Insulin Resistance and Cardiomyopathy

Huang, Jiung-Pang; Hung, Li-Man

doi:10.5772/28235

Cited by 2 publications

(3 citation statements)

References 145 publications

(138 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They seem to disturb insulin-induced glucose metabolism thereby significantly worsen the metabolic efficiency in cardiac and skeletal muscles. Insulin exerts its insulting effect in the diabetic heart via two processes involving the abnormalities of systemic metabolism and insulin signaling pathways, both of which are intrinsic to the cardiac tissue [45]. In the evolution of IR, the initial change that develops in Mechanisms of Diabetes Mellitus-Induced Sudden Cardiac Death DOI: http://dx.doi.org/10.5772/intechopen.93729 the hearts of animal models is the impairment in the ability of insulin to increase glucose transport [46].…”

Section: Metabolic Disturbances and Sudden Cardiac Deathmentioning

confidence: 99%

“…IR is also associated with cardiac contractile dysfunction and SCD [47]. Moreover, IR is associated with metabolic alteration and the development of DC [45]. Circulating FAs and triglyceride (TG) are increased by enhanced lipolysis in adipose tissue and lipoprotein synthesis in liver as a result of hyperglycemia and IR.…”

Section: Metabolic Disturbances and Sudden Cardiac Deathmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of Diabetes Mellitus-Induced Sudden Cardiac Death

Smail¹,

Howarth²,

Singh³

et al. 2020

Sudden Cardiac Death

View full text Add to dashboard Cite

More than 450 million people worldwide have diabetes mellitus (DM), a metabolic disorder characterized by an increase in blood glucose level (hyperglycemia) that arises from insufficient insulin secretion or resistance to insulin’s action. More than 70% of individuals with chronic DM will develop cardiovascular diseases (CVDs) including atherosclerosis and coronary artery diseases (CADs), hypertension, cardiac arrhythmias, cardiomyopathy (heart failure), stroke, and chronic kidney disease. A significant number of these individuals will also succumb to sudden cardiac death (SCD). SCD usually occurs in early morning from abnormal heart rhythms or arrhythmias and ventricular fibrillation. When the pumping action of the heart becomes erratic, a reduction in oxygenated blood to the brain leads to unconsciousness and brain damage. SCD is independent of age and sex and positively correlates with impairment in cardiac metabolism, muscle damage, fibrosis, apoptosis, hypertrophy, ischemia, and deranged cation signaling. This review centers on mechanisms by which intracellular cations (Na+, K+, and Ca2+) handling, inflammation, and oxidative and carbonyl stresses due to diabetes-induced hyperglycemia can lead to the deterioration of excitation/contraction coupling (ECC), impaired contractility, arrhythmias, and SCD in DM patients. It also discusses the beneficial effects of exercise training to attenuate the risk of SCD.

show abstract

Section: Metabolic Disturbances and Sudden Cardiac Deathmentioning

confidence: 99%

Section: Metabolic Disturbances and Sudden Cardiac Deathmentioning

confidence: 99%

Mechanisms of Diabetes Mellitus-Induced Sudden Cardiac Death

Smail¹,

Howarth²,

Singh³

et al. 2020

Sudden Cardiac Death

View full text Add to dashboard Cite

show abstract

“…A disruption of insulin-mediated glucose metabolism occurs during IR and hyperinsulinemia which can significantly alter the efficiency of metabolism in cardiac muscle as well as skeletal muscle. The diabetic heart is affected by insulin in both systematic metabolism abnormalities via direct effects on insulin signalling pathways in the myocardium [62]. The early recognised change in insulin resistance in the heart is the impaired ability of insulin to increase glucose transport [63].…”

Section: Diabetes Induced Cardiomyopathy (Dcm)mentioning

confidence: 99%

Inflammation and Diabetic Cardiomyopathy

Smail¹,

Howarth²,

Singh³

et al. 2019

Inflammatory Heart Diseases

View full text Add to dashboard Cite

Diabetes mellitus (DM) is a metabolic syndrome that manifests a low grade of systemic inflammation that contributes to the development of cardiovascular diseases (CVDs). DM is a predominant risk factor for CVDs inducing structural changes in the heart, infiltration of fibrosis, apoptosis, and cardiac remodeling, all leading to myocardial infarction (MI), heart failure (HF), and sudden cardiac death. Furthermore, more than 80% of diabetic patients usually die from heart diseases or diabetic cardiomyopathy (DCM). Currently, HF is one of the main causes of mortality in the world despite advances in drug treatments. According to literature, a strong association exists between chronic inflammation and the development of DCM. In order to have a better appreciation of the effect of diabetes and inflammation on the cardiovascular system (CVS), it is of paramount importance to have a better understanding of diabetes, the physiology of the CVS, and the pathophysiology of DM. Thus, the present review highlights the role of chronic inflammation in the complex interplay between the development of DM and DCM. Our understanding of the process is critical in the discovery of new targeted therapies for DCM and other forms of HF.

show abstract

Insulin Resistance and Cardiomyopathy

Cited by 2 publications

References 145 publications

Mechanisms of Diabetes Mellitus-Induced Sudden Cardiac Death

Mechanisms of Diabetes Mellitus-Induced Sudden Cardiac Death

Inflammation and Diabetic Cardiomyopathy

Contact Info

Product

Resources

About