Insulin resistance and hyperandrogenism have no substantive association with birth weight in adolescents with polycystic ovary syndrome

Fulghesu, Anna Maria; Manca, Roberta; Loi, Sara; Fruzzetti, Franca

doi:10.1016/j.fertnstert.2014.12.109

Cited by 12 publications

(9 citation statements)

References 31 publications

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“…Sixteen studies were conducted in European populations (two in France, 10,11 one in Finland, 12 one in Germany, 13 two in Greece, 14,15 one in Italy, 16 one in Portugal, 17 one in Romania, 18 one in Slovakia, 19 one in Spain, 20 three in Sweden, [21][22][23] one in the Netherlands, 24 and one in Turkey 25 ), six in American populations (three in Brazil, [26][27][28] two in Mexico, 29,30 and one in the United States 31 ), and six in Asian populations (three in China, [32][33][34] one in Japan, 35 one in Korea, 36 and one in Taiwan 37 ). Regarding the study designs, we found 17 cross-sectional studies, [14][15][16][17][18][19]22,[25][26][27]29,30,[32][33][34][35]37 9 prospective cohorts, [10][11]…”

Section: Resultsmentioning

confidence: 99%

“…31 Seven studies used a matched design. 12,15,16,21,32,33,37 Ten out of the 28 studies had small sample sizes 10,11,15,19,20,22,25,30,33,35 (<100 participants), 9 had medium sample sizes 12,13,16,17,21,24,26,34 (100-500 participants), and another 9 had large sample sizes 14,18,23,27,28,36,37 (>500 participants).…”

Section: Resultsmentioning

confidence: 99%

“…Participants' age ranged from 2 to 17 years old at the time of outcome assessment. Several studies reported p values adjusted for age, 16,17 sex, 10,36 or both. 12,15,20,28,30,34 Other confounders frequently accounted for were body mass index (BMI) 15,21,22,28,[33][34][35] and pubertal status.…”

Section: Resultsmentioning

confidence: 99%

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Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta‐analysis

et al. 2021

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In recent decades, the incidence of type 2 diabetes (T2D) has increased dramatically in children and adolescents, posing a real public health problem. Beyond unhealthy diets and sedentary lifestyles, growing evidence suggests that some perinatal factors, such as low birth weight (LBW), are associated with higher risk of T2D in adulthood.In this regard, it remains unclear whether the increased risk is already present in childhood and adolescence. We conducted a systematic review and meta-analysis to clarify the association of LBW or being small for gestational age (SGA) with insulin resistance in childhood and adolescence. The systematic review resulted in 28 individual studies, and those with the same outcome were included within two random-effects meta-analyses. Compared with children or adolescents born with adequate size for gestational age, those SGA had 2.33-fold higher risk of T2D (95% confidence interval [CI]: 1.05-5.17). Furthermore, LBW and being SGA were associated with 0.20 higher mean homeostasis model assessment of insulin resistance (HOMA-IR) values (95% CI: 0.02-0.38). Given the high prevalence of preterm babies, from a population perspective, these results may be of great importance as they point to the existence of a potentially vulnerable subgroup of children and adolescents that could benefit from screening tests and early preventive strategies.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta‐analysis

et al. 2021

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“…Elevated AMH can lead to an increase in LH through gonadotropin-releasing hormone activation, which in turn promotes the production and secretion of ovarian androgens by theca cells in the presence of insulin [ 27 ]. Hyperandrogenism can also modulate insulin sensitivity, which may be the key to why insulin resistance was found to be associated with AMH [ 28 , 29 ]. Jie et al found that PCOS with hyperandrogenism is associated with a high rate of nonalcoholic fatty liver disease, which can reduce the secretion of SHBG and in turn lead to a higher FAI [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

AMH Is a Good Predictor of Metabolic Risk in Women with PCOS: A Cross-Sectional Study

Lin

et al. 2021

International Journal of Endocrinology

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Objective. The relationship between metabolic risk and ovarian function is ambiguous. This retrospective study analyzed the medical records of 461 PCOS patients collected between January 2019 and June 2020 to investigate the relationship between serum anti-Müllerian hormone (AMH) and parameters of metabolic risk in the population with polycystic ovary syndrome (PCOS). Methods. A total of 461 PCOS patients aged 20–40 years were included and stratified into four groups according to the AMH level. The association between AMH and the parameters related to metabolic risk in these groups was compared, and the discrepancies were further explored. Binary logistic regression was performed to examine the risk factors of HOMA-IR. The values of AMH that best predicted the risk of HOMA-IR were also analyzed by ROC curves. Results. AMH was negatively associated with HOMA-IR (odds ratio (OR) −0.279, 95% confidence interval (CI) −0.36 to −0.20), fasting insulin (OR −0.282, 95% CI −0.36 to −0.20), 1-hour postprandial insulin (OR −0.184, 95% CI −0.28 to −0.11), 2-hour postprandial insulin (−0.180, 95%CI −0.28 to −0.11), 3-hour postprandial insulin (OR −0.198, 95% CI –0.30 to −0.13), waist-hip ratio (OR −0.235, 95% CI −0.31 to −0.14), and body mass index (OR −0.350, 95% CI −0.43 to −0.27). There was no statistically significant relationship between blood pressure, serum glucose profile, or lipid levels and AMH. Binary logistic regression showed that AMH protected against the occurrence of PCOS patients (OR: 0.835, 0.776, and 0.898). For the prediction of HOMA-IR, AMH had an AUC-ROC of 0.704 (95% CI 0.652–0.755) with a cutoff value of 7.81 mmol/L, a sensitivity of 70.3%, and a specificity of 70.1%. Conclusions. Higher AMH levels were significantly associated with a lower insulin profile and might be a useful predictor for HOMA-IR in PCOS patients.

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“…On the other hand, a lower ponderal index and high birth weight also have each been associated with an increase in PCOSrelated symptoms [15,16]. While other studies have failed to establish an association between PCOS and birth weight [17,18].…”

Section: Introductionmentioning

confidence: 99%

Developmental origins of polycystic ovary syndrome (PCOS), a case control study comparing birth weight in women with PCOS and control group

Sadrzadeh

Painter

Lambalk

2016

Gynecological Endocrinology

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Evidence from various epidemiological studies and experimental animal studies has linked adverse intrauterine circumstances with health problems in adult life. This field of investigation is known as Developmental Origins of Health and Disease (DOHaD). Studies investigating the relation between developing polycystic ovary syndrome (PCOS) in adulthood and birth weight have yielded inconsistent results: PCOS is described more often in women with low birth weight and high birth weight, while other studies have failed to establish any relation. In this retrospective case-control study, we evaluated whether women diagnosed with PCOS had lower birth weight compared to women with a regular menstrual cycle (controls). Binary logistic regression models were used to analyze the data and correct for known confounders. About 65 women with PCOS and 96 controls were recruited for this purpose. The average birth weight of PCOS women (3357 g) did not differ from the average birth weight of controls (3409 g). Mean age at menarche differed significantly between groups, 13.7 years and 12.8 years (p ¼ 0.006), respectively, for PCOS women and controls. In conclusion, we could not confirm the effect of adverse intrauterine conditions, reflected in birth weight, on developing PCOS.

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Insulin resistance and hyperandrogenism have no substantive association with birth weight in adolescents with polycystic ovary syndrome

Cited by 12 publications

References 31 publications

Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta‐analysis

Low birth weight and small for gestational age are associated with complications of childhood and adolescence obesity: Systematic review and meta‐analysis

AMH Is a Good Predictor of Metabolic Risk in Women with PCOS: A Cross-Sectional Study

Developmental origins of polycystic ovary syndrome (PCOS), a case control study comparing birth weight in women with PCOS and control group

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