Insulin Resistance but Not Visceral Adiposity Index Is Associated with Liver Fibrosis in Nondiabetic Subjects with Nonalcoholic Fatty Liver Disease

Erçin, Cemal Nuri; Doğru, Teoman; Genç, Halil; Çelebi, Gürkan; Aslan, Fatih; Gürel, Hasan; Kara, Muammer; Sertoğlu, Erdim; Tapan, Serkan; Bağcı, Sait; Rizzo, Manfredi; Sönmez, Alper

doi:10.1089/met.2015.0018

Cited by 37 publications

(28 citation statements)

References 36 publications

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“…However, there is some controversy regarding of the association between VAI and NAFLD. In recent two reports, the researchers found that VAI was associated with IR but not with steatosis in patients with NAFLD proven by liver biopsy (37,38), meaning VAI may not be a good tool to predict NAFLD. In the current study, we also did not find the significant difference of VAI between two groups with or without HS.…”

Section: Discussionmentioning

confidence: 99%

Lipid accumulation product independently correlate with hepatic steatosis quantified by controlled attenuation parameter in women with polycystic ovary syndrome

Zheng

Tong

Dong

et al. 2020

Endocrine Connections

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Objective To explore the independent associations of the new adiposity indices lipid accumulation product (LAP) index, visceral adiposity index (VAI), and product of triglycerides and glucose (TyG) with the risks of hepatic steatosis (HS) in women with polycystic ovary syndrome (PCOS). Design This is a cross-sectional study with 101 women with PCOS undergoing controlled attenuation parameter (CAP) measurement who were recruited from November 2018 to August 2019. Multivariable logistic regression analysis was performed to determine the associations of adiposity indices with HS. Result(s) Among the 101 PCOS patients, the prevalence rate of HS was 70.3%. The PCOS patients with HS have higher percentage of overweight/obesity status, higher level of aminotransferase (AST and ALT), homeostasis model assessment of insulin resistance (HOMA-IR), LAP, VAI, TyG, waist circumference (WC), and BMI (P < 0.05). Partial correlation analysis showed LAP, WC and BMI were significantly positively associated with CAP (P < 0.05) after controlling for confounding factors. Besides, BMI, WC, and CAP were gradually elevated with the increase of LAP level. Further, multivariable logistic regression analysis showed adjusted odd ratio (OR) with associated 95% CI (OR (95% CI)) were respectively 1.09 (1.03–1.16) for LAP, 1.14 (1.05–1.23) for WC, 1.28 (1.08–1.51) for BMI, respectively. Conclusions The present study demonstrates that in women with PCOS, except for the traditional adiposity indices (WC and BMI), LAP is independently correlated with the risk of HS.

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Section: Discussionmentioning

confidence: 99%

Lipid accumulation product independently correlate with hepatic steatosis quantified by controlled attenuation parameter in women with polycystic ovary syndrome

Zheng

Tong

Dong

et al. 2020

Endocrine Connections

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“…2,3 However, insulin resistance is significantly associated with liver fibrosis that predicts liver-related adversed outcomes (cirrhosis and mortality) in NAFLD. 4,5 Second, as shown in Table 1, the percentage of patients using pioglitazone was significantly greater in metformin users than nonusers. Pioglitazone improves insulin sensitivity by activating peroxisome proliferator-activated receptor-γ in the liver, muscle, and adipose tissues.…”

Section: Editorsmentioning

confidence: 89%

“…However, other mechanisms involving oncogenic signalling pathways, down-regulating pro-inflammatory cytokines, attenuating levels of reactive oxygen species and even modifying gut microbiota could also support its beneficial effects. 3,4 Dogru et al further suggested that other insulin sensitiser drugs such as pioglitazone might exert positive effects on study outcomes. Unfortunately, only 9% of patients were taking pioglitazone during the study period; therefore, sensitivity analyses exploring its relationship with transplant-free survival and HCC were not conducted.…”

Section: Editorsmentioning

confidence: 99%

Letter: metformin treatment and hepatocellular carcinoma risk in non‐alcoholic fatty liver disease

Doğru

Kırık

Sönmez³

2019

Aliment Pharmacol Ther

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“…In their study on genotype 1 HCV, Petta et al [16] found VAI score was independently associated with higher HOMA score, viral load, necro-inflammatory activity and steatosis. The same researchers claimed that VAI score was linked to severe fibrosis in non-alcoholic fatty liver disease (NAFLD) [41], Whereas others [42] found VAI is neither related to the severity of hepatic inflammation nor fibrosis in non-diabetic patients with NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Insulin Resistance, Visceral Adiposity Index and TyG Index in Genotype-4 Chronic HCV Patients and Their Relation to Hepatic Histopathology

Sabet¹,

Mohammad²,

Yousef³

et al. 2016

OJGas

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Introduction: Hepatitis C virus (HCV) genotype 4 is the most prevalent in Egypt. Visceral adiposity index (VAI) and (TyG) index are newly developed indices for assessment of metabolic syndrome (MS) and insulin resistance (IR). We aimed at comparing their levels in HCV-patients with healthy controls and validate their use for prediction of hepatic histopathological changes. Patient and Methods: 78 chronic HCV-infected patients proven by PCR, viral genotyping and hepatic histopathology, and 67 healthy controls were enrolled. Presence of MS, Homeostasis Model Assessment for IR estimation (HOMA-IR), TyG index, and VAI were assessed. Results: HOMA-IR, TyG and frequency of MS were significantly higher in patients' group (p < 0.0001 for each) in comparison to controls. In HCV patients, increased fasting blood glucose (FBG) was the only strong predictor of severe hepatic necro-inflammation. High FBG, older age, female sex, high AST, TyG, VAI, serum lipids abnormalities and presence of MS were all associated with severe fibrosis on univariate regression analysis. Only high AST, TyG, VAI and LDL were independent predictors of severe fibrosis. A model using the 4 parameters showed a strong validity in predicting advanced hepatic fibrosis (AUC 0.801; CI: 0.705-0.897, p < 0001). Female sex, high BMI, VAI, LDL and TG values are all significantly associated with moderate/severe steatosis on univariate analysis. Among them, high BMI and LDL are the strong predictors (AUC 0.738; CI 0.625-0.851, p = 0.002). Conclusion: HCV genotype 4 is significantly associated with MS and increased values of HOMA IR and TyG index. TyG index and VAI are valuable simple indices that could predict the histopathological changes in Egyptian CHC patients.

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Insulin Resistance but Not Visceral Adiposity Index Is Associated with Liver Fibrosis in Nondiabetic Subjects with Nonalcoholic Fatty Liver Disease

Abstract: Our findings suggest that VAI is not related to the severity of hepatic inflammation or fibrosis in nondiabetic patients with NAFLD. The lack of association between the adipocytokines and VAI also implies that the VAI may not be a significant indictor of the adipocyte functions.

Cited by 37 publications

References 36 publications

Lipid accumulation product independently correlate with hepatic steatosis quantified by controlled attenuation parameter in women with polycystic ovary syndrome

Lipid accumulation product independently correlate with hepatic steatosis quantified by controlled attenuation parameter in women with polycystic ovary syndrome

Letter: metformin treatment and hepatocellular carcinoma risk in non‐alcoholic fatty liver disease

Insulin Resistance, Visceral Adiposity Index and TyG Index in Genotype-4 Chronic HCV Patients and Their Relation to Hepatic Histopathology

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