Insulin Resistance and Chronic Hepatitis C: Relationship With Serum Iron and Hepcidin

Gill, Maria; Qamar, Misbah Ul; Ikram, Faiza; Naz, Shaheena; Sadaf, Hina; Hafeez, Zobiah

doi:10.7759/cureus.12349

Cited by 2 publications

(1 citation statement)

References 21 publications

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“…Insulin resistance plays a participating role in the development of left ventricular hypertrophy [12] . Earlier studies also revealed that, HCV infection is associated with the development of insulin resistance, through direct interaction between viral products and different signaling pathways of insulin [13,14]. The eradication of HCV infection induced a significant reduction of insulin resistance and could prevent the development of type-2 diabetes [ 15,16] .…”

Section: Discussionmentioning

confidence: 99%

Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV

Hassib

Elraouf

Biomy

et al. 2021

International Journal of Medical Arts

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Background: Diabetes mellitus [DB] is a well-known risk factor for cardiovascular disease. The co-existence of DM and microvascular abnormalities could lead to hypertrophy of left ventricle [LV] with diastolic and/or systolic dysfunction. However, early stages of the disease are asymptomatic due to its chronic nature and the effective control of diabetes. Aim of the Work: This clinical cohort aimed to assess left ventricular systolic function in DM patients, receiving direct acting antiviral [DAA] drugs for chronic hepatitis-C virus by speckle tracking. Patients and Methods: This clinical cohort included 90 patients who were divided into three equal groups. Patients were recruited from Hepatology Outpatient Clinic of Kafr El-Shaikh University hospital, who were sent to the cardiovascular department for evaluation. Patients were evaluated just before, one month and three months after starting therapy.Result: No one in control group had diastolic dysfunction compared to 10.0% and 16.7% in DAAs and Non-DAAs groups, respectively. Conventional echocardiography returned statistically non-significant difference except significant increase of LVESD, IVST and LVPWT in study groups than control groups. However, the difference between DAAs and Non-DAAs groups was statistically non-significant. The basic strain parameters returned significant lower values at different windows in control than study groups. The strains were reduced in the follow up visits [first and third months] in DAAs groups, but not significantly reduced in non-DAAs group. Acute myocardial infarction was reported among one patient in non-DAAs group compared to none in DAAs group. Conclusion:The speckle tracking is a useful tool for early detection of subclinical left ventricular dysfunction in HCV diabetic patients and could be used for following up of response DAA treatment. DAAs therapy is associated with improvement, not of HCV disease, but also of cardiac dysfunction.

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Section: Discussionmentioning

confidence: 99%

Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV

Hassib

Elraouf

Biomy

et al. 2021

International Journal of Medical Arts

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Iron homeostasis and insulin sensitivity: unraveling the complex interactions

Sobieska,

Buczyńska,

Krętowski

et al. 2024

Rev Endocr Metab Disord

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Diabetes has arisen as a noteworthy global health issue, marked by escalating incidence and mortality rates. Insulin, crucial for preserving euglycemia, acts as a vital energy provider for various tissues. Iron metabolism notably plays a significant role in the development of insulin resistance, a key factor in the onset of various metabolic disorders. The intricate interaction between iron and insulin signaling encompasses complex regulatory mechanisms at the molecular level, thereby impacting cellular reactions to insulin. The intricate interplay between insulin and glucagon, essential for precise regulation of hepatic glucose production and systemic glucose levels, may be influenced by certain microelements for instance zinc, copper, iron, boron, calcium, cobalt, chromium, iodine, magnesium and selenium. While significant progress has been achieved in elucidating the pathophysiological connections between iron overload and glucose metabolism, our understanding of the involvement of the Fenton reaction and oxidative stress in insulin resistance influencing many chronical conditions remains limited. Furthermore, the exploration of the multifaceted roles of insulin in the human body continues to be a subject of active investigation by numerous scientific researchers. This review comprehensively outlines the potential adverse impact of iron overload on insulin function and glucose metabolism. Additionally, we provide a synthesis of findings derived from various research domains, encompassing population studies, animal models, and clinical investigations, to scrutinize the multifaceted relationship between iron and insulin sensitivity. Moreover, we delineate instances of correlations between serum iron levels and various medical conditions, including the diabetes also gestational diabetes and obesity.

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Insulin Resistance and Chronic Hepatitis C: Relationship With Serum Iron and Hepcidin

Cited by 2 publications

References 21 publications

Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV

Assessment of Left Ventricular Systolic Function by Speckle Tracking in Diabetic Patients Receiving Direct Acting Antiviral Drugs for Chronic HCV

Iron homeostasis and insulin sensitivity: unraveling the complex interactions

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