other investigators, have shown that SGA born children may have higher insulin levels in early childhood in spite of normal BMI levels (20,(26)(27)(28), and it has been shown that ghrelin has inverse correlation with insulin (5).…”

Section: Discussionmentioning

confidence: 99%

“…After an overnight fast, serum samples were drawn for serum insulin, glucose, and ghrelin levels. Among other parameters concerning insulin resistance in this cohort of children that have been presented in the previous report (20), only the results of insulin and glucose measurements will be given in conjunction with ghrelin levels in this study. HOMA-IR was calculated as insulin (mU/ml)!glucose (mmol/l)/22.5 (24).…”

Section: Methodsmentioning

confidence: 99%

“…Detailed methods regarding recruitment of the subjects in this study and regarding the collection of medical history and physical examination in these children have been recently given in detail in this previous report (20). BMI of the children was calculated as weight (kg)/height (m) 2 .…”

Section: Methodsmentioning

confidence: 99%

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Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Darendelıler

Baş²,

Bundak³

et al. 2008

European Journal of Endocrinology

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Background: Ghrelin, the natural ligand of the GH secretagogue receptor, has potent orexigenic effect. Ghrelin levels are negatively associated with insulin secretion, increased in anorexia, and reduced in obesity. Increased ghrelin levels may be associated with early postnatal growth in preterm born children. Objective: Aim of this study was to evaluate ghrelin and insulin levels at prepubertal ages in preterm born children born appropriate for gestational age (AGA) or small for gestational age (SGA) and relationships with catch-up growth (CUG) in a prospective cross-sectional study. Methods: Eighty-four preterm born children grouped as preterm SGA (nZ28) and preterm AGA (nZ56) were evaluated at age 4.7G0.2 and 4.7G0.1 years with respect to their ghrelin and insulin levels. Their data were compared with that of body mass index matched term SGA (nZ35) and term AGA (nZ44) children of age 4.6G0.2 and 3.8G0.1 years. All children had height appropriate for their target height. CUG was defined as the difference between birth size and recent size and expressed as D height and D weight SDS. Results: Preterm SGA and preterm AGA children had similar ghrelin levels (1717.0G166.9 and 1656.5G103.8 pg/ml), although D height and D weight SDS in preterm SGA were significantly higher than in preterm AGA children (P!0.001). Ghrelin levels in both preterm groups were higher than term SGA (469.2G132.5 pg/ml) and term AGA children (659.6G143.3 pg/ml; P!0.001 for all). D Height and D weight SDS of the term SGA children were similar to that of preterm SGA children. Ghrelin did not have correlation with CUG but had inverse correlation with recent anthropometric indices. Insulin was significantly higher in term SGA children than other groups (P!0.001). Conclusions: Preterm children have higher ghrelin levels at prepubertal ages regardless of the magnitude of their CUG. Term SGA children, on the other hand, behave differently and have lower ghrelin levels than preterm children at prepubertal ages, which may be related to elevated insulin levels in this group.

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Section: Resultssupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Darendelıler

Baş²,

Bundak³

et al. 2008

European Journal of Endocrinology

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“…In the offspring, low maternal vitamin B 12 status during pregnancy is associated with increased risk of neural tube defect, low lean mass and excess adiposity, increased insulin resistance, impaired neurodevelopment and altered risk of cancer (Rush et al 2014). In addition, children born with alteration of growth fetal development had a greater risk during adulthood of metabolic disorders and chronic illnesses (Darendeliler et al 2008). The current standard for prenatal care promotes preventive use of folic acid supplementation, but not the vitamin B 12 .…”

Section: Resultsmentioning

confidence: 99%

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

et al. 2014

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In this study, we evaluated the effects of dietary intake of vitamin B 12 and folate during pregnancy and their interactions with maternal polymorphism of MTHFR (677C[T; 1298A[C) on intrauterine development. Anthropometric parameters were obtained from 231 newborns that belong to a prospective birth cohort in Morelos, Mexico. Maternal dietary intake of vitamin B 12 and folate was assessed using a semi-quantitative questionnaire administered during the first and third trimesters of the pregnancy. Maternal MTHFR 677C[T and 1298 A[C genotypes were determined by PCR-RFLP. The associations between deficient dietary intake of vitamin B 12 (\2.0 lg/d) and folate (\400 lg/d) in the first and third trimesters and maternal polymorphisms of MTHFR on anthropometric parameters at birth were estimated using a multivariate linear regression model. During pregnancy, the deficient dietary intake was roughly 60 % for folate and 19 % for vitamin B 12 . Allelic frequencies of 677T and 1298C were 59 and 10 %, respectively. After adjusting for confounders, deficiency in maternal dietary intake of vitamin B 12 (\2.0 lg/d) was associated with a significant reduction in length (b * -2.4; 95 % CI -4.3; -0.6) and length-for-age at birth (b * -1.2; 95 % CI -2.3; -0.1) among infants whose mothers were carriers of the 677TT genotype (p for interaction = 0.02). In contrast, no association was observed between deficiency in maternal dietary intake of folate (\400 lg/d) and any anthropometric parameter of newborns. These results suggest that supplementation with vitamin B 12 during pregnancy could have a favorable impact on intrauterine fetal development mainly in populations that are genetically susceptible.

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Late prematurity and adiposity in adolescents: Evidence from “Children of 1997” birth cohort

Hui

Lam

Leung

et al. 2015

Obesity

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Insulin resistance and body composition in preterm born children during prepubertal ages

Cited by 46 publications

References 43 publications

Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Elevated ghrelin levels in preterm born children during prepubertal ages and relationship with catch-up growth

Maternal dietary intake of folate, vitamin B12 and MTHFR 677C>T genotype: their impact on newborn’s anthropometric parameters

Late prematurity and adiposity in adolescents: Evidence from “Children of 1997” birth cohort

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