Insulin Resistance and the Transcription of the Glucose-6-Phosphatase Gene in Newborn Dogs

Reference intervals and age‐related changes for venous biochemical, hematological, electrolytic, and blood gas variables using a point of care analyzer in 68 puppies

“…Studies in metabolic adaptations at birth in both humans and puppies reveal that in the fasted neonate, the liver is capable of maintaining blood glucose concentrations through glycogenolysis and gluconeogenesis. This mechanism may account for neonatal hyperglycemia, which is due to a relative insulin resistance or increased glucagon concentrations in this early postnatal period. Measured rates of glucose oxidation in fasted neonates account for supplying roughly 70% of the energy needs of the brain.…”