Insulin resistance and serum levels of adipokines in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Kuo, Che Yuan; Tsai, Tsung Yu; Huang, Yu Chen

doi:10.1177/0961203320935185

Cited by 20 publications

(11 citation statements)

References 37 publications

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“… 24 The causes of atherogenic dyslipidaemia in SLE are diverse, including insulin resistance and the inability of insulin to stimulate glucose metabolism. 25 Insulin resistance hinders the lipolysis and storage of fatty acids in adipocytes and alters the metabolic pathway dependent on PI 3 kinases which, among other functions, contribute to the degradation of apolipoprotein B. As a result of the massive supply of fatty acids and the defect in the degradation of apolipoprotein B, hypertriglyceridaemia and the atherogenic lipoprotein phenotype appear.…”

Section: Discussionmentioning

confidence: 99%

Study of common hypertriglyceridaemia genetic variants and subclinical atherosclerosis in a group of women with SLE and a control group

et al. 2022

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ObjectiveSLE is associated with increased cardiovascular risk (CVR). High serum concentrations of triglyceride-rich lipoproteins and apolipoprotein B-rich particles constitute the characteristic dyslipidaemia of SLE.MethodsA cross-sectional study was conducted to study the relationship between genetic variants involved in polygenic hypertriglyceridaemia, subclinical atherosclerosis and lipoprotein abnormalities. 73 women with SLE and 73 control women age-matched with the case group were recruited (age range 30–75 years). Serum analysis, subclinical atherosclerosis screening studies for the detection of plaque, and genetic analysis of the APOE, ZPR1, APOA5 and GCKR genes were performed.ResultsTriglyceride concentrations and the prevalence of hypertension, dyslipidaemia and carotid atherosclerosis were higher in women with SLE than in the control group. Multivariate logistic regression showed that CC homozygosity for the GCKR rs1260326 gene (OR=0.111, 95% CI 0.015 to 0.804, p=0.030) and an increase of 1 mmol/L in triglyceride concentrations were associated with a greater risk of carotid plaque in women with SLE (OR=7.576, 95% CI 2.415 to 23.767, p=0.001).ConclusionsGCKR CC homozygosity (rs1260326) and serum triglyceride concentrations are independently associated with subclinical carotid atherosclerosis in women with SLE. Subclinical carotid atherosclerosis is also more prevalent in these women compared with the control group. The study of GCKR rs1260326 gene variants may contribute to more precise assessment of CVR and modulation of the intensity of lipid-lowering treatment in patients with SLE.

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Section: Discussionmentioning

confidence: 99%

Study of common hypertriglyceridaemia genetic variants and subclinical atherosclerosis in a group of women with SLE and a control group

et al. 2022

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“…This is attributed to the inflammatory nature of SLE and the use of corticosteroids as one of the important therapeutic modalities [ 57 - 58 ]. Kuo et al performed a systemic review and meta-analysis in 2020 with a total population of 4460 SLE patients who showed, when compared to controls, to have greater values of homeostasis model assessment for insulin resistance (HOMA-IR), standardized mean difference (SMD) of 0.425; 95% confidence interval (CI) 0.156-0.693; I2=93.8%, and higher levels of adiponectin (SMD=0.547; 95% CI 0.219-0.874; I2=90.1%), leptin (SMD=0.843; 95% CI 0.454-1.231; I2=94.4%), and resistin (SMD=0.856; 95% CI 0.199-1.513; I2=96.6%) with an association between serum resistin and SLE activity [ 59 ].…”

Section: Reviewmentioning

confidence: 99%

Cardiovascular Complications in Systemic Lupus Erythematosus

Alghareeb¹,

Hussain²,

Maheshwari³

et al. 2022

Cureus

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Systemic lupus erythematosus (SLE) is an auto-immune disease of a relapsing-remitting nature that can cause multiorgan damage depending on several factors, mainly the disease activity. Young age women are the most likely to be affected by the disease and the female-to-male prevalence ratio is approximately 1:10. As the number of SLE patients has been increasing in the last few decades, the annual number of deaths due to the disease and its complications has increased as well, and one of the most important systems to which high mortality is attributed is the cardiovascular system, leading to premature atherosclerosis and other events such as endocarditis and valve disease. In addition to the classical cardiovascular risk factors, studies have found a positive correlation between SLE and other cardio-harmful diseases such as metabolic syndrome and dyslipidemia. Moreover, some of the medications used in the treatment of SLE place a heavy burden on the heart. The article reviews the shared pathophysiology of SLE and cardiovascular disease along with the most common SLE-associated cardiac risks, events, and management.

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“…Recently, a possible association between systemic lupus erythematosus (SLE) and high rates of insulin resistance (IR) measured by the Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) insulin resistance index 1,2 and metabolic syndrome (MetS) 3 has become a topic of interest. IR, defined as insulin-sensitive tissues decreased sensitivity or receptivity to insulin 4 , has been shown to be an independent risk factor for type 2 diabetes mellitus (T2DM) 5 , and can be present for years before the appearance of any changes in glycemic control.…”

Section: Introductionmentioning

confidence: 99%

Insulin resistance metabolomic profile in non-diabetic women with systemic lupus erythematosus

Mendoza‐Pinto¹,

Garcı́a-Carrasco²,

Méndez‐Martínez³

et al. 2023

GMM

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Introduction:Patients with systemic lupus erythematosus (SLE) have a higher prevalence of insulin resistance (IR) and metabolic syndrome (MetS) than controls. Objective: To evaluate IR in non-diabetic women with SLE by means of biomarkers using high-throughput metabolomic techniques. Method: Cross-sectional study in patients with SLE. A metabolomic approach was employed using ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry. MetS was evaluated according to NCEP-ATP III criteria. Results: Seventy patients with SLE were included, out of whom 45 (64.2%) and 27 (38.5%) had IR and MetS, respectively. Patients with IR had a higher body mass index and hypertension more often than those without IR. Chronic damage and disease activity were not related to IR. A Quantose-IR score ≥ 63 was more common in patients with MetS (81.5 vs. 53.5%; p = 0.02). Quantose-IR score was also correlated with the number of criteria for MetS (r: 0.35; p = 0.003). Conclusions: In non-diabetic women with SLE, the prevalence of IR based on Quantose-IR score was 64.2%.

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Insulin resistance and serum levels of adipokines in patients with systemic lupus erythematosus: a systematic review and meta-analysis

Cited by 20 publications

References 37 publications

Study of common hypertriglyceridaemia genetic variants and subclinical atherosclerosis in a group of women with SLE and a control group

Study of common hypertriglyceridaemia genetic variants and subclinical atherosclerosis in a group of women with SLE and a control group

Cardiovascular Complications in Systemic Lupus Erythematosus

Insulin resistance metabolomic profile in non-diabetic women with systemic lupus erythematosus

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