Insulin Resistance and Incident Gallbladder Disease in Pregnancy

Ko, Cynthia W.; Beresford, Shirley A.A.; Schulte, Scott J.; Lee, Sum P.

doi:10.1016/j.cgh.2007.10.007

Cited by 38 publications

(19 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Resolution frequently transpires during the post-partum period: sludge disappears in two-thirds; small (<1 cm) gallstones (microlithiasis) vanish in one-third, but definitive gallstones become established in ~5% 75,76. Additional risk factors for stone formation during pregnancy include obesity (prior to the pregnancy), reduced high density lipoprotein (HDL) cholesterol and the metabolic syndrome 76,77…”

Section: Gallstone Diseasementioning

confidence: 99%

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Stinton¹,

Shaffer²

2012

Gut Liver

1,011

783

View full text Add to dashboard Cite

Diseases of the gallbladder are common and costly. The best epidemiological screening method to accurately determine point prevalence of gallstone disease is ultrasonography. Many risk factors for cholesterol gallstone formation are not modifiable such as ethnic background, increasing age, female gender and family history or genetics. Conversely, the modifiable risks for cholesterol gallstones are obesity, rapid weight loss and a sedentary lifestyle. The rising epidemic of obesity and the metabolic syndrome predicts an escalation of cholesterol gallstone frequency. Risk factors for biliary sludge include pregnancy, drugs like ceftiaxone, octreotide and thiazide diuretics, and total parenteral nutrition or fasting. Diseases like cirrhosis, chronic hemolysis and ileal Crohn's disease are risk factors for black pigment stones. Gallstone disease in childhood, once considered rare, has become increasingly recognized with similar risk factors as those in adults, particularly obesity. Gallbladder cancer is uncommon in developed countries. In the U.S., it accounts for only ~ 5,000 cases per year. Elsewhere, high incidence rates occur in North and South American Indians. Other than ethnicity and female gender, additional risk factors for gallbladder cancer include cholelithiasis, advancing age, chronic inflammatory conditions affecting the gallbladder, congenital biliary abnormalities, and diagnostic confusion over gallbladder polyps.

show abstract

Section: Gallstone Diseasementioning

confidence: 99%

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Stinton¹,

Shaffer²

2012

Gut Liver

1,011

783

View full text Add to dashboard Cite

show abstract

“…Ko and colleagues [75] compared 205 women with new gallbladder sludge or stones during pregnancy against 443 controls. Logistic analysis showed that the effect of BMI was attenuated after adjusting for insulin resistance.…”

Section: Case-control Studies Of Habitual Physical Activity and Gallbmentioning

confidence: 99%

Physical Activity and the Biliary Tract in Health and Disease

Shephard

2015

Sports Med

View full text Add to dashboard Cite

show abstract

“…Importantly, oral contraceptives also affect the risk of gallstone formation, pointing at the role of endocrine factors [44], likely mediated by progesterone effects on gallbladder contractility [45]. Additional endocrine changes have since been identified, which also affect the chemical composition of bile and thus promote stone formation [46,47].…”

Section: Etiologymentioning

confidence: 99%

Black Bile of Melancholy or Gallstones of Biliary Colics: Historical Perspectives on Cholelithiasis

Bielefeldt

2014

Dig Dis Sci

View full text Add to dashboard Cite

Barely 130 years after its first description, cholecystectomies are among the most commonly performed surgeries in the USA. The success of this operation with subsequent technical improvements, such as laparoscopic approaches, caused a paradigm shift in the management of gallstone disease. However, symptoms persist in 10-40 % of successfully operated patients. Reviewing monographs, textbooks, and articles published during the last 300 years, several important factors emerge as likely contributors to limited or poor treatment responses. Early on, clinicians recognized that cholelithiasis is quite common and thus often an incidental finding, especially if patients present with vague or atypical symptoms. Consistent with these observations, patients with such atypical symptoms are less likely to benefit from cholecystectomy. Similarly, lasting improvements are more reliably seen in patients with symptoms of presumed biliary origin and documented gallstones compared to individuals without stones, an important point in view of increasing rates of surgery for biliary dyskinesia. While cholelithiasis can cause serious complications, the overall incidence of clinically relevant problems is so low that prophylactic cholecystectomy cannot be justified. This conclusion corresponds to epidemiologic data showing that the rise in elective cholecystectomies decreased hospitalizations due to gallstone disease, but was associated with a higher volume of postoperative complications, ultimately resulting in stable combined mortality due to gallstone disease and its treatment. These trends highlight the tremendous gains in managing gallstone disease, while at the same time reminding us that the tightening rather than expanding indications for cholecystectomy may improve outcomes.

show abstract

Insulin Resistance and Incident Gallbladder Disease in Pregnancy

Abstract: Background and Aims-Insulin resistance is associated with prevalent gallstones, but its effect on initial gallstone formation is not well understood.

Cited by 38 publications

References 30 publications

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Epidemiology of Gallbladder Disease: Cholelithiasis and Cancer

Physical Activity and the Biliary Tract in Health and Disease

Black Bile of Melancholy or Gallstones of Biliary Colics: Historical Perspectives on Cholelithiasis

Contact Info

Product

Resources

About