Insulin resistance and its association with catch‐up growth in <scp>C</scp>hinese children born small for gestational age

Liu, Chunhua; Wu, Bingquan; Lin, Ning; Fang, Xiaoyi

doi:10.1002/oby.21683

Cited by 25 publications

(40 citation statements)

References 31 publications

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“…Preterm birth is also a well-established risk factor for T2D and related cardiometabolic risk factors ( 43 , 44 , 45 ). Moreover, the catch-up growth of SGA children is associated with insulin resistance in childhood ( 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome and risk factors for gestational diabetes

Mustaniemi

Vääräsmäki

Eriksson

et al. 2018

Endocrine Connections

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ObjectiveTo study the roles of self-reported symptoms and/or prior diagnosis of polycystic ovary syndrome (PCOS) and other potential risk factors for gestational diabetes mellitus (GDM) and to clarify whether the screening of GDM in early pregnancy is beneficial for all women with PCOS.DesignThe FinnGeDi multicentre case-control study including 1146 women with singleton pregnancies diagnosed with GDM and 1066 non-diabetic pregnant women. There were 174 women with PCOS (symptoms and/or diagnosis self-reported by a questionnaire) and 1767 women without PCOS (data missing for 271).MethodsThe study population (N = 1941) was divided into four subgroups: GDM + PCOS (N = 105), GDM + non-PCOS (N = 909), non-GDM + PCOS (N = 69), and controls (N = 858). The participants’ characteristics and their parents’ medical histories were compared.ResultsThe prevalence of PCOS was 10.4% among GDM women and 7.4% among non-diabetics (odds ratios (OR) 1.44, 95% CI: 1.05–1.97), but PCOS was not an independent risk for GDM after adjustments for participants’ age and pre-pregnancy BMI (OR 1.07, 95% CI: 0.74–1.54). In a multivariate logistic regression analysis, the most significant parameters associated with GDM were overweight, obesity, age ≥35 years, participant’s mother’s history of GDM, either parent’s history of type 2 diabetes (T2D) and participant’s own preterm birth.ConclusionsThe increased risk of GDM in women with PCOS was related to obesity and increased maternal age rather than to PCOS itself, suggesting that routine early screening of GDM in PCOS women without other risk factors should be reconsidered. Instead, family history of GDM/T2D and own preterm birth were independent risk factors for GDM.

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Section: Discussionmentioning

confidence: 99%

Polycystic ovary syndrome and risk factors for gestational diabetes

Mustaniemi

Vääräsmäki

Eriksson

et al. 2018

Endocrine Connections

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“…Furthermore, most SGA infants will experience catch up growth (CUG) during early childhood, and the patterns of CUG are affected by hypothyroidism and following L-T4 replacement therapy [7,8]. Cianfarani et al discovered higher TSH concentrations in SGA children with blunted CUG, suggesting the intrauterine reprogramming may involve thyroid function, which might affect postnatal growth in turn [9].…”

Section: Introductionmentioning

confidence: 99%

Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns

et al. 2020

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Background: Thyroid hormones play an important role in the normal growth and maturation of the central nervous system. However, few publications addressed the altered thyroid hormone levels in preterm small for gestational age (SGA) newborns. We hypothesized preterm SGA infants have higher thyroid-stimulating hormone (TSH) concentrations than appropriate for gestational age (AGA) ones within the normal range and an increased incidence of thyroid dysfunction. Methods: The study was designed to compare thyroid hormone levels within the normal range and the incidence of thyroid dysfunction in the SGA and AGA groups to test the hypothesis. The medical records of all preterm infants admitted to the neonatal intensive care unit (NICU) at the

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Section: Introductionmentioning

confidence: 99%

Small for Gestational Age is a Risk Factor for Thyroid Dysfunction in Preterm Newborns

Liu

Wang

Guo

et al. 2020

Preprint

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Background Thyroid hormones play an important role in the normal growth and maturation of the central nervous system. However, few publications addressed the altered thyroid hormone levels in preterm small for gestational age (SGA) newborns. We hypothesized preterm SGA infants have higher thyroid-stimulating hormone (TSH) concentrations than appropriate for gestational age (AGA) ones within the normal range and an increased incidence of thyroid dysfunction. Methods The study was designed to compare thyroid hormone levels within the normal range and the incidence of thyroid dysfunction in the SGA and AGA groups to test the hypothesis. Blood samples were collected between 72 and 96 hours of life and analyzed with TSH, free thyroxine (FT4) and free triiodothyronine (FT3) assays. Thyroid function test (TFT) results, and neonatal demographic and clinical factors were analyzed to identify the associations between SGA birth and altered thyroid concentrations and thyroid dysfunction. Results TSH and FT4 concentrations were significantly higher in the SGA group than the AGA group ((4.89(interquartile range (IQR): 2.62~7.59) vs. 3.15(IQR: 1.86~5.42) mU/L, p=0.015), and (18.64±4.39 vs. 17.40±3.70 pmol/L, p=0.037), respectively). The higher TSH levels were associated with being SGA or Z-score of birth weight (BW) for GA after adjusting for potential confounders (( β SGA =1.28 (95% confidence interval (CI) 0.45~2.12), p=0.003) or ( β Z-score =-0.25 (95%CI -0.48~-0.03), p=0.028), respectively). However, we did not find a significant association between SGA birth and altered FT4 concentrations. Furthermore, compared with the AGA group, the SGA group presented an increased incidence of transient hypothyroxinemia with delayed TSH elevation (dTSHe) (odds ratio (OR) =8.75(95%CI 0.71~78.02)), a higher percentage receiving levothyroxine (L-T4) therapy (OR=1.80 (95%CI 0.98~3.21)), and a higher rate of follow-up within the first 6 months of life (OR=1.82 (95%CI 0.93~3.39)). Conclusions Preterm SGA newborns had significantly higher TSH concentrations within the normal range and an increased incidence of thyroid dysfunction. The SGA newborns with these features should be closely followed up with periodical TFTs and endocrinologic evaluation.

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Insulin resistance and its association with catch‐up growth in Chinese children born small for gestational age

Cited by 25 publications

References 31 publications

Polycystic ovary syndrome and risk factors for gestational diabetes

Polycystic ovary syndrome and risk factors for gestational diabetes

Small for gestational age is a risk factor for thyroid dysfunction in preterm newborns

Small for Gestational Age is a Risk Factor for Thyroid Dysfunction in Preterm Newborns

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