Insulin resistance and oxidative marker in women with PCOS

Bannigida, Doddappa M; Nayak, B. Shivananda; Vijayaraghavan, R.

doi:10.1080/13813455.2018.1499120

Cited by 89 publications

(53 citation statements)

References 22 publications

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“…The biological effectivity can be monitored through periodic measurement of e.g. malondialdehyde in urine as a biomarker of oxidative stress and of the risk of cancer as well as of cardiovascular disease [35]. Glycosylated haemoglobin A1c and C-peptide concentration in blood [36] can serve as measures of glucose metabolism and insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

Nutraceutical Treatment of Patients with Polycystic Ovary Syndrome

Comhaire¹,

Decleer²

2021

OJOG

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Polycystic Ovary Syndrome (PCOS) is a common cause of infertility, requiring antioestrogen and, possibly, gonadotropin treatment for the induction of ovulation. However, patients suffering from this disease need long-term treatment since PCOS is associated with an increased risk of metabolic syndrome, hyperinsulinemia, oxidative stress, inflammation, cardiovascular disease, and cancer. Allopathic treatment includes the continuous use of oral contraceptives, preferentially with complementary anti-androgen activity, and metformin. However, these treatments only partially correct all aspects of the disease, while carrying potential adverse effects per se. Complementary and alternative medicine (CAM) offers opportunities for treatment through the use of nutraceuticals containing plant extracts, minerals, and vitamins with antioxidant, anti-inflammatory, and adaptogen capacity, as well as for correcting insulin resistance. Here we justify the formulation of the nutraceutical QALY® (Jona Pharma, Elversele, Belgium) that is composed of Ubiquinone Q10, the vitamins B9 and B12, the salts of zinc and selenium, the biomass of Haematococcus pluvialis, and the extracts of Mediterranean pine bark and of Rhodiola rosea. This can be complemented by phytotherapy with the extract of Momordica charantia plus alfa lipoic acid (Momordica plus®).

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Section: Discussionmentioning

confidence: 99%

Nutraceutical Treatment of Patients with Polycystic Ovary Syndrome

Comhaire¹,

Decleer²

2021

OJOG

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“…Studies have shown that PCOS is associated with hyperinsulinemia and oxidative stress [27][28][29]. Since afamin is known as an E-binding protein [15], and vitamin E relates to the non-enzymatic antioxidants group, afamin may be a marker of vitamin E-related oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Investigating the relationship of serum levels of afamin and interleukin-10 with insulin resistance in infertile women with polycystic ovary syndrome

Gürbüz¹,

Gökmen²,

Bör³

et al. 2021

Journal of Surgery and Medicine

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“…Oxidative stress is related to the pathogenesis of many diseases, including cardiovascular disease, cancer, and neurodegenerative diseases [16,17]. The presence of an oxidative stress state has also been reported in many female reproductive disorders, such as PCOS and preeclampsia (PE) [18,19]. Oxidative stress occurs mainly from an imbalance between ROS production and the antioxidant defence system, and UA also seems to be involved in this process.…”

Section: Uric Acid In Oxidative Stress and Mitochondrial Dysfunctionmentioning

confidence: 99%

Uric acid participating in female reproductive disorders: a review

Yang

et al. 2021

Reprod Biol Endocrinol

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Uric acid (UA) is the end metabolic product of purine metabolism. Early on, UA was considered to be a metabolite with a certain antioxidant capacity. As research has progressed, other properties of UA have been explored, and its association with many diseases has been found. The association between UA and kidney disease and cardiovascular disease is well established; however, there is still a paucity of reviews on the association between UA and the female reproductive system. An increasing number of epidemiological studies have shown elevated serum UA levels in patients with polycystic ovary syndrome (PCOS), endometriosis, etc. Additionally, serum UA can be used as a predictor of pregnancy complications and adverse foetal outcomes. An increasing number of animal experiments and clinical studies have revealed possible mechanisms related to the involvement of UA in certain female reproductive disorders: oxidative stress, chronic inflammation, mitochondrial dysfunction, etc. This article reviews the current mainstream mechanisms regarding the pathogenesis of UA and the role of UA in certain specific female reproductive disorders (direct involvement in the development of certain diseases or enhancement of other risk factors) in the hope of contributing to clinical prevention, diagnosis, treatment and improvement in prognosis.

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Insulin resistance and oxidative marker in women with PCOS

Cited by 89 publications

References 22 publications

Nutraceutical Treatment of Patients with Polycystic Ovary Syndrome

Nutraceutical Treatment of Patients with Polycystic Ovary Syndrome

Investigating the relationship of serum levels of afamin and interleukin-10 with insulin resistance in infertile women with polycystic ovary syndrome

Uric acid participating in female reproductive disorders: a review

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