Insulin resistance in Alzheimer’s disease: The genetics and metabolomics links

Amin, Arwa M.; Mostafa, Hamza; Khojah, Hani M J

doi:10.1016/j.cca.2022.12.016

Cited by 8 publications

(2 citation statements)

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“…It provides an overview of the metabolic status and global biochemical events associated with a cellular or biological system, focusing on the study of hundreds of metabolites in cells, tissues, and biofluids [8]. Spectroscopic analysis of different biosamples has been employed in metabolomics studies to collect metabolites based on specific phenotypes such as illness, condition, or exposure to treatment [9]. In the context of food and nutrition, nutrimetabolomics (or nutritional or food metabolomics) is a new concept related to nutritional science, and it is crucial to decode the link between diet and health [10].…”

Section: Introduction To Metabolomicsmentioning

confidence: 99%

A Narrative Review of Metabolomic Insights into Olive Oil’s Nutritional Value

Gonçalves,

Rodríguez-Pérez,

Calabrò

et al. 2024

Applied Sciences

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This review explores the critical role of advanced metabolomic methodologies in interpreting the complex relationship between the bioactive compounds in olive oil and their health benefits. Olive oil, the cornerstone of the Mediterranean diet, is renowned for its numerous health benefits, including anti-inflammatory, antioxidant, and cardioprotective properties. This review begins with an overview of the importance of olive oil for nutrition and health, followed by a detailed discussion of the key metabolites that contribute to its therapeutic potential. It further explores the evolution of analytical techniques in metabolomics from traditional methods to cutting-edge technologies, such as mass spectrometry and nuclear magnetic resonance spectroscopy, which have enhanced our understanding of the complex composition of olive oil. This review highlights how these advanced analytical findings correlate with the known health properties of olive oil and presents case studies in which these methodologies have led to new insights. Finally, we address the challenges in standardizing these techniques and discuss future research directions, underscoring the significance of metabolomics in nutritional science and public health. This comprehensive analysis aims to provide a deeper understanding of the health benefits of olive oil, informed by the latest advancements in analytical methodologies.

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Section: Introduction To Metabolomicsmentioning

confidence: 99%

A Narrative Review of Metabolomic Insights into Olive Oil’s Nutritional Value

Gonçalves,

Rodríguez-Pérez,

Calabrò

et al. 2024

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…Systems biology is an approach to understanding complexity at many levels—by integrating contributing and interacting data. Others advocate for mathematical or engineering perspectives, or “downstream” omics approaches, including genomics, transcriptomics, metabolomics, lipidomics, and proteomics (Amin et al, 2022), particularly useful for explanatory models of disorders and diseases. Typically, there are two approaches—a top down and a bottom-up—in systems biology (Hussain et al, 2022).…”

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confidence: 99%