Insulin resistance and cancer: epidemiological evidence

Inoue, Manami; Tsugane, Shoichiro

doi:10.1530/erc-12-0142

Cited by 87 publications

(55 citation statements)

References 60 publications

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“…After reviewing several studies, Crimmins et al (Crimmins and Martin, 2007) reported that rs1342387 was the only single nucleotide polymorphism (SNP) of adiponectin receptor 1 which was significantly associated with HOMA-IR as a measure of insulin resistance. Present studies had shown that obesity and insulin resistance were risk factors of kinds of cancers (Inoue and Tsugane, 2012;Vucenik and Stains, 2012). And Insulin levels were shown to be correlated with the expression of adiponectin receptors (Tsuchida et al, 2004), which could be downregulated by obesity and in turn lead to insulin resistance (Ouchi et al, 2000).…”

Section: Discussionmentioning

confidence: 97%

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Cui

Zhou²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (18), 7515-7520 IntroductionCancer and obesity are two major public health problems of this century. In 2008, an estimated 12.7 million new cancer cases and 7.6 million cancer deaths occurred all over the world (Ferlay et al., 2010), and in the same year, about 1.46 billion adults were overweight worldwide, of whom estimated 500 million adults were obese (Finucane et al., 2011). Epidemiological studies had established that increasing of BMI and excess body weight were risk factors for some cancers, such as colorectal cancer, prostate cancer and renal cancer, which were called obesity-related cancers (Renehan et al., 2008;Vucenik and Stains, 2012). Recent studies had revealed that adiponectin, the most abundant adiposetissue protein, was a key player in the development and progression of obesity-related cancers (Barb et al., 2007;Paz-Filho et al., 2011;Liu et al., 2013). Adiponectin is involved in anti-inflammatory, insulin-sensitizing, and anti-proliferation activities which are associated with the development of cancer (Barb et al., 2007;Ziemke and Mantzoros, 2010). Recent studies have confirmed that adiponectin implement the main biological function by signaling through its receptors-ADIPOR 1 and ADIPOR

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Section: Discussionmentioning

confidence: 97%

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Cui

Zhou²,

Liu³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…IR is a condition in which the body produces sufficient insulin to take up and use glucose, but the sensitivity to this insulin is impaired or selective, thus causing pancreatic b-cells to upregulate insulin production as a compensatory mechanism, which results in hyperinsulinemia. There are several studies linking hyperinsulinemia and the risk and/or aggressiveness of colorectal, pancreatic, liver, esophageal, breast, and endometrial cancers (Gunter et al 2008, Arcidiacono et al 2012, Inoue & Tsugane 2012, Qiu et al 2012, Zhan et al 2013. Thyroid nodules follow the same trend (Rezzonico et al 2008).…”

Section: Ir and The Role Of Igf1mentioning

confidence: 99%

Obesity and thyroid cancer

Marcello,

Cunha,

Batista

et al. 2014

Endocrine Related Cancer

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Many studies have provided observational data on the association of obesity and thyroid cancers, but only few of them propose mechanisms that would permit a better understanding of the causal molecular mechanisms of this association. Considering that there is an increasing incidence of both obesity and thyroid cancers, we need to summarize and link recent studies in order to characterize and understand the contribution of obesity-related factors that might affect thyroid cancer development and progression. Adipose tissue is involved in many vital processes, including insulin sensitivity, angiogenesis, regulation of energy balance, activation of the complement system, and responses such as inflammation. Although these processes have their own molecular pathways, they involve the same molecules through which obesity and adipose tissue might exert their roles in carcinogenesis, not only affecting MAPK and PI3K or even insulin pathways, but also recruiting local inflammatory responses that could result in disease formation and progression. This review describes five important issues that might explain the link between excessive weight and thyroid cancer: thyroid hormones, insulin resistance, adipokines, inflammation, and sexual hormones.

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“…Metabolic syndrome and insulin resistance have been associated with increased risk of cancer, including cardia gastric cancers (42,43). This is mediated by adipokines and cytokines released by metabolically active visceral fat, which result in chronic hyperinsulinemia and increase risk of insulin-like growth factormediated carcinonogenesis (44). Exercise decreases visceral fat, lowering the level of carcinogenic adipocytokines, improves insulin sensitivity and reduces fasting insulin and C-peptide levels, and may decrease insulin-like growth factor-I (12).…”

Section: Mechanism Of Actionmentioning

confidence: 99%

Physical Activity Is Associated with Reduced Risk of Gastric Cancer: A Systematic Review and Meta-analysis

Singh

Varayil

Devanna

et al. 2014

Cancer Prevention Research

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Physical activity may be associated with reduced risk of gastric cancer. We performed a systematic review and meta-analysis to evaluate the magnitude of the association and the quality of supporting evidence. After a comprehensive search of bibliographic databases and conference proceedings through February 2013 for observational studies that examined associations between recreational and/or occupational physical activity and gastric cancer risk, we identified 16 studies (seven cohort, nine case control) reporting 11,111 cases of gastric cancer among 1,606,760 patients. Summary adjusted-OR estimates with 95% confidence intervals (CI) were estimated using the random-effects model. Meta-analysis demonstrated that the risk of gastric cancer was 21% lower among the most physically active people as compared with the least physically active people (OR ¼ 0.79; 95% CI, 0.71-0.87) with moderate heterogeneity among studies (I 2 ¼ 55%). This protective effect was seen for gastric cancers in the cardia (four studies; OR ¼ 0.80; 95% CI, 0.63-1.00) and distal stomach (five studies; OR ¼ 0.63; 95% CI, 0.52-0.76). The effect size was significantly smaller in highquality studies (six studies; OR ¼ 0.86; 95% CI, 0.75-0.99), as compared with low-quality studies (10 studies; OR ¼ 0.74; 95% CI, 0.69-0.81). The results were consistent across sex, study quality, study design, and geographic location. In conclusion, meta-analysis of published observational studies indicates that physical activity is associated with reduced risk of gastric cancer. Lifestyle interventions focusing on increasing physical activity may decrease the global burden of gastric cancer, in addition to a myriad of other health benefits. Cancer Prev Res; 7(1); 12-22. Ó2013 AACR.

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Insulin resistance and cancer: epidemiological evidence

Cited by 87 publications

References 60 publications

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Adiponectin Receptor 1 (ADIPOR1) rs1342387 Polymorphism and Risk of Cancer: a Meta-analysis

Obesity and thyroid cancer

Physical Activity Is Associated with Reduced Risk of Gastric Cancer: A Systematic Review and Meta-analysis

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