Insulin resistance and dyslipidaemia in obese premenopausal and postmenopausal women matched for leg/trunk fat mass ratio

Aasen, Gunnar; Fagertun, Hans; Halse, Johan

doi:10.1080/00365510902778734

Cited by 12 publications

(14 citation statements)

References 40 publications

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“…40,41 The determination of trFM/lFM ratio is a validated marker of insulin resistance. 23,24 Furthermore, evaluation of trFM/ lFM ratio takes into account the subcutaneous fat and Bariatric surgery and cardiometabolic risk factors C Lubrano et al characterizes a more metabolically benign phenotype of obesity. 42 It is noteworthy that BIBP patients showed more pronounced reduction of trFM and of trFM/lFM than LAGB at all time intervals.…”

Section: Discussionmentioning

confidence: 99%

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Metabolic or bariatric surgery? Long-term effects of malabsorptive vs restrictive bariatric techniques on body composition and cardiometabolic risk factors

et al. 2010

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Background: Obesity is an increasing health problem and surgery seems to be the only treatment effective in achieving weight loss without relapse. Among bariatric techniques, many differences exist in terms of weight loss and resolution of comorbidities. Up to now, there are no prospective studies comparing long-term effects of malabsorptive vs restrictive techniques. Objective: In this study, cardiometabolic risk factors and body composition changes after malabsorptive biliointestinal bypass (BIBP) and restrictive laparoscopic adjustable gastric banding (LAGB) were compared during a 4-year follow-up. Design: Prospective, case-control and cohort study. Patients: In all, 80 obese subjects, matched for weight and age. Altogether, 40 patients underwent BIBP and 40 underwent LAGB. Measurements: Weight, body composition, fasting and post-loading plasma glucose and insulin, homeostatic model assessment index (HOMA-I), lipid profile, blood pressure (BP), erythrocyte sedimentation rate and fibrinogen were monitored at baseline, 12 and 48 months. Results: At 12 months after surgery, a significant reduction in body mass index, total fat mass (FM), trunk FM (trFM), trFM/legs FM (lFM) ratio (trFM/lFM), triglycerides, BP and inflammation markers was observed in both groups. BIBP patients showed a significant reduction in total cholesterol (Tot-C), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), whereas the LAGB group showed a significant increase of HDL-C. A further improvement of all the parameters evaluated was seen in the BIBP group at 48 months after surgery. Conclusions: Both bariatric procedures exerted positive effects on cardiometabolic risk factors and on weight loss in the population studied, but on the long-term period, HOMA-I, Tot-C/HDL-C ratio and body composition improvements were more evident after BIBP. We conclude that malabsorptive BIBP seems to be more effective than LAGB in treating visceral obesity and its metabolic complications

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Section: Discussionmentioning

confidence: 99%

“…Before each scanning session, the Hologic QDR 4500W was calibrated according to the standard procedures recommended by the manufacturer. [19][20][21][22][23][24] BP was measured by a mercury sphygmomanometer (Riva-Rocci System, ERKA, Chemnitz, Germany).…”

Section: Assessmentmentioning

confidence: 99%

Metabolic or bariatric surgery? Long-term effects of malabsorptive vs restrictive bariatric techniques on body composition and cardiometabolic risk factors

et al. 2010

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“…Overweight and obesity are associated with a higher risk of cardiovascular disease and cancer [3], though they are modifiable risk factors. The regional distribution of fat mass (FM) also seems to correlate with different risk levels, even better than the BMI [4]; while a high cardiovascular risk is associated with abdominal FM, several studies have suggested that FM in the lower limbs has a protective effect against insulin resistance and dyslipidemia [5,6]. Regional FM distribution differs physiologically between the two genders and may change in some chronic diseases, such as chronic obstructive pulmonary disease, kidney failure, and diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…In the literature, the trunk/leg ratio (TLR) has been proposed as a marker of lipodystrophy in HIV patients [9,10], and it correlates with insulin resistance and dyslipidemia [5]. The FM of the trunk (FM-tr) and of the legs (FM-legs), and their ratio (TLR) can be considered in studying FM distribution changes occurring in disease and with aging.…”

Section: Introductionmentioning

confidence: 99%

Trunk and Lower Limb Fat Mass Evaluated by Dual-Energy X-Ray Absorptiometry in a 20- to 80-Year-Old Healthy Italian Population

Coin¹,

Ruggiero²,

Giannini

et al. 2012

Ann Nutr Metab

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Background and Aims: Global fat mass distribution seems to correlate with different levels of cardio-metabolic risk; centrally distributed fat carries a high risk of cardiovascular disease, while lower limb adiposity may have a protective effect against insulin resistance. Reference data regarding body composition have already been published for the Italian population; the aim of this study was to add reference values for trunk and lower limb fat mass, and their ratio (TLR), developing percentile distributions for age brackets between 20 and 80 years. Methods: A retrospective analysis of a multicenter, cross-sectional study was conducted and 1,570 healthy Italian adults (1,241 females and 329 males) were selected. The regional fat mass, measured by dual-energy X-ray absorptiometry total body scan, was analyzed and the TLR was calculated. Results: In both genders we observed higher trunk fat mass values in older subjects against a smaller difference in BMI values. The leg fat mass was higher in old men, while it was similar in women at different ages. The TLR values in older subjects doubled those of younger subjects in both genders (62% in males and 71% in females). Conclusions: The identified ranges for trunk, leg fat mass, and TLR may be used as reference values to describe the global fat mass distribution in healthy individuals and to identify states of altered body fat distribution.

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“…28 Similarly, a Norwegian study has reported that the accumulation of trunk fat increases the incidence of insulin resistance and dyslipidemia. 29 Therefore, the significant reductions in trunk fat in the Maté group observed in this study suggest that long-term ingestion of Maté may also improve dyslipidemia.…”

Section: Discussionmentioning

confidence: 56%

The Effect of Maté Extract on Body Weight and Fat Reduction in Obese Women: A Randomized Placebo-controlled Clinical Trial

Jung

Hur

2016

KJO

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Background: This study was performed to investigate the effects of Maté extract on body weight and fat content in obese women [25.0 kg/m 2 ≤ body mass index (BMI) < 30 kg/m 2 ] aged 20-65 years after 6 weeks of its administration. Methods: The randomized, double-blind, placebo-controlled study was conducted in 33 women. Participants took the supplement, either 2 Maté tablets or 2 placebo tablets, twice daily before meals for 6 weeks. Body weight, body mass index (BMI), waist circumference (WC), and various safety parameters were monitored. Body composition was measured by dual-energy X-ray absorptiometry at baseline and after 6 weeks. Results: Average body weight and BMI did not show any significant changes; however, trunk fat percentage significantly decreased in the Maté group compared to that in the placebo group (-1.24% vs -0.16%, P= 0.03). In the Maté group, the body fat percentages showed a tendency to decrease. All safety parameters were within normal ranges in both groups. Two participants, one from each group, reported nausea during the study. Conclusion: Maté extract significantly reduced trunk fat in obese women after 6 weeks, which indicates that it could improve abdominal fat mass. Furthermore, the supplement is safe and well tolerated.

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Insulin resistance and dyslipidaemia in obese premenopausal and postmenopausal women matched for leg/trunk fat mass ratio

Abstract: FM distribution is the major determinant of insulin resistance and dyslipidaemia, with only minor roles for menopausal status, age as such and age- related changes in hormonal factors in the regulation of glucose and lipid metabolism.

Cited by 12 publications

References 40 publications

Metabolic or bariatric surgery? Long-term effects of malabsorptive vs restrictive bariatric techniques on body composition and cardiometabolic risk factors

Metabolic or bariatric surgery? Long-term effects of malabsorptive vs restrictive bariatric techniques on body composition and cardiometabolic risk factors

Trunk and Lower Limb Fat Mass Evaluated by Dual-Energy X-Ray Absorptiometry in a 20- to 80-Year-Old Healthy Italian Population

The Effect of Maté Extract on Body Weight and Fat Reduction in Obese Women: A Randomized Placebo-controlled Clinical Trial

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