Insulin resistance and hyperinsulinaemia in the development and progression of cancer

Godsland, Ian F.

doi:10.1042/cs20090399

Cited by 196 publications

(171 citation statements)

References 197 publications

(179 reference statements)

Supporting

Mentioning

163

Contrasting

Unclassified

Order By: Relevance

“…This illustrates the importance of the IGF signaling pathway in obesity-related breast cancer. Overall, IGF-1 has been linked with cell survival (anti-apoptosis) in addition to tumor cell growth (Yu and Rohan, 2000;Godsland, 2010). This occurs primarily through activation of PI3K/Akt and MAPK/p38 pathways (Sung et al, 2011).…”

Section: Obesitymentioning

confidence: 99%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

show abstract

Section: Obesitymentioning

confidence: 99%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Weight gain is associated with hyperinsulinemia and insulin resistance which increases circulating IGF-I concentrations. 30 IGF-I is known to increase the proliferation of both androgen-dependent and androgenindependent prostate epithelial cells. 31 In a recent metaanalysis of 12 prospective studies, high IGF-1 concentrations have been demonstrated to increase the risk of prostate cancer.…”

Section: Cancer Epidemiology 870mentioning

confidence: 99%

Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies

Chen

Shi

et al. 2015

Intl Journal of Cancer

View full text Add to dashboard Cite

The association between adult weight gain and risk of prostate cancer has not been widely studied and the findings are inconsistent. Therefore, our study aimed to investigate the association between adult weight gain and risk of prostate cancer. PubMed, Embase and Web of Science databases were searched for relevant studies published before September 2014 using terms related to weight gain and prostate cancer. Summary estimates were obtained using the random-effects model. Doseresponse meta-analysis, sensitivity analysis and publication bias tests were performed. Nine studies involving 497,634 participants and 22,338 cancer cases were included. For total prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >30 kg. For low-intermediate-risk prostate cancer, a positive relationship with adult weight gain was observed until weight gain increased to >15 kg. For high-risk prostate cancer, we observed a positive linear relationship with adult weight gain with a relative risk (RR) of 1.02 [95% confidence interval (CI) 1.00-1.04] for every 5-kg increase. For fatal prostate cancer, we observed a positive linear relationship with adult weight gain with an RR of 1.12 (95% CI: 1.05-1.19) for every 5-kg increase. There is evidence that adult weight gain is associated with an increased risk of highrisk and fatal prostate cancer, but only low weight gain is positively associated with low-intermediate-risk prostate cancer.Prostate cancer is the most common cancer in men of the developed countries and the second most common cancer worldwide in 2008.1 The increase in prostate cancer incidence and mortality observed in immigrants from low-risk to highrisk countries suggests that lifestyle and dietary factors play an important role in the etiology of prostate cancer. 2,3 Excess body weight comprehensively reflects lifestyle and dietary factors, which occurs when the expenditure (i.e., physical activity) is less than the intake (i.e., high-fat diets). Excess body weight, as measured by body mass index (BMI), has been considered a factor for decreased and increased risk of localized and advanced prostate cancer, respectively.4 However, prostate cancer is a disease involving a long process of tumor initiation, promotion and progression; therefore, weight gain during adulthood might be related to subsequent prostate cancer risk. Adult weight gain is a dynamic measure that reflects fluctuations in weight over time, which is thought to be a better measure of adiposity than a static measure of weight such as BMI. 5The association between adult weight gain and prostate cancer risk has not been widely studied and the findings are inconsistent. Some studies showed positive association, 6,7 while other studies showed no associations. [8][9][10][11][12][13][14] A newly published meta-analysis reported that adult weight gain was unrelated to total prostate cancer.15 However, the finding that weight gain might be differentially associated with low-intermediate-and high-risk prostate cancer ha...

show abstract

“…Besides the effects on glucose metabolism, insulin resistance is associated with other conditions like cardiovascular disease [2] and cancer [3], and even predicts mortality [4]. The precise mechanisms that regulate peripheral insulin sensitivity in humans are still not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

et al. 2012

View full text Add to dashboard Cite

Aims/hypothesis Impaired insulin sensitivity is a major factor leading to type 2 diabetes. Animal studies suggest that the brain is involved in the regulation of insulin sensitivity. We investigated whether insulin action in the human brain regulates peripheral insulin sensitivity and examined which brain areas are involved. Methods Insulin and placebo were given intranasally. Plasma glucose, insulin and C-peptide were measured in 103 participants at 0, 30 and 60 min. A subgroup (n012) was also studied with functional MRI, and blood sampling at 0, 30 and 120 min. For each time-point, the HOMA of insulin resistance (HOMA-IR) was calculated as an inverse estimate of peripheral insulin sensitivity.

show abstract

Insulin resistance and hyperinsulinaemia in the development and progression of cancer

Cited by 196 publications

References 197 publications

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Adult weight gain and risk of prostate cancer: A dose–response meta‐analysis of observational studies

Nasal insulin changes peripheral insulin sensitivity simultaneously with altered activity in homeostatic and reward-related human brain regions

Contact Info

Product

Resources

About