Insulin resistance and its relationship with high molecular weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history of polycystic ovary syndrome

Cankaya, Sevil; Demır, Berfu; Aksakal, Sezin Ertürk; Dilbaz, Berna; Demirtaş, Canan; Göktolga, Ümit

doi:10.1016/j.fertnstert.2014.05.032

Cited by 28 publications

(15 citation statements)

References 38 publications

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“…In a study of nonobese adolescents with PCOS, HMW adiponectin levels were negatively correlated with IR. 57 In a Chinese study of 10 women with PCOS and 10 BMI-matched normoovulatory controls undergoing IVF, the levels of total adiponectin and the HMW adiponectin were decreased in the follicular fluid and serum of the women with PCOS. 45 Future research in PCOS should preferably focus on HMW adiponectin in addition to total adiponectin 18 (►Table 1).…”

Section: Adipokines the Link Between Adipose Tissue Dysfunction And mentioning

confidence: 99%

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

et al. 2015

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Polycystic ovary syndrome (PCOS) has become increasingly common over recent years and is associated with reproductive features as well as cardiometabolic risk factors, including visceral obesity, dyslipidemia and impaired glucose homeostasis, and potentially cardiovascular disease. Emerging evidence suggests that these long-term metabolic effects are linked to a low-grade chronic inflammatory state with the triad of hyperinsulinemia, hyperandrogenism, and low-grade inflammation acting together in a vicious cycle in the pathophysiology of PCOS. Dysregulation of the sympathetic nervous system may also act as an important component, potentially creating a tetrad in the pathophysiology of PCOS. The aim of this review is to examine the role of chronic inflammation and the sympathetic nervous system in the development of obesity and PCOS and review potential therapeutic options to alleviate low-grade inflammation in this setting.

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Section: Adipokines the Link Between Adipose Tissue Dysfunction And mentioning

confidence: 99%

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

et al. 2015

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“…By promoting visceral adiposity (75), androgens exert a direct and inverse effect on adipokines production (76,77,78). Adiponectin has a protective, antisteatotic, antiinflammatory, antiapoptotic and consequent antifibrotic effect on hepatocytes (79,80).…”

Section: Molecular Basis Including Endocrine Disruptorsmentioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease

Macut

Božić-Antić

Bjekić-Macut

et al. 2017

European Journal of Endocrinology

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Polycystic ovary syndrome (PCOS) is a frequent endocrine disease in women, with a number of metabolic and reproductive consequences. Obesity, insulin resistance (IR) and type 2 diabetes are prominent metabolic characteristics of PCOS and common factors affecting liver function and generating nonalcoholic fatty liver disease (NAFLD). Multiple genes involved in the synthesis of androgens, cytokines and IR, as well as acquired factors, such as endocrine disruptors, could associate the etiopathogenesis of PCOS and NAFLD. Besides the high prevalence of PCOS in general population, NAFLD was shown to be a frequent condition in transition periods, such as adolescence and menopause. Although liver biopsy is considered to be the gold standard for diagnosing liver damage, its routine use in such a prevalent condition as PCOS can be related to a higher rate of complications. Therefore, it is necessary to be able to diagnose NAFLD using simple and reliable surrogate markers. Recently, fatty liver index and NAFLD fatty liver score analyzed in large cohorts of PCOS women have been shown as accurate markers of liver damage in this metabolically vulnerable population. Lifestyle changes are still the mainstay of the management of NAFLD in PCOS, although prospective randomized controlled clinical studies remain a priority in the field. With regard to medications, metformin may be the drug of choice for treating PCOS patients with NAFLD when pharmacologic therapy is considered. Liraglutide use in obese PCOS has shown favorable effects on the predictors of liver fibrosis. In this review, we aim to summarize the influence of the common risk factors and to discuss the diagnostic approaches and management options for NAFLD in patients with PCOS.

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“…HMW adiponectin has been measured using a variety of techniques. Although most human studies currently use a commercial enzyme-linked immunosorbent assay (ELISA) to measure this form of adiponectin, other techniques such as immunodiffusion, size separation techniques (sucrose gradient, gel electrophoresis, and so forth) followed by Western blot analysis have also been used [18][19][20][21]. A feline compatible ELISA for measuring HMW is not currently available, and the sucrose gradient and/or Western blot technique has been used by some feline diabetes researchers [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Relationship of adiponectin and its multimers to metabolic indices in cats during weight change

Witzel

Kirk

Kania

et al. 2015

Domestic Animal Endocrinology

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Insulin resistance and its relationship with high molecular weight adiponectin in adolescents with polycystic ovary syndrome and a maternal history of polycystic ovary syndrome

Cited by 28 publications

References 38 publications

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

The Emerging Role of Chronic Low-Grade Inflammation in the Pathophysiology of Polycystic Ovary Syndrome

MANAGEMENT OF ENDOCRINE DISEASE: Polycystic ovary syndrome and nonalcoholic fatty liver disease

Relationship of adiponectin and its multimers to metabolic indices in cats during weight change

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