Insulin resistance in Nigerians with essential hypertension

Akande, T. O.; Jo, Ara; Kadiri, S. Abdelkarim

doi:10.4314/ahs.v13i3.19

Cited by 21 publications

(16 citation statements)

References 23 publications

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“…The first is that body composition estimated by bioelectrical impedance showed a high frequency of visceral fat accumulation in hypertensive vs normotensive patients in a South-Kivu population. Moreover, although Saad MF et al reported that the association between blood pressure and insulin resistance was limited to Caucasians and absent among blacks and PIMA Indians [ 12 ], the present observation suggests a role for excess visceral fat (and insulin resistance) in the pathogenesis of arterial hypertension in black subjects corroborating other authors [ 25 ]. We noted, however, that another study reported a lack of correlation between blood pressure and insulin resistance in diabetic patients [ 26 ].…”

Section: Discussionsupporting

confidence: 90%

Bioelectrical impedance outperforms waist circumference for predicting cardiometabolic risk in Congolese hypertensive subjects: a cross-sectional study

Katchunga

Bapolisi

M'Buyamba-Kabangu

et al. 2015

BMC Cardiovasc Disord

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BackgroundWaist circumference threshold values used in sub-Saharan Africa correspond to those of European populations and are therefore inappropriate. Thus, they may over predict insulin resistance, especially in hypertensive Africans, in whom there is often no association between blood pressure and insulin resistance. Using bioelectrical impedance measurement in sub-Saharan Africa could possibly be advantageous to overcome the shortcomings of waist circumference measurement. The aim of this study was to evaluate the contribution of body composition estimation by bioelectrical impedance to predict cardiometabolic risk in Congolese hypertensive subjects.MethodsCardiovascular profiling and body composition analysis by bioelectrical impedance was measured in 400 patients (men = 40%; age = 51.1 ± 12.6 years). Patients were diagnosed with a metabolic syndrome (MS) according to the IDF Criteria with and without the “blood pressure” criterion to remove any confounding autocorrelation bias, a visceral fat-MS (with and without the “blood pressure” criterion) being defined by the presence of ≥ 2 criteria with the precondition of excess visceral fat defined by a bio impedance measurement score >10/30. Total cardiovascular risk was assessed using the criteria of Framingham-2008.ResultsThe frequencies of enlarged waist circumference (71.9% vs 68.9%, p = 0.52) and IDF-MS without blood pressure criterion (24.9% vs 21.9%, p = 0.48) were similar among hypertensive vs. non hypertensive however excess visceral fat (57.6% vs 33.8%, p <0.0001) as well as visceral fat-MS without blood pressure criterion (18.9% vs 11.3%, p = 0.04) were more prevalent among hypertensive. Finally, total cardiovascular risk as well as arterial hypertension risk were associated with visceral fat, but not with waist circumference (p > 0.05).ConclusionsPending the determination of thresholds values for pathological waist circumference adapted to sub-Saharan populations, using bioelectrical impedance measurement may contribute to better characterize the cardiometabolic risk and the insulin resistant phenotype of hypertensive sub-Saharan Africans.

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Section: Discussionsupporting

confidence: 90%

Bioelectrical impedance outperforms waist circumference for predicting cardiometabolic risk in Congolese hypertensive subjects: a cross-sectional study

Katchunga

Bapolisi

M'Buyamba-Kabangu

et al. 2015

BMC Cardiovasc Disord

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“…Previous studies demonstrated associations between hypertension [ 43 ], obesity [ 32 ], inflammation [ 44 ], lifestyle [ 45 ], and liver disease [ 46 ] and QTc prolongation. TyG index is reported to be a simple surrogate of insulin resistance [ 47 ], and numerous studies also found a relationship between insulin resistance and hypertension [ 48 , 49 ]. In an animal study, Lin et al [ 50 ] found that insulin resistant, obese, 16 to 17-week-old rats exhibited defective inactivation of current, altered electrophysiology characteristics, and developed cardiac hypertrophy due to a prolongation of QTc interval.…”

Section: Discussionmentioning

confidence: 99%

Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Lee

Hsuan

et al. 2021

IJERPH

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Objectives: Increased triglyceride glucose (TyG) index appears to be linked to carotid and coronary atherosclerosis and calcifications and possesses an elevated future risk of developing cardiovascular disease. Corrected QT (QTc) interval prolongation is associated with ventricular arrhythmias and sudden cardiac death, and a high prevalence of prolonged QTc interval was previously reported in blue-collar workers. The purpose of this study was to find the possible causal inter-relationship between TyG index and QTc interval in a large population of Chinese male steelworkers. Methods: A total of 3189 male workers from two steel plants were enrolled. They responded to a cross-sectional questionnaire on basic attributes and lifestyle, including sleep patterns. All workers in the two plants underwent periodic health checkups, including twelve-lead electrocardiography. Structural equation modeling (SEM) was used to assess the direct and indirect effects of TyG index on QTc interval. Results: With increasing TyG index tertile, the male steelworkers had an increased QTc interval. Applying multivariate analysis, TyG index was associated independently with the odds of QTc prolongation (adjusted odds ratio = 2.73, 95% confidence interval = 1.39–5.24, p = 0.004). SEM revealed that TyG index, hypertension, obesity, lifestyle, white blood cell (WBC) count, and liver function had statistically significant direct effects on QTc interval. Furthermore, TyG index also had an indirect effect on QTc interval through hypertension, obesity, WBC count, and liver function. Moreover, lifestyle had an indirect effect on QTc interval through TyG index. The final model explained 14% of the variability in QTc interval. Conclusions: An increased TyG index was associated with QTc interval prolongation in this study, and SEM delineated possible causal pathways and inter-relationships of the risk factors contributing to the occurrence of QTc prolongation among Chinese male steelworkers.

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“…We found that hypertension combined with HTG can signi cantly increase the risk of developing hyperuricemia than any separate hypertension or HTG. Insulin resistance is partially overlapping pathophysiological features of dyslipidemia and hypertension [18][19][20][21]. Much researches have con rmed that insulin resistance was correlated with hyperuricemia [22,23].…”

Section: Discussionmentioning

confidence: 99%

Association of Hypertension and Hypertriglyceridemia on Incident Hyperuricemia: An 8-year Prospective Cohort Study

Zhang

et al. 2020

Preprint

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BackgroundHypertension and high triglyceride are two of the most important risk factors for hyperuricemia. Epidemiological records show that hypertension and dyslipidemia often coexist and may significantly increase the risk of target organ damage. However, their combined effect on incident hyperuricemia is poorly understood. Thus, we aimed to investigate the separate and combined effect of hypertension and hypertriglyceridemia on the incidence of hyperuricemia.MethodsA prospective cohort study of 6424 hyperuricemia-free participants aged 20 to 94 years between August 2009 and October 2017 was performed at Tianjin General Hospital of China. Participants were categorized into four groups by combining hypertension and hypertriglyceridemia status at baseline. The restricted cubic spline fitting Cox regression model was used to evaluate the relationship between blood pressure and triglyceride and hyperuricemia. Cox regression models were performed to calculate hazard ratios (HRs) and 95% confident intervals (CIs) to estimate baseline factors and their association with the incidence of hyperuricemia. A Kaplan–Meier survival analysis was performed to compare the incidence of hyperuricemia among subjects in each separate and combined hypertension and hypertriglyceridemia group.ResultsDuring the 8-year follow-up period, 1,259 subjects developed hyperuricemia (20.6%). There existed positive relationships between blood pressure and triglyceride levels and hyperuricemia. This risk factor arising from a combination of the two (HR, 3.02; 95% CI: 2.60-3.50) is greater than that from hypertension (HR, 1.48; 95% CI: 1.28-1.71) or hypertriglyceridemia (HR, 1.84; 95% CI: 1.55-2.18) separately. The Kaplan–Meier survival analysis indicated that combined effect of hypertension and hypertriglyceridemia may predict higher onset of hyperuricemia.ConclusionThe combined effect of hypertension and hypertriglyceridemia on the risk of hyperuricemia is much stronger than that by hypertension or hypertriglyceridemia separately. Hypertension combined with hypertriglyceridemia may be an independent and powerful predictor for hyperuricemia.

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Insulin resistance in Nigerians with essential hypertension

Cited by 21 publications

References 23 publications

Bioelectrical impedance outperforms waist circumference for predicting cardiometabolic risk in Congolese hypertensive subjects: a cross-sectional study

Bioelectrical impedance outperforms waist circumference for predicting cardiometabolic risk in Congolese hypertensive subjects: a cross-sectional study

Association between Triglyceride Glucose Index and Corrected QT Prolongation in Chinese Male Steelworkers

Association of Hypertension and Hypertriglyceridemia on Incident Hyperuricemia: An 8-year Prospective Cohort Study

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