Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration

Kamińśki, Mikołaj; Uruska, Aleksandra; Rogowicz-Frontczak, Anita; Lipski, Dawid; Niedźwiecki, Paweł; Różańska, Olga; Skonieczna, Paulina; Michalska, Anna; Flotyńska, Justyna; Araszkiewicz, Aleksandra; Uruski, Paweł; Pawlak, Regina; Zozulińska‐Ziółkiewicz, Dorota

doi:10.1055/a-0895-5166

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…VD deficiency and VD receptor polymorphisms were previously reported to be potential risk factors of developing T1DM [17,18]. Moreover, our observation revealed that VD serum concentration is negatively associated with insulin resistance in adults with T1DM [19]. In the same study, Kamiński et al reported that 47% of adults with T1DM had VD deficiency (25(OH)D) < 20 ng/mL) and 15% had VD severe deficiency (25(OH)D) < 10 ng/mL)in the period of limited insolation in Poland.…”

Section: Introductionsupporting

confidence: 60%

Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes

Kamińśki

Molenda

Banaś

et al. 2020

IJERPH

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Half of the individuals with type 1 diabetes (T1DM) may present Vitamin D (VD) deficiency. There is little known about factors determining a decision on VD supplementation. The study aimed to determine the factors affecting vitamin D supplementation in people with T1DM. A cross-sectional survey study using the authors’ questionnaire paper and its digital version was performed. The questions involved data on the basic characteristics of the respondent, medical history, VD supplementation status, influence of the social environment, self-education, and the most important personal motivator for VD supplement use. Multivariate logistic regression analysis was performed. We collected a total of n = 184 papers and n = 550 digital complete surveys. From 734 total respondents, 62.0% declared VD supplementation. The main personal rationale for VD supplementation were recommendation of medical specialist 172 (37.8%) and self-education 135 (29.7%). The main reasons for non-supplementation of VD were lack of knowledge about VD 159 (57.0%) and lack of motivation 77 (27.6%). VD supplementation was independently associated with a family doctor (odds ratio (OR), 95% confidence interval (CI): 4.67, 2.32–9.40) or medical specialist recommendation (16.20, 9.57–27.43), and self-education (5.97, 3.90–9.13). Most Polish individuals with T1DM use VD supplements, and the decision is related to physicians’ recommendations and self-education.

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Section: Introductionsupporting

confidence: 60%

Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes

Kamińśki

Molenda

Banaś

et al. 2020

IJERPH

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“…Functionally, sufficient serum 25(OH)D concentration can preserve the activity of residual pancreatic β-cells and insulin secretion [44]. Meanwhile, a past study reported that the serum 25 (OH)D concentration was negatively associated with insulin resistance in patients with T1DM [45]. Children with T1DM have also been reported to have lower 25(OH)D concentration than healthy children [5].…”

Section: Discussionmentioning

confidence: 99%

A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

et al. 2020

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It remains debatable whether vitamin D plays any role as a risk factor for type 1 diabetes mellitus (T1DM). We have summarized the effect of circulating 25-hydroxy vitamin D [25(OH)D] concentration on the risk of developing T1DM via a dose–response meta-analysis. We undertook a database search on PubMed, Embase, and Cochrane Library from inception to January 2020. A meta-analysis based on random-effects model was applied. Subgroup analysis and meta-regression were performed to inspect the source of heterogeneity. Dose–response data were examined using the generalized least squares trend estimation method. This study was registered with the PROSPERO (ID: CRD42020166174). In total, 16 studies including 10,605 participants (3913 case patients) were included. The pooled odds ratios (OR) and 95% confidence intervals (95% CI) for the highest versus the lowest 25(OH)D concentration was 0.39 (0.27, 0.57), with a high heterogeneity (I2 = 76.7%, P < 0.001). Meta-regression analysis identified latitude (P = 0.02), adjustment for gender (P = 0.001), and 25(OH)D stratification (P < 0.001) as sources of heterogeneity. Furthermore, the nonlinear dose–response analysis determined the OR (95% CI) of T1DM to be 0.91 (0.90, 0.93) per 10 nmol/L increase in the 25(OH)D concentration. A ‘U’-shaped association was found between serum 25(OH)D concentration and risk of T1DM. The present study highlights the significant inverse association between the circulating 25(OH)D concentration and the risk of T1DM.

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“…There is much less data available regarding adult patients with T1D. It has been observed that the serum concentration of VD is negatively associated with IR in adult diabetic patients recruited in Poland [37]. In Algerian population, the link between VD deficiency and an increased risk of T1D was also found [38].…”

Section: Vitamin D Deficiency and Type 1 Diabetes Mellitusmentioning

confidence: 99%

Vitamin D Deficiency and Diabetes Mellitus

Shymanskyi¹,

Lisakovska²,

Mazanova³

et al. 2020

Vitamin D Deficiency

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Vitamin D (VD) is a molecule that can be synthesized directly in the humans' body or enter the organism with food in the form of inactive precursors. To exert its biological action, VD undergoes two-stage hydroxylation (at the 25th and 1st position) catalyzed by cytochromes P450, the presence of which has already been shown in almost all tissues of the human body. The product of hydroxylation is hormone-active form of vitamin D-1,25(OH) 2 D. 1,25(OH) 2 D binds to specific vitamin D receptor (VDR) and regulates the expression of genes involved in bone remodeling (classical function) and genes that control immune response, hormone secretion, cell proliferation, and differentiation (nonclassical functions). VD deficiency is prevalent around the globe and may be one of the key factors for diabetes development. The direct association between vitamin D deficiency and type 1 (T1D) and type 2 (T2D) diabetes has been proven. Detection of VDR in pancreas and adipose tissue, skeletal muscles, and immune cells allowed implying the antidiabetic role of vitamin D by enhancing insulin synthesis and exocytosis, increasing the expression of the insulin receptor, and modulating immune cells' functions. This chapter summarizes data about relationship between VD insufficiency/deficiency and development of T1D and T2D, and their complications.

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Insulin Resistance in Adults with Type 1 Diabetes is Associated with Lower Vitamin D Serum Concentration

Cited by 7 publications

References 42 publications

Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes

Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes

A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

Vitamin D Deficiency and Diabetes Mellitus

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