Insulin Resistance as a Risk Factor for Gallbladder Stone Formation in Korean Postmenopausal Women

Abstract

Background/AimsThe objective of this study was to determine whether insulin resistance is associated with gallbladder stone formation in Korean women based on menopausal status.MethodsThe study included 4,125 consecutive Korean subjects (30-79 years of age). Subjects who had a medical history of diabetes, hypertension, dyslipidemia, other cardiovascular disorders, or hormone replacement therapy were excluded. The women were subdivided into two groups according to their menopausal status.ResultsAnalysis of premenopausal women showed no significant differences in the homeostasis model of assessment-insulin resistance (HOMA-IR) index between the two groups in terms of gallstone disease. The associations between the occurrence of gallbladder stones and age, obesity, abdominal obesity, hyperinsulinemia, and high HOMA-IR index were statistically significant in the analysis with postmenopausal women. In a multiple logistic regression analysis, low high density lipoprotein-cholesterol was an independent predictor of gallbladder stone formation in premenopausal women. However, the multiple logistic regression analysis also showed that age and HOMA-IR were significantly associated with gallbladder stone formation in postmenopausal women. In an additional analysis stratified by obesity, insulin resistance was a significant risk factor for gallbladder stone formation only in the abdominally obese premenopausal group.ConclusionsInsulin resistance may be associated with gallbladder stone formation in Korean postmenopausal women with abdominal obesity.

The Effect of Obesity on Co-Existence of Umbilical Hernia and Metabolic Syndrome in Patients with Cholelithiasis

“…Yük-sek açlık glukoz düzeyleri hem karaciğerden safra asidi salgı-lanmasını hem de safra kesesinin safra sekresyonu için gerekli kontraksiyonunu inhibe etmektedir. Böylece kolesterol taşı nü-vesi oluşmakta veya oluşan nüveler üzerinde kolesterol ve safra asitleri tabakası artmaktadır [11]. Hiperglisemi safra kesesi motilitesini etkilediği gibi kolelitiazis oluşumunu ve safra kesesi mukus sekresyonunu da etkilemektedir [19][20].…”

“…Ülkemizde MS görülme sıklığı, erkeklerde %28, kadınlarda ise %40 gibi oldukça yüksek değerlerdedir [3]. Çalışmalar MS'yi kolelitiazis için bir risk faktörü olarak öngörmektedir [9][10][11]. Umbilikal herniler, paraumbilikal herniler ve epigastrik herniler tüm karın duvarı hernilerinin %10'luk kısmını oluşturur [12].…”

Polymorphisms in UGT1A1 Gene Predispose South Indians to Pigmentous Gallstones

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Evaluation of daily energy expenditure and health-related physical fitness parameters in patients with cholelithiasis

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